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Autor:
Xiaofei Zheng, Shiwen Zhang, Guomin Ou, Peng Deng, Yunshu Wu, Cun-Yu Wang, Qiwen Li, Yuchen Guo, Y. Chen, Quan Yuan, Yuting Liu, Xingying Qi, Weiqing Liu, Yuan Wang, Liyan Zhou, Weimin Lin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in th
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Repair of broken DNA by homologous recombination requires coordinated enzymatic reactions to prepare it for interaction with intact DNA. The multiple activities of enterobacterial RecBCD helicase-nuclease are coordinated by Chi recombination hotspots
Autor:
Joo-ri Kim-Kaneyama, Shogo Haraguchi, Xiao-Feng Lei, Tomokatsu Omoto, Lin Gao, Akira Miyazaki, Masahito Noguchi, Aya Miyauchi, Takuro Miyazaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Accumulated evidence suggests that activated pancreatic stellate cells (PSCs) serve as the main source of the extracellular matrix proteins accumulated under the pathological conditions leading to pancreatic fibrosis in chronic pancreatitis (CP). How
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
Platelet Derived Growth Factor Receptor (PDGFR) signaling is a central mitogenic pathway in development, as well as tissue repair and homeostasis. The rules governing the binding of PDGF ligand to the receptor to produce activation and downstream sig
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
In the complex interplay of beneficial bacteria with the host, there are few examples of bacterial metabolites and effector molecules that have been consistently identified. Protective effects on the intestinal epithelium have been ascribed to P40 an
Autor:
Marcus B. Smolka, William J. Comstock, Shannon Marshall, Vitor M. Faça, Shagun Gupta, Jennifer H. Tieu, Ethan J. Sanford, Haiyuan Yu
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The maintenance of genomic stability relies on DNA damage sensor kinases that detect DNA lesions and phosphorylate an extensive network of substrates. The Mec1/ATR kinase is one of the primary sensor kinases responsible for orchestrating DNA damage r
Autor:
Mary Ziegler, Katrina M. Welch-Reardon, Nathan N. Shon, Jennifer S. Fang, Nan W. Hultgren, Duc T. T. Phan, Antonio E. Paniagua, Ali Mortazavi, Ricardo Ramirez, Christopher C.W. Hughes, Lin S. Kim, Michaela M.S. Hatch, David S. Williams
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Slug (SNAI2), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal transition (EMT). Here, we show that Slug is critical for the pathological angiogenesis neede
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Pepper (Capsicum annuum L.) fruit is sensitive to temperatures below 10 °C, which severely diminish fruit quality during cold chain distribution. Seed browning was a major chilling symptom in 36 genotypes of C. annuum fruit screened after storage at
Autor:
Guy M. Benian, Courtney J. Christian, Eric A. Ortlund, Jasmine C. Moody, C. Denise Okafor, Niveda Shanmugan, April R. Reedy, Hiroshi Qadota, Yohei Matsunaga
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
PIX proteins are guanine nucleotide exchange factors (GEFs) that activate Rac and Cdc42, and are known to have numerous functions in various cell types. Here, we show that a PIX protein has an important function in muscle. From a genetic screen in C.
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications
Nature Communications
Harmful effects of high fructose intake on health have been widely reported. Although fructose is known to promote cancer, little is known about the underlying mechanisms. Here, we found that fructose triggers breast cancer metastasis through the ket