Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Davide Trotti"'
Autor:
Chiara Scopa, Samantha M. Barnada, Maria E. Cicardi, Mo Singer, Davide Trotti, Marco Trizzino
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of Alzheimer’s disease (AD). Mobilization of transposable elements (TEs) in heterochromatic regions was recently reported in AD, but the underlying mech
Externí odkaz:
https://doaj.org/article/4512ae3de9b742d5a9a921bd03292325
Autor:
Amanda M. Gleixner, Brandie Morris Verdone, Charlton G. Otte, Eric N. Anderson, Nandini Ramesh, Olivia R. Shapiro, Jenna R. Gale, Jocelyn C. Mauna, Jacob R. Mann, Katie E. Copley, Elizabeth L. Daley, Juan A. Ortega, Maria Elena Cicardi, Evangelos Kiskinis, Julia Kofler, Udai B. Pandey, Davide Trotti, Christopher J. Donnelly
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
ALS and FTLD are both characterized by insoluble cytoplasmic depositions of TDP43. Here the authors show that the nucleopore protein NUP62 is mislocalized in C9orf72 and sporadic ALS/FTLD and propose that it interacts with TDP-43 to promote its insol
Externí odkaz:
https://doaj.org/article/04c38fed278645e2a4a1f52a4ea229f4
Autor:
Brandie Morris Verdone, Maria Elena Cicardi, Xinmei Wen, Sindhu Sriramoji, Katelyn Russell, Shashirekha S. Markandaiah, Brigid K. Jensen, Karthik Krishnamurthy, Aaron R. Haeusler, Piera Pasinelli, Davide Trotti
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Translation of the hexanucleotide G4C2 expansion associated with C9orf72 amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) produces five different dipeptide repeat protein (DPR) species that can confer toxicity. There is ye
Externí odkaz:
https://doaj.org/article/19ca21d95d3242fdb4694723b5e2de9e