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Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5517, p 5517 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5517, p 5517 (2021)
Antipruritic effects of kappa opioid receptor (KOR) agonists have been shown in rodent models of acute and chronic scratching (itchlike behavior). Three KOR agonists, nalfurafine, difelikefalin, and nalbuphine, are in clinical studies for antipruriti
Autor:
Chantal R. Ryan, Jensen E. Murphy, Rebecca E. K. MacPherson, Michael S. Finch, Tyler Dunham, Brian D. Roy
Publikováno v:
Nutrients
Volume 13
Issue 7
Nutrients, Vol 13, Iss 2406, p 2406 (2021)
Volume 13
Issue 7
Nutrients, Vol 13, Iss 2406, p 2406 (2021)
White adipose tissue (WAT) is a dynamic endocrine organ that can play a significant role in thermoregulation. WAT has the capacity to adopt structural and functional characteristics of the more metabolically active brown adipose tissue (BAT) and cont
Publikováno v:
Molecules
Volume 26
Issue 1
Molecules, Vol 26, Iss 56, p 56 (2021)
Volume 26
Issue 1
Molecules, Vol 26, Iss 56, p 56 (2021)
The androgen receptor (AR) is a pivotal target for the treatment of prostate cancer (PC) even when the disease progresses toward androgen-independent or castration-resistant forms. In this study, a series of 15 bicalutamide analogues (sulfide, deshyd
Publikováno v:
Nutrients
Volume 12
Issue 9
Nutrients, Vol 12, Iss 2518, p 2518 (2020)
Volume 12
Issue 9
Nutrients, Vol 12, Iss 2518, p 2518 (2020)
We assessed the effect of different doses of vitamin D supplementation on microcirculation, signs and symptoms of peripheral neuropathy and inflammatory markers in patients with type 2 diabetes (T2DM). Sixty-seven patients with T2DM and peripheral ne
Publikováno v:
Nutrients
Volume 12
Issue 4
Nutrients, Vol 12, Iss 1176, p 1176 (2020)
Volume 12
Issue 4
Nutrients, Vol 12, Iss 1176, p 1176 (2020)
Background: Dietary supplements purported to increase circulating nitric oxide are very popular among consumers. We determined the acute impact of two novel dietary supplements on plasma nitrate/nitrite (NOx) and nitrite alone. Methods: 20 men and wo
Publikováno v:
Nutrients
Volume 11
Issue 12
NUTRIENTS
Volume 11
Issue 12
NUTRIENTS
Personalised dosing of performance-enhancing food supplements is a hot topic. &beta
alanine is currently dosed using a fixed dose
however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose see
alanine is currently dosed using a fixed dose
however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose see
Publikováno v:
Biomolecules
Volume 9
Issue 9
Biomolecules, Vol 9, Iss 9, p 441 (2019)
Volume 9
Issue 9
Biomolecules, Vol 9, Iss 9, p 441 (2019)
Alzheimer&rsquo
s disease (AD) is a neurodegenerative disease characterized by a cascade of changes in cognitive, behavioral, and social activities. Several areas of the brain are involved in the regulation of memory. Of most importance are the
s disease (AD) is a neurodegenerative disease characterized by a cascade of changes in cognitive, behavioral, and social activities. Several areas of the brain are involved in the regulation of memory. Of most importance are the
Autor:
Paola Corona, Gabriele Murineddu, Laura Legnani, Gérard Aimé Pinna, Lucio Toma, Stefania Ruiu, Paolo Lazzari, Battistina Asproni, Sandra Piras
Publikováno v:
Molecules
Volume 24
Issue 9
Molecules, Vol 24, Iss 9, p 1656 (2019)
Volume 24
Issue 9
Molecules, Vol 24, Iss 9, p 1656 (2019)
In this work, the synthesis of the cannabinoid receptor 1 neutral antagonists 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4,5-dihydrobenzo-1H-6-oxa-cyclohepta[1,2-c]pyrazole-3-carboxamide 1a and its deaza N-cyclohexyl analogue 1b has led to a de
Autor:
David Stepensky, Esther Paran, Karin Linnewiel-Hermoni, Yoav Sharoni, Talia Wolak, Joseph Levy
Publikováno v:
Nutrients
Volume 11
Issue 5
Nutrients, Vol 11, Iss 5, p 950 (2019)
Volume 11
Issue 5
Nutrients, Vol 11, Iss 5, p 950 (2019)
Oxidative stress is implicated in the pathogenesis of essential hypertension, a risk factor for cardiovascular morbidity and mortality. Tomato carotenoids such as lycopene and the colorless carotenoids phytoene and phytofluene induce the antioxidant
Autor:
Juan C Machado-Rodriguez, Yair Alvarez-Ricardo, Raúl G. Enríquez, William Meza-Morales, Manuel Soriano-García, Marco A. Obregón-Mendoza, Julia Cassani, Rubén A. Toscano, Antonio Nieto-Camacho
Publikováno v:
Molecules
Volume 24
Issue 5
Molecules, Vol 24, Iss 5, p 910 (2019)
Volume 24
Issue 5
Molecules, Vol 24, Iss 5, p 910 (2019)
We report herein the synthesis and crystal structures of five new homoleptic copper complexes of curcuminoids. The scarcity of reports of homoleptic complex structures of curcuminoids is attributed to the lack of crystallinity of such derivatives, an