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Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 96(7):3934-3939
The function(s) of the genes ( PKD1 and PKD 2) responsible for the majority of cases of autosomal dominant polycystic kidney disease is unknown. While PKD1 encodes a large integral membrane protein containing several structural motifs found in known
A primary method for studying cellular function is to examine cell morphology after a given manipulation. Fluorescent markers attached to proteins/intracellular structures of interest in conjunction with 3D fluorescent microscopy are frequently explo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c15848af56646bf483adaf974f5e5d
https://europepmc.org/articles/PMC3365204/
https://europepmc.org/articles/PMC3365204/
Autor:
Natasha Kyprianou
A single nucleotide polymorphism in the DAB2IP gene is associated with risk of aggressive prostate cancer (PCa), and loss of DAB2IP expression is frequently detected in metastatic PCa. However, the functional role of DAB2IP in PCa remains unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc469349cf5c6d4f74db24578a2fb8e
https://europepmc.org/articles/PMC2840332/
https://europepmc.org/articles/PMC2840332/
Autor:
Hunaiz Patel, Victor Adler, Ehsan Sarafraz-Yazdi, Vernon Wu, Josef Michl, Matthew R. Pincus, Wilbur B. Bowne, Paul W. Brandt-Rauf, Kelley A. Sookraj, Michael E. Zenilman, Vadim Shteyler, William Oxbury
The anticancer peptide PNC-27, which contains an HDM-2-binding domain corresponding to residues 12-26 of p53 and a transmembrane-penetrating domain, has been found to kill cancer cells (but not normal cells) by inducing membranolysis. We find that ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3234eb36b1e1ab8c05a30028d6a6c6e1
https://europepmc.org/articles/PMC2836618/
https://europepmc.org/articles/PMC2836618/
Autor:
Sai K. Saridey, Matthew H. Wilson, Alfred L. George, Aparna Kaja, Melissa A. Daniels, Kristopher M. Kahlig
Generation of cultured human cells stably expressing one or more recombinant gene sequences is a widely used approach in biomedical research, biotechnology, and drug development. Conventional methods are not efficient and have severe limitations espe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d50a2a91c8c3d1c7a9f23718de04616
https://europepmc.org/articles/PMC2824351/
https://europepmc.org/articles/PMC2824351/
Autor:
Philip J. Santangelo, Nicole A. Ducharme, James R. Goldenring, James E. Crowe, Bryan E. Shepherd, Thomas J. Utley, Michael E. Lindquist, Vasundhara Varthakavi
Respiratory syncytial virus (RSV) infects polarized epithelia, which have tightly regulated trafficking because of the separation and maintenance of the apical and basolateral membranes. Previously we established a link between the apical recycling e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927e409d46a240fa81f593e294b0e11f
https://europepmc.org/articles/PMC2481327/
https://europepmc.org/articles/PMC2481327/
Autor:
Johan Ericson, Maria V. Gustafsson, Xiaofeng Zheng, Jeffrey J. Gorman, Sarah Linke, Murray L. Whitelaw, Brett Hamilton, Katarina Gradin, Teresa Pereira, Xiaowei Zheng, José M. Dias, Kerstin Brismar, Tristan P. Wallis, Lorenz Poellinger, Jorge L. Ruas, Sarah E. Wilkins, Urban Lendahl, Daniel J. Peet, Rebecca Louise Bilton
Cells adapt to hypoxia by a cellular response, where hypoxia-inducible factor 1α (HIF-1α) becomes stabilized and directly activates transcription of downstream genes. In addition to this “canonical” response, certain aspects of the pathway requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0709b38e95906f7ef4ba97687c97b8
https://europepmc.org/articles/PMC2265116/
https://europepmc.org/articles/PMC2265116/
The numerous steps in protein gene expression are extensively coupled to one another through complex networks of physical and functional interactions. Indeed, >25 coupled reactions, often reciprocal, have been documented among such steps as transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39a086ebd87b5db9a9f96cc2c2dea14
https://europepmc.org/articles/PMC2265164/
https://europepmc.org/articles/PMC2265164/
In vitro antibody affinity maturation has generally been achieved by display of mouse or human antibodies on the surface of microorganisms (phage, bacteria, and yeast). However, problems with protein folding, posttranslational modification, and codon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e034e7ee499370566ee13b162621ce7
https://europepmc.org/articles/PMC1480459/
https://europepmc.org/articles/PMC1480459/
Proteins containing a caspase recruitment domain (CARD) play pivotal roles in signal transduction leading to apoptosis and NF-κB activation and inflammation. Here we identify and characterize human and mouse CARD protein 6 (CARD6), CARD-containing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5808fb208749ffcdff6c52864169eec
https://europepmc.org/articles/PMC1327733/
https://europepmc.org/articles/PMC1327733/