Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Daniel, H Geschwind"'
Autor:
Sree Deepthi Muthukrishnan, Riki Kawaguchi, Pooja Nair, Rachna Prasad, Yue Qin, Maverick Johnson, Qing Wang, Nathan VanderVeer-Harris, Amy Pham, Alvaro G. Alvarado, Michael C. Condro, Fuying Gao, Raymond Gau, Maria G. Castro, Pedro R. Lowenstein, Arjun Deb, Jason D. Hinman, Frank Pajonk, Terry C. Burns, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Therapeutic stress induces phenotypic plasticity in glioma stem cells although the mechanisms underlying this remain poorly understood. Here, the authors show that P300 mediates the radiation-induced vascular-like conversion of glioma stem cells to p
Externí odkaz:
https://doaj.org/article/2f813af486a84bc6939ddacebcf2e7f8
Autor:
Ngan Pan Bennett Au, Gajendra Kumar, Pallavi Asthana, Fuying Gao, Riki Kawaguchi, Raymond Chuen Chung Chang, Kwok Fai So, Yang Hu, Daniel H. Geschwind, Giovanni Coppola, Chi Him Eddie Ma
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-16 (2022)
Abstract Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system (CNS) are unable to regrow after injury. Here, we demonstrated that Lycium barbarum polysacchar
Externí odkaz:
https://doaj.org/article/59d7549c2a1b4038917bf05b09f9ef36
Autor:
Jing-Ping Lin, Hannah M. Kelly, Yeajin Song, Riki Kawaguchi, Daniel H. Geschwind, Steven Jacobson, Daniel S. Reich
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Studies of cell heterogeneity in white matter in primates have been limited to date. Here the authors describe a marmoset brain cell atlas that bridges rodent and human data, revealing strong gray-white matter glial segregation.
Externí odkaz:
https://doaj.org/article/5acbadad11ce435dbd202e080adc66cb
Autor:
Yuyan Cheng, Yuqin Yin, Alice Zhang, Alexander M. Bernstein, Riki Kawaguchi, Kun Gao, Kyra Potter, Hui-Ya Gilbert, Yan Ao, Jing Ou, Catherine J. Fricano-Kugler, Jeffrey L. Goldberg, Zhigang He, Clifford J. Woolf, Michael V. Sofroniew, Larry I. Benowitz, Daniel H. Geschwind
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Here the authors couple an integrative genomic analysis with substantial in vitro and in vivo experimental validation, identifying REST as a novel suppressor of a pro-regenerative gene program and CNS axon regeneration in mice.
Externí odkaz:
https://doaj.org/article/df6521e5d58e42ea8efb14302c66060b
Autor:
Stefano Berto, Alex H. Treacher, Emre Caglayan, Danni Luo, Jillian R. Haney, Michael J. Gandal, Daniel H. Geschwind, Albert A. Montillo, Genevieve Konopka
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Gene expression patterns have been associated with functional activity patterns in the brain. Here the authors determine how gene expression patterns in the human brain supports brain phenotypes obtained from resting state fMRI imaging, identifying b
Externí odkaz:
https://doaj.org/article/c0365749565041e9b1397c72558560d0
Autor:
Morten Dybdahl Krebs, Gonçalo Espregueira Themudo, Michael Eriksen Benros, Ole Mors, Anders D. Børglum, David Hougaard, Preben Bo Mortensen, Merete Nordentoft, Michael J. Gandal, Chun Chieh Fan, Daniel H. Geschwind, Andrew J. Schork, Thomas Werge, Wesley K. Thompson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Schizophrenia is a complex disorder where individuals experience different symptoms and outcomes that can be captured by patterns in other diagnoses. Here the authors use computational approaches to summarize these patterns and suggest they are assoc
Externí odkaz:
https://doaj.org/article/219901d0dd4a433c9949807e8340f338
Autor:
Jiwen Li, Lin Pan, William G. Pembroke, Jessica E. Rexach, Marlesa I. Godoy, Michael C. Condro, Alvaro G. Alvarado, Mineli Harteni, Yen-Wei Chen, Linsey Stiles, Angela Y. Chen, Ina B. Wanner, Xia Yang, Steven A. Goldman, Daniel H. Geschwind, Harley I. Kornblum, Ye Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Astrocytes are important players in brain development, homeostasis, and disease. Here, the authors compare the transcriptional profiles of human and mouse astrocytes. They report species-specific susceptibility to oxidative stress and response to hyp
Externí odkaz:
https://doaj.org/article/80da4dfa224845c2a806b159e42df65d
Autor:
Benxia Hu, Hyejung Won, Won Mah, Royce B. Park, Bibi Kassim, Keeley Spiess, Alexey Kozlenkov, Cheynna A. Crowley, Sirisha Pochareddy, The PsychENCODE Consortium, Yun Li, Stella Dracheva, Nenad Sestan, Schahram Akbarian, Daniel H. Geschwind
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to ch
Externí odkaz:
https://doaj.org/article/58d534607fbd40f0b3a815f520ae49df
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease defined by motor neuron (MN) loss. Multiple genetic risk factors have been identified, implicating RNA and protein metabolism and intracellular transport, among other biologi
Externí odkaz:
https://doaj.org/article/57ce8c4e63e04689a29f9c91424b88b9
Autor:
Jakob Seidlitz, Ajay Nadig, Siyuan Liu, Richard A. I. Bethlehem, Petra E. Vértes, Sarah E. Morgan, František Váša, Rafael Romero-Garcia, François M. Lalonde, Liv S. Clasen, Jonathan D. Blumenthal, Casey Paquola, Boris Bernhardt, Konrad Wagstyl, Damon Polioudakis, Luis de la Torre-Ubieta, Daniel H. Geschwind, Joan C. Han, Nancy R. Lee, Declan G. Murphy, Edward T. Bullmore, Armin Raznahan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-6 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/d0bdd09f23ba4f6da0f8d58af3616361