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Autor:
Fernando J. Monteiro, Paulo Costa, Laura Costa, Tatiana Padrão, Susana Sousa, Catarina C. Coelho, Paulo A. Quadros, Valentina F. Domingues, Marta Pinto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Scientific Reports
Bone graft infections are serious complications in orthopaedics and the growing resistance to antibiotics is increasing the need for antibacterial strategies. The use of magnesium oxide (MgO) is an interesting alternative since it possesses broad-spe
Autor:
John R. Mackey, Muba Taher, Parsin Haji Reza, Frank van Landeghem, Saad Abbasi, Deepak Dinakaran, Kevan Bell, Gilbert Bigras
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Histological visualizations are critical to clinical disease management and are fundamental to biological understanding. However, current approaches that rely on bright-field microscopy require extensive tissue preparation prior to imaging. These pro
Autor:
Robert R. Thomson, Jonathan D. Shephard, Rainer J. Beck, David Jayne, Nicholas P. West, Mike Shires, Duncan Paul Hand, Ioannis Bitharas, T Maisey, Andrew J. Moore
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Endoluminal surgery for the treatment of colorectal neoplasia is typically carried out using electrocautery tools which imply limited precision and the risk of harm through collateral thermal damage to the adjacent healthy tissue. As a potential alte
Autor:
Yu Kimura, Teruyuki Kondo, Natsuki Matsumoto, Hisatsugu Yamada, Aoi Son, Hiroaki Konishi, Tetsuya Matsuda, Hirohiko Imai, Yasuhiro Aoyama, Takanori Komaki
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Three-dimensional (3D) representation of a tumor with respect to its size, shape, location, and boundaries is still a challenge in photoacoustic (PA) imaging using artificial contrast agents as probes. We carried out PA imaging of tumors in mice usin
Autor:
Jun Yong Lee, David J. Mooney, Bo Ri Seo, David M. Wu, Catia S. Verbeke, Miguel C. Sobral, Hua Wang, Aileen Weiwei Li, Alexander J. Najibi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Poorly immunogenic tumors, including triple negative breast cancers (TNBCs), remain resistant to current immunotherapies, due in part to the difficulty of reprogramming the highly immunosuppressive tumor microenvironment (TME). Here we show that peri
Autor:
D. Jaison, S. Shantanu Patil, B. K. Mohamed Ibrahim, V Gopinath, S. Padmapriya, Nilkantha Gupta, S. Manjunath Kamath, K. Sridhar, P. Sivaperumal, A. Sundaram
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Modulation of initial burst and long term release from electrospun fibrous mats can be achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous polycaprolactone (PCL). Ibuprofen (IBU) loaded PCL fibrous mats (12% PCL-IBU) we
Autor:
Xiaowei Hong, Andrew J. Putnam, Nicole E. Friend, Ana Y. Rioja, Jan P. Stegemann, Cheri X. Deng, Yen Peng Kong, Julia C. Habif, Jeffrey A. Beamish, Jonathan R. Bezenah
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports
Scientific Reports
Revascularization of ischemic tissues is a major barrier to restoring tissue function in many pathologies. Delivery of pro-angiogenic factors has shown some benefit, but it is difficult to recapitulate the complex set of factors required to form stab
Autor:
Yamei Tang, Xinyi Chen, Leo Y. C. Yan, Ho Yin Edwin Chan, Hon-Cheong So, Lei Zhao, Wei-Jye Lin, Hei-Ming Lai, Zhongqi Li, Yu Huang, Xiao Yu Tian, Wai-Lung Ng, Samuel K. H. Sy, Joaquim S. L. Vong, Ho Ko, Junzhe Huang, Vincent Mok
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The molecular signatures of cells in the brain have been revealed in unprecedented detail, yet the ageing-associated genome-wide expression changes that may contribute to neurovascular dysfunction in neurodegenerative diseases remain elusive. Here, w
Autor:
Minomi Subapanditha, Chitra Venugopal, Neil Winegarden, Ashley A. Adile, Robin M. Hallett, Blake Yarascavitch, John Provias, David Bakhshinyan, Blessing Bassey-Archibong, Neil Savage, Bradley W. Doble, Laura M. Richards, Dillon McKenna, Trevor J. Pugh, Olufemi Ajani, Owen Whitley, Nazanin Tatari, Michelle Kameda-Smith, Adam Fleming, Anna Dvorkin-Gheva, Branavan Manoranjan, Sheila K. Singh, Gary D. Bader
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Medulloblastoma (MB) is defined by four molecular subgroups (Wnt, Shh, Group 3, Group 4) with Wnt MB having the most favorable prognosis. Since prior reports have illustrated the antitumorigenic role of Wnt activation in Shh MB, we aimed to assess th
Autor:
Jimena Perez-Sanchez, Antoine G. Godin, Adalberto Merighi, Louis-Etienne Lorenzo, Yves De Koninck, Nicolas Doyon, Annie Castonguay, Samuel Ferland, Martin Cottet, Francesco Ferrini, Feng Wang, Isabel Plasencia-Fernandez, Chiara Salio
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications
Nature Communications
GABAA/glycine-mediated neuronal inhibition critically depends on intracellular chloride (Cl−) concentration which is mainly regulated by the K+-Cl− co-transporter 2 (KCC2) in the adult central nervous system (CNS). KCC2 heterogeneity thus affects