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A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice
Autor:
Taisuke Horimoto, Tomoya Kobayashi, Hiroho Ishida, Hiromichi Matsugo, Haruhiko Kamiki, Akiko Takenaka-Uema, Shin Murakami
Publikováno v:
Viruses
Volume 10
Issue 11
Viruses, Vol 10, Iss 11, p 653 (2018)
Volume 10
Issue 11
Viruses, Vol 10, Iss 11, p 653 (2018)
H9N2 avian influenza viruses are present in poultry worldwide. These viruses are considered to have pandemic potential, because recent isolates can recognize human-type receptor and several sporadic human infections have been reported. In this study,