Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Andreas Villunger"'
Autor:
Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell surv
Externí odkaz:
https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
Autor:
Eleonora Ottina, Victor Peperzak, Katia Schoeler, Emma Carrington, Roswitha Sgonc, Marc Pellegrini, Simon Preston, Marco J. Herold, Andreas Strasser, Andreas Villunger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tet-transactivators are used for direct regulation of gene expression, RNA interference and for CRISPR/Cas9-based systems. Here the authors show that DNA-bound Tet-transactivators can induce cell death in antigen-activated lymphocytes in vivo, puttin
Externí odkaz:
https://doaj.org/article/28a3c17a5020441bb28ab5bc1d8548fa
Autor:
Muhammet F. Gulen, Ute Koch, Simone M. Haag, Fabian Schuler, Lionel Apetoh, Andreas Villunger, Freddy Radtke, Andrea Ablasser
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The cGAS/STING signalling pathway is responsible for sensing intracellular DNA and activating downstream inflammatory genes. Here the authors show mouse primary T cells and T leukaemia are hyperresponsive to STING agonist, and this strong STING signa
Externí odkaz:
https://doaj.org/article/dd0445dd4e334afc9d468d8ec62cb61e