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pro vyhledávání: ''
Autor:
Costantino Pitzalis, Esteban A. Gomez, Conrad Bessant, Romain A. Colas, Rebecca Hands, Myles Lewis, Patricia R. Souza, Jesmond Dalli
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral
Autor:
David H. Ebb, Cassandra Garbutt, Christopher E. Lietz, Brian Lawney, Vikram Deshpande, Zhenfeng Duan, Yen-Lin Chen, Francis J. Hornicek, Dimitrios Spentzos, Santiago A. Lozano-Calderon, G. Petur Nielsen, Benjamin Haibe-Kains, Gregory M. Cote, John Quackenbush, William T. Barry, Yaoyu E. Wang, Edwin Choy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports
BackgroundThere is a lack of well validated biomarkers in osteosarcoma, a rare, recalcitrant disease with variable outcome and poorly understood biologic behavior, for which treatment standards have stalled for decades. The only standard prognostic f
Autor:
Hanqi Tang, Wen Zhang, Panpan Zhang, Jiuliang Zhao, Hua Chen, Yunyun Fei, Di Wu, Xuan Zhang, Shangzhu Zhang, Huaxia Yang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Linyi Peng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports
Scientific Reports
This prospective cohort study aims to investigate the incidence, related factors and prognosis of IgG4-related disease (IgG4-RD) with malignancies in the Chinese cohort. We prospectively analyzed the IgG4-RD patients recruited in Peking Union Medical
Autor:
Àngel Argilés, Vasiliki Lygirou, Eleni Petra, Flore Duranton, Harald Mischak, Manousos Makridakis, Jerome Zoidakis, Szymon Filip, Antonia Vlahou, Georgia Kontostathi, Rafael Stroggilos
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Current diagnostic measures for Chronic Kidney Disease (CKD) include detection of reduced estimated glomerular filtration rate (eGFR) and albuminuria, which have suboptimal accuracies in predicting disease progression. The disease complexity and hete
Autor:
Mustafa Ascha, Jill S. Barnholtz-Sloan, Andrew E Sloan, Jacqueline Wang, Carol Kruchko, Priya Kumthekar
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
Bevacizumab is FDA-approved in the treatment of primary brain tumors, but its efficacy in patients with brain metastases could be better-studied. This study examines a population of non-small cell lung cancer (NSCLC) patients with synchronous brain m
Autor:
Laguzzi, Federica, Maitusong, Buamina, Strawbridge, Rona J., Baldassarre, Damiano, Veglia, Fabrizio, Humphries, Steve E., Rauramaa, Rainer, Kurl, Sudhir, Smit, Andries J., Giral, Philippe, Silveira, Angela, Tremoli, Elena, Hamsten, Anders, de Faire, Ulf, Gigante, Bruna, Leander, Karin, Sirtori, C. R., Calabresi, L., Amato, M., Frigerio, B., Ravani, A., Sansaro, D., Tedesco, C., Coggi, D., Capra, N., Bonomi, A., Eriksson, P., Cooper, J., Acharya, J., Savonen, K., Huttunen, K., Rauramaa, E., Penttila, I. M., Törrönen, J., van Gessel, A. I., van Roon, A. M., Nicolai, A., Mulder, D. J., Kontush, A., Carrié, A., Gallo, A., Karppi, J., Nurmi, T., Nyyssönen, K., Tuomainen, T. P., Tuomainen, J., Kauhanen, J., Sennblad, B., Pirro, M., Vaudo, G., Siepi, D., Lupattelli, G., Mannarino, M. R., Bianconi, V.
Publikováno v:
Scientific Reports, 11(1):7866. Nature Publishing Group
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.7866. ⟨10.1038/s41598-021-86324-w⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports, Nature Publishing Group, 2021, 11 (1), pp.7866. ⟨10.1038/s41598-021-86324-w⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it woul
Autor:
Luisa F. Escobar-Hoyos, Lucia Roa-Peña, Kenneth R. Shroyer, Chun-Hao Pan, Jela Bandovic, Richard A. Moffitt, Cindy V. Leiton, Elizabeth A. Vanner, Ali Akalin, Sruthi Babu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Although the overall five-year survival of patients with pancreatic ductal adenocarcinoma (PDAC) is dismal, there are survival differences between cases with clinically and pathologically indistinguishable characteristics, suggesting that there are u
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The risk of osteoporosis in patients with chronic inflammatory neuropathy (CIN) has not been evaluated in detail. We conducted a population-based case-control study nested in a retrospective cohort to analyze osteoporosis risk among patients with CIN
Autor:
Paul Saftig, Peter Kunach, Randall J. Bateman, Wiesje M. van der Flier, Philip Scheltens, Judes Poirier, John C.S. Breitner, Pedro Rosa-Neto, Mark A. Hancock, Christoph Hock, Vivienne Engelschalt, Filip Liebsch, Adeola Shobo, Charlotte E. Teunissen, Irem Ulku, Gerhard Multhaup, Luka Kulic
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, 10(1):2240. Nature Publishing Group
Nature Communications
Liebsch, F, Kulic, L, Teunissen, C, Shobo, A, Ulku, I, Engelschalt, V, Hancock, M A, van der Flier, W M, Kunach, P, Rosa-Neto, P, Scheltens, P, Poirier, J, Saftig, P, Bateman, R J, Breitner, J, Hock, C & Multhaup, G 2019, ' Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression ', Nature Communications, vol. 10, no. 1, 2240 . https://doi.org/10.1038/s41467-019-10152-w
Nature Communications, 10(1):2240. Nature Publishing Group
Nature Communications
Liebsch, F, Kulic, L, Teunissen, C, Shobo, A, Ulku, I, Engelschalt, V, Hancock, M A, van der Flier, W M, Kunach, P, Rosa-Neto, P, Scheltens, P, Poirier, J, Saftig, P, Bateman, R J, Breitner, J, Hock, C & Multhaup, G 2019, ' Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression ', Nature Communications, vol. 10, no. 1, 2240 . https://doi.org/10.1038/s41467-019-10152-w
The beta-site APP cleaving enzyme 1 (BACE1) is known primarily for its initial cleavage of the amyloid precursor protein (APP), which ultimately leads to the generation of Aβ peptides. Here, we provide evidence that altered BACE1 levels and activity
A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome
Autor:
Soret, Perrine, Le Dantec, Christelle, Desvaux, Emiko, Foulquier, Nathan, Chassagnol, Bastien, Hubert, Sandra, Jamin, Christophe, Barturen, Guillermo, Desachy, Guillaume, Devauchelle-Pensec, Valérie, Boudjeniba, Cheïma, Cornec, Divi, Saraux, Alain, Jousse-Joulin, Sandrine, Barbarroja, Nuria, Rodríguez-Pintó, Ignasi, De Langhe, Ellen, Beretta, Lorenzo, Chizzolini, Carlo, Kovács, László, Witte, Torsten, Bettacchioli, Eléonore, Buttgereit, Anne, Makowska, Zuzanna, Lesche, Ralf, Borghi, Maria Orietta, Martin, Javier, Courtade-Gaiani, Sophie, Xuereb, Laura, Guedj, Mickaël, Moingeon, Philippe, Alarcón-Riquelme, Marta, Laigle, Laurence, Pers, Jacques-Olivier, Vigone, Barbara, Lauwerys, Bernard, Maudoux, Anne-Lise, Vasconcelos, Carlos, Tavares, Ana, Faria, Raquel, Brandão, Mariana, Campar, Ana, Marinho, António, Farinha, Fátima, Almeida, Isabel, Gonzalez-Gay Mantecón, Miguel Angel, Blanco Alonso, Ricardo, Corrales Martínez, Alfonso, Cervera, Ricard, Espinosa, Gerard, Lories, Rik, Hunzelmann, Nicolas, Belz, Doreen, Baerlecken, Niklas, Stummvoll, Georg, Zauner, Michael, Lehner, Michaela, Collantes, Eduardo, Ortega-Castro, Rafaela, Aguirre-Zamorano, Ma Angeles, Escudero-Contreras, Alejandro, Castro-Villegas, Ma Carmen, Jiménez Gómez, Yolanda, Ortego, Norberto, Fernández Roldán, María Concepción, Raya, Enrique, Jiménez Moleón, Inmaculada, de Ramon, Enrique, Díaz Quintero, Isabel, Meroni, Pier Luigi, Gerosa, Maria, Schioppo, Tommaso, Artusi, Carolina, Zuber, Aleksandra, Wynar, Donatienne, Balog, Attila, Deák, Magdolna, Bocskai, Márta, Dulic, Sonja, Kádár, Gabriella, Hiepe, Falk, Thiel, Silvia, Rodriguez Maresca, Manuel, López-Berrio, Antonio, Aguilar-Quesada, Rocío, Navarro-Linares, Héctor, Ioannou, Yiannis, Chamberlain, Chris, Marovac, Jacqueline, Alarcón Riquelme, Marta, Gomes Anjos, Tania, Marañón, Concepción, Le Lann, Lucas, Simon, Quentin, Rouvière, Bénédicte, Varela, Nieves, Muchmore, Brian, Dufour, Aleksandra, Alvarez, Montserrat, Cremer, Jonathan, Lopez-Pedrera, Chary, Gerl, Velia, Khodadadi, Laleh, Cheng, Qingyu, De Groof, Aurélie, Ducreux, Julie, Trombetta, Elena, Li, Tianlu, Alvarez-Errico, Damiana, Kniesch, Katja, Azevedo, Nancy, Neves, Esmeralda, Rao, Sambasiva, Jouve, Pierre-Emmanuel
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.3523. ⟨10.1038/s41467-021-23472-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
There is currently no approved treatment for primary Sjögren’s syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5182e71983a3c820bc2eed151f2178
http://hdl.handle.net/10261/250682
http://hdl.handle.net/10261/250682