Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lukas Reiter"'
Autor:
Lidia Wrobel, Sandra M. Hill, Alvin Djajadikerta, Marian Fernandez-Estevez, Cansu Karabiyik, Avraham Ashkenazi, Victoria J. Barratt, Eleanna Stamatakou, Anders Gunnarsson, Timothy Rasmusson, Eric W. Miele, Nigel Beaton, Roland Bruderer, Yuehan Feng, Lukas Reiter, M. Paola Castaldi, Rebecca Jarvis, Keith Tan, Roland W. Bürli, David C. Rubinsztein
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Several neurodegenerative diseases are characterized by the aggregation of cytoplasmic proteins. Here, the authors demonstrate that the small molecule SMER28 activates VCP, which enhances both autophagic and proteasomal clearance of aggregate-prone p
Externí odkaz:
https://doaj.org/article/02631720e7494834abf742bdf764ec8e
Autor:
Ying Jin, Xiaoyu An, Binchen Mao, Ruilin Sun, Rajendra Kumari, Xiaobo Chen, Yongli Shan, Mingfa Zang, Ling Xu, Jan Muntel, Kristina Beeler, Roland Bruderer, Lukas Reiter, Sheng Guo, Demin Zhou, Qi-Xiang Li, Xuesong Ouyang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Cancers are immunologically heterogeneous. A range of immunotherapies target abnormal tumor immunity via different mechanisms of actions (MOAs), particularly various tumor-infiltrate leukocytes (TILs). We modeled loss of function (LOF) in fo
Externí odkaz:
https://doaj.org/article/f458fcf37994447d8b6641e56cd067f3
Autor:
Ilaria Piazza, Nigel Beaton, Roland Bruderer, Thomas Knobloch, Crystel Barbisan, Lucie Chandat, Alexander Sudau, Isabella Siepe, Oliver Rinner, Natalie de Souza, Paola Picotti, Lukas Reiter
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Proteomics is often used to map protein-drug interactions but identifying a drug’s protein targets along with the binding interfaces has not been achieved yet. Here, the authors integrate limited proteolysis and machine learning for the proteome-wi
Externí odkaz:
https://doaj.org/article/871b54abd526490392ac0a0d980afcf1
Autor:
Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Alexander Hogrebe, Ana Martinez-Val, Lynn Verbeke, Tejas Gandhi, Christian D. Kelstrup, Lukas Reiter, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Localizing phosphorylation sites by data-independent acquisition (DIA)-based proteomics is still challenging. Here, the authors develop algorithms for phosphosite localization and stoichiometry determination, and incorporate them into single-shot DIA
Externí odkaz:
https://doaj.org/article/448cb8a30d124c708cc21f898c76c600
Autor:
Marc van Oostrum, Maik Müller, Fabian Klein, Roland Bruderer, Hui Zhang, Patrick G. A. Pedrioli, Lukas Reiter, Panagiotis Tsapogas, Antonius Rolink, Bernd Wollscheid
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Analysis of the cell surface proteome (surfaceome) is essential for cell classification but is technically challenging. Here the authors miniaturize and automate the Cell Surface Capture method to increase sensitivity, reproducibility and throughput,
Externí odkaz:
https://doaj.org/article/01b86678a26449fb9e9fa7dde5e4ac4a