Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Fernando Souza-Fonseca-Guimaraes"'
Autor:
Rebecca J. Austin, Jasmin Straube, Rohit Halder, Yashaswini Janardhanan, Claudia Bruedigam, Matthew Witkowski, Leanne Cooper, Amy Porter, Matthias Braun, Fernando Souza-Fonseca-Guimaraes, Simone A. Minnie, Emily Cooper, Sebastien Jacquelin, Axia Song, Tobias Bald, Kyohei Nakamura, Geoffrey R. Hill, Iannis Aifantis, Steven W. Lane, Megan J. Bywater
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Acute myeloid leukemia (AML) is a genetically heterogeneous, aggressive hematological malignancy induced by distinct oncogenic driver mutations. The effect of specific AML oncogenes on immune activation or suppression is unclear. Here, we ex
Externí odkaz:
https://doaj.org/article/1fe1b18939ee4e878a49fa928f9e503d
Autor:
Emma V. Petley, Hui-Fern Koay, Melissa A. Henderson, Kevin Sek, Kirsten L. Todd, Simon P. Keam, Junyun Lai, Imran G. House, Jasmine Li, Magnus Zethoven, Amanda X. Y. Chen, Amanda J. Oliver, Jessica Michie, Andrew J. Freeman, Lauren Giuffrida, Jack D. Chan, Angela Pizzolla, Jeffrey Y. W. Mak, Timothy R. McCulloch, Fernando Souza-Fonseca-Guimaraes, Conor J. Kearney, Rosemary Millen, Robert G. Ramsay, Nicholas D. Huntington, James McCluskey, Jane Oliaro, David P. Fairlie, Paul J. Neeson, Dale I. Godfrey, Paul A. Beavis, Phillip K. Darcy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mucosal-associated invariant T (MAIT) cells facilitate anti-microbial responses, but their functions in cancer protection is unclear. Here the authors show that activated MAIT cells induce an IFN-γ transcriptome in natural killer (NK) cells and enha
Externí odkaz:
https://doaj.org/article/01f893fc7b8b403cadf95ab8ec274a3e
Autor:
Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby
Externí odkaz:
https://doaj.org/article/289da6d10257442191a1c6fe56d983a8
Autor:
Malcolm J. McConville, Fernando Souza-Fonseca-Guimaraes, Motti Gerlic, Komal Kanojia, Adele Preaudet, Benjamin T. Kile, Marcel R. de Zoete, Man Lyang Kim, Konstantinos A. Kouremenos, Yasunori Ogura, Richard A. Flavell, David P De Souza, Cassandra R. Harapas, Tracy L Putoczki, Stephen Wilcox, Hazel Tye, Seth L. Masters, Graham L. Radford-Smith, Sinéad C. Corr, Martha Zakrzewski, Jocelyn Sietsma Penington, Leesa F. Wockner, Chien-Hsiung Yu, Anthony T. Papenfuss, Lisa A. Simms, Lisa A. Mielke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications, 9(1). Nature Publishing Group
Nature Communications, 9(1). Nature Publishing Group
Anti-microbial signaling pathways are normally triggered by innate immune receptors when detecting pathogenic microbes to provide protective immunity. Here we show that the inflammasome sensor Nlrp1 aggravates DSS-induced experimental mouse colitis b