Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Guangxun Meng"'
Autor:
Danfeng Dong, Yuzhang Du, Xuefeng Fei, Hao Yang, Xiaofang Li, Xiaobao Yang, Junrui Ma, Shu Huang, Zhihui Ma, Juanjuan Zheng, David W. Chan, Liyun Shi, Yunqi Li, Aaron T. Irving, Xiangliang Yuan, Xiangfan Liu, Peihua Ni, Yiqun Hu, Guangxun Meng, Yibing Peng, Anthony Sadler, Dakang Xu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Inflammasome activity is important for the immune response and is instrumental in numerous clinical conditions. Here we identify a mechanism that modulates the central Caspase-1 and NLR (Nod-like receptor) adaptor protein ASC (apoptosis-asso
Externí odkaz:
https://doaj.org/article/7f19608cb89141d283f2dcd9b36f3fb4
Autor:
Junling Niu, Mengmeng Cui, Xin Yang, Juan Li, Yuhui Yao, Qiuhong Guo, Ailing Lu, Xiaopeng Qi, Dongming Zhou, Chenhong Zhang, Liping Zhao, Guangxun Meng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The NLRP3 inflammasome plays a pivotal role in clearing viral respiratory infection, but the molecular mechanism is not fully known. Here authors show that acetate, produced by gut bacteria, may enhance NLRP3-mediated type I interferon production fol
Externí odkaz:
https://doaj.org/article/aadf1ef849a44449b71611edcfea5787
Autor:
Peipei Zhou, Xiaodan Ding, Xiaoling Wan, Lulu Liu, Xiujie Yuan, Wei Zhang, Xinhui Hui, Guangxun Meng, Hui Xiao, Bin Li, Jin Zhong, Fajian Hou, Lihwen Deng, Yan Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
MLL5 is an essential epigenetic modifier involved in cell cycle progression, chromatin architecture and hematopoiesis. Here the authors establish that MLL5 suppresses the innate immune response in a murine model of virus infection by targeting and pr
Externí odkaz:
https://doaj.org/article/e70d4a2c123b46d1aff993ffe9991d7e
Autor:
Xiaomin Yao, Chenhong Zhang, Yue Xing, Guang Xue, Qianpeng Zhang, Fengwei Pan, Guojun Wu, Yingxin Hu, Qiuhong Guo, Ailing Lu, Xiaoming Zhang, Rongbin Zhou, Zhigang Tian, Benhua Zeng, Hong Wei, Warren Strober, Liping Zhao, Guangxun Meng
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Inflammasomes are involved in gut homeostasis and inflammatory pathologies. The authors show that a hyperactive NLRP3 inflammasome maintains gut homeostasis through remodelling of the gut microbiota and induction of regulatory T cells.
Externí odkaz:
https://doaj.org/article/f97bce19ba0642ea8e7aaf262df4cb10
Autor:
Jing Wang, Pupu Ge, Lihua Qiang, Feng Tian, Dongdong Zhao, Qiyao Chai, Mingzhao Zhu, Rongbin Zhou, Guangxun Meng, Yoichiro Iwakura, George Fu Gao, Cui Hua Liu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Mycobacterium tuberculosis secretes a protein, PtpA, that dephosphorylates proteins in the host cell cytoplasm, weakening immune responses. Here, the authors show that PtpA also enters the nucleus, affects the expression of several host genes, and pr
Externí odkaz:
https://doaj.org/article/465a63bc5e6745cab574ea4a454e9961
Autor:
Rongrong Ren, Shuxian Wu, Jialin Cai, Yuqin Yang, Xiaonan Ren, Yanling Feng, Lixiang Chen, Boyin Qin, Chunhua Xu, Hua Yang, Zhigang Song, Di Tian, Yunwen Hu, Xiaohui Zhou, Guangxun Meng
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The avian origin influenza A virus (IAV) H7N9 has caused a considerable number of human infections associated with high rates of death since its emergence in 2013. As a vital component of the host innate immune system, the nucleotide-binding
Externí odkaz:
https://doaj.org/article/e130a582158a4b9793309e0045886d09
Autor:
Lih-Wen Deng, Peipei Zhou, Lulu Liu, Xiaodan Ding, Guangxun Meng, Xinhui Hui, Bin Li, Fajian Hou, Xiujie Yuan, Jin Zhong, Hui Xiao, Xiaoling Wan, Wei Zhang, Yan Zhang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Trithorax group protein MLL5 is an important epigenetic modifier that controls cell cycle progression, chromatin architecture maintenance, and hematopoiesis. However, whether MLL5 has a role in innate antiviral immunity is largely unknown. Here we sh
Autor:
Rongbin Zhou, Qiyao Chai, Yoichiro Iwakura, Feng Tian, Lihua Qiang, George F. Gao, Guangxun Meng, Jing Wang, Dongdong Zhao, Mingzhao Zhu, Cui Hua Liu, Pupu Ge
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Mycobacterium tuberculosis PtpA is a secreted effector protein that dephosphorylates several proteins in the host cell cytoplasm, such as p-JNK, p-p38, and p-VPS33B, leading to suppression of host innate immunity. Here we show that, in addition, PtpA
Autor:
Boyin Qin, Yanling Feng, Xiaonan Ren, Yuqin Yang, Shuxian Wu, Rongrong Ren, Jialin Cai, Zhigang Song, Yunwen Hu, Lixiang Chen, Xiaohui Zhou, Di Tian, Guangxun Meng, Hua Yang, Chunhua Xu
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Scientific Reports
The avian origin influenza A virus (IAV) H7N9 has caused a considerable number of human infections associated with high rates of death since its emergence in 2013. As a vital component of the host innate immune system, the nucleotide-binding domain l