Zobrazeno 1 - 10
of 73
pro vyhledávání: ''
Autor:
Jeremy N. Rich, Zengqiang Yuan, Rong Wu, Qi Xie, Xiao-Song Chen, Yuhao Gao, Qing He, Liang Wang, Kun-Wei Shen, Ryan C. Gimple, Yajin Liao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Adipocytes are the most abundant and perhaps most active components of the tumor microenvironment in obese individuals that potentiate breast tumorigenesis through secretory mechanisms. The modulation of adipocytes can be novel therapy t
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Recently, the field of Parkinson’s disease biology has shifted attention away from pure proteinotoxic hypotheses to emphasize primary cellular insults, including glycolipid disturbances. In this work, dopaminergic neurons in the Parkin
Autor:
Hongbo Hu, Shiqian Qi, Huiyuan Zhang, Tingting Yang, Zhonghan Li, Qing-Yuan Sun, Yike Yin, Huancheng Fu, Dan Tang, Wenming Xu, Xueying Fan, Jingfei Xiong, Biao Dong, Qiuyue Huang, Lunzhi Dai, Yuliang Liu, Kun Xie, Shiyu Cao, Fuping Li, Tie-Gang Meng, Ling Nie, Yu Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance NOD-like receptors (NLRs) are traditionally recognized as key surveillance pattern recognition receptors (PRRs) during innate immune regulation. Several NLRs exhibit highly restricted expression in mammalian germline, where their physiol
Autor:
Rui Zhao, Jing Zhang, Lei Shi, Ning Zhu, Aihong Mao, Yuxin Wang, Jing Nan, Yuping Du, Xing Chen, Zhao Zhang, Xinxin Zhang, Yuxi Lin, Jinbo Yang, George R. Stark, Wei Wei, Jingjie Sun, Ruidong Miao, Xin Li, Xiaodong Qin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Tamoxifen is beneficial in treating estrogen receptor–positive breast cancer, but resistance to this treatment eventually ensues. A method to identify mechanisms of tamoxifen resistance identified the histone deacetylase ZIP, leading t
Autor:
Marina Kazantseva, Diego Alvarez de la Rosa, Michael Jennings, Daniel Barth, Martin Fronius, Norbert Weissmann, Eng Leng Saw, Rajesh Katare, Jan-Peter Baldin, Fenja Knoepp, Zoe Ashley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The ability to sense mechanical forces is essential for all living organisms. Extracellular tethers have been proposed to mediate mechanical activation of channels belonging to the epithelial Na+ channel (ENaC)/degenerin protein family.
Autor:
Yu, Jia, Shi, Yue, Zhao, Kaixuan, Yang, Guang, Yu, Lina, Li, Yuxin, Andersson, Eva-Marie, Ämmälä, Carina, Yang, Shao-Nian, Berggren, Per-Olof
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We reveal that increased expression of CaV3.1 channels in rat islets selectively impairs first-phase glucose-stimulated insulin secretion. This deterioration is recapitulated in human islets. Its causal role in diabetes development is cl
Autor:
Jelena S. Bezbradica, Linda F. M. Mies, Jonathan C. Kagan, S Danielli, Eirini Pantazi, Benjamin Demarco, Michelle Sue Jann Lee, Cevayir Coban, Michael Ohlmeyer, Elena Di Daniel, Sohaib Nizami, Fabian A. Fischer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The NLRP3 inflammasome is an innate sensor activated by signals released from pathogens or injured tissues. Activation of the NLRP3 inflammasome can be beneficial during infection and vaccination. Nonetheless, when NLRP3 activity is unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca17ad0248e5b7d104b0c6b69873e49b
https://doi.org/10.1073/pnas.2009309118
https://doi.org/10.1073/pnas.2009309118
Autor:
Allison Banuelos, Anna Shcherbina, Jingling Li, Kristopher D. Marjon, Sravani Banerjee, Irving L. Weissman, Jing Bian, Cyndhavi Narayanan, Thomas Brickler, Sundari Chetty
Publikováno v:
Proc Natl Acad Sci U S A
Copy number variation (CNV) at the 16p11.2 locus is associated with neuropsychiatric disorders, such as autism spectrum disorder and schizophrenia. CNVs of the 16p gene can manifest in opposing head sizes. Carriers of 16p11.2 deletion tend to have ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af405024451460dc5b6849fb847a8c66
https://europepmc.org/articles/PMC8053942/
https://europepmc.org/articles/PMC8053942/
Autor:
Alan Le Mercier, Weijia Yu, Boris Strilic, Remy Bonnavion, Yannick Jäger, Xinyi Chen, Hyun-Woo Jeong, Mohamad Wessam Alnouri, Michael A. Rieger, Yang Zhang, Stefan Offermanns, Sophie Ramas, Kishor K. Sivaraj, Tjeerd Sijmonsma, Haaglim Cho, Timm Schroeder, Ralf H. Adams, Kenneth Anthony Roquid
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 118 (17)
Proceedings of the National Academy of Sciences of the United States of America, 118 (17)
G protein–coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. We found GPR182 to be expressed in microvascular and lymphatic endothelial cells of most o
Autor:
Anthony J. Griswold, Giacomo Lanzoni, Camillo Ricordi, Kevin R. Johnson, Michael T. García, Juan Domínguez-Bendala, Ángela Díaz, Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Dagmar Klein, Ricardo L. Pastori, Saad Sadiq, David W. Sant, Jasmijn van Dijk, Belén Navarro-Rubio, Yaisa B. Moreno-Hernández, Rocío Muñiz-Anquela
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance The existence of progenitors within pancreatic ducts has been studied for decades, but the hypothesis that they may help regenerate the adult endocrine compartment (chiefly insulin-producing β-cells) remains contentious. Here, we examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9f24e2a83dbe29d38cd4534024c497
https://europepmc.org/articles/PMC8017669/
https://europepmc.org/articles/PMC8017669/