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Autor:
Dina K Gaynullina, Lyubov D Shilova, Olga S. Tarasova, Ekaterina K Selivanova, Anastasia A. Shvetsova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Intrauterine growth restriction (IUGR) is one of the most common pathologies of pregnancy. The cardiovascular consequences of IUGR do not disappear in adulthood and can manifest themselves in pathological alterations of vasomotor control. The hypothe
Autor:
T. García, Juan de la Cámara Gómez, Alberto Carmona-Bayonas, Marta Covela Rúa, Francisca Vázquez Rivera, Paula Jiménez-Fonseca, Manuel Cánovas, Ana Montes, Carmen Carriles Fernández, Paula Gonzalez Villarroel, Nieves Martinez Lago, Antía Cousillas Castiñeiras, J. Méndez
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Trifluridine/tipiracil increases overall survival (OS) in patients with refractory, metastatic colorectal cancer (mCRC). A post hoc exploratory analysis of the RECOURSE randomized clinical trial (RCT) established two categories, a good prognosis corr
Autor:
Robert H. Mak, Hal M. Hoffman, Sheng Hao, Wai W. Cheung, Zhen Wang, Ronghao Zheng, Alex Gonzalez, Ping Zhou
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was induced by 5/6 nephrectomy in mice. We studied energy homeostasis in Il1β
Autor:
Neha Seth, Amy Minnema, Miguel Hernandez Pampaloni, Amy Viehoever, Toni S. Pearson, Waldy San Sebastian, Ana Grijalvo-Perez, Shannon Lundy, Erin Smith, Russell R. Lonser, Krystof S. Bankiewicz, Jill Imamura-Ching, J. Bradley Elder, Jeffrey R. Leonard, Youngho Seo, Jill C. Heathcock, Keith Hyland, Gardenia de Oliveira Barbosa, Paul S. Larson, Alex J. Fay, Nalin Gupta
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in early infancy, and causes severe developmental disability and lifelong motor, behavioral,
Autor:
Kai Duan, Steven Gallinger, Julie M. Wilson, Faiyaz Notta, Sandra Fischer, Gun-Ho Jang, Robert C. Grant, Jennifer J. Knox, Grainne M. O'Kane
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific Reports
Scientific Reports
Combination chemotherapy, either modified FOLFIRINOX (mFFX) or gemcitabine–nabpaclitaxel, are used in the treatment of most patients with advanced pancreatic ductal adenocarcinoma (PDAC), yet robust biomarkers of outcome are currently lacking to gu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Heart rate (HR) and sinoatrial node (SAN) function are modulated by the autonomic nervous system. HR regulation by the parasympathetic nervous system (PNS) is impaired in diabetes mellitus (DM), which is denoted cardiovascular autonomic neuropathy. W
Autor:
Jeng-Sen Tseng, Jeremy J.W. Chen, Sung-Liang Yu, Gee-Chen Chang, Kuo-Hsuan Hsu, Tsung-Ying Yang, Kang-Yi Su, Yen-Hsiang Huang, Kun-Chieh Chen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The impact of different first-line epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)s to the clinical efficacy of osimertinib in EGFR-mutant non-small-cell lung cancer (NSCLC) patients with acquired T790M was still unclear. We e
Autor:
C. Alejandra Monraz-Méndez, Rebeca Escutia-Gutiérrez, Ana Sandoval-Rodriguez, Juan Armendáriz-Borunda, Arturo Santos-Garcia, J. Samael Rodríguez-Sanabria, Jesús García-Bañuelos
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
miRNAs are involved in the development of metabolic associated fatty liver disease (MAFLD) and nonalcoholic steatohepatitis (NASH). We aimed to evaluate modifications by prolonged-release pirfenidone (PR-PFD) on key hepatic miRNAs expression in a MAF
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Meal ingestion elicits a variety of neuronal, physiological and hormonal responses that differ in healthy, obese or diabetic individuals. The mixed meal tolerance test (MMTT) is a well-established method to evaluate pancreatic β-cell reserve and glu
Autor:
Harriet de Wit, Bernard Le Foll, Isabelle Boileau, Patricia Di Ciano, Sylvain Houle, Esmaeil Mansouri
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports
Scientific Reports
Stimuli previously paired with drugs of dependence can produce cravings that are associated with increased dopamine (DA) levels in limbic and striatal brain areas. Positron Emission Tomography (PET) imaging with [11C]-(+)-PHNO allows for a sensitive