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Autor:
Michał Oczkowski, Sylwia Męczyńska-Wielgosz, Katarzyna Dziendzikowska, Małgorzata Węsierska, Marcin Kruszewski, Jacek Wilczak, Joanna Gromadzka-Ostrowska
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12706
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12706, p 12706 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12706, p 12706 (2021)
Due to their potent antibacterial properties, silver nanoparticles (AgNPs) are widely used in industry and medicine. However, they can cross the brain–blood barrier, posing a risk to the brain and its functions. In our previous study, we demonstrat
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12698
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12698, p 12698 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12698, p 12698 (2021)
We determined if combined administration of JNK-inhibitors and HGF (hepatocyte-growth-factor) would restore erectile-function through both antiapoptotic and regenerative effects in a rat model of cavernous-nerve-crush-injury (CNCI), and compared the
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12716
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12716, p 12716 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12716, p 12716 (2021)
Telmisartan (TM) has been proposed to relieve inflammatory responses by modulating peroxisome proliferator activator receptor-γ (PPARγ) signaling. This study aimed to investigate the protective effects of TM on kanamycin(KM)-induced ototoxicity in
Autor:
María Milagros Gómez-Gómez, Óscar Pastor, Estefanía Moreno-Gordaliza, Alberto Lázaro, M.D. Marazuela
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 22
E-Prints Complutense. Archivo Institucional de la UCM
instname
International Journal of Molecular Sciences, Vol 22, Iss 12521, p 12521 (2021)
Volume 22
Issue 22
E-Prints Complutense. Archivo Institucional de la UCM
instname
International Journal of Molecular Sciences, Vol 22, Iss 12521, p 12521 (2021)
Nephrotoxicity is a major complication of cisplatin-based chemotherapy, leading to acute kidney injury in ca. 30% of patients, with no preventive intervention or treatment available for clinical use. Cilastatin has proved to exert a nephroprotective
Autor:
Dalal Alhashmialameer, Sumera Zaib, Ajmal Khan, Faisal Usman, Jahanzeb Mudassir, Gaber El-Saber Batiha, Sirikhwan Manee, Khamael M. Abualnaja, Imtiaz Khan, Hamid Saeed Shah
Publikováno v:
Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6633, p 6633 (2021)
Volume 26
Issue 21
Molecules, Vol 26, Iss 6633, p 6633 (2021)
Type 2 diabetes mellitus has been a major health issue with increasing morbidity and mortality due to macrovascular and microvascular complications. The urgent need for improved methods to control hyperglycemic complications reiterates the developmen
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, MDPI, 2021, 22 (21), pp.11759. ⟨10.3390/ijms222111759⟩
International Journal of Molecular Sciences, Vol 22, Iss 11759, p 11759 (2021)
Volume 22
Issue 21
International Journal of Molecular Sciences, MDPI, 2021, 22 (21), pp.11759. ⟨10.3390/ijms222111759⟩
International Journal of Molecular Sciences, Vol 22, Iss 11759, p 11759 (2021)
International audience; Microgravity, one of the conditions faced by astronauts during spaceflights, triggers brain adaptive responses that could have noxious consequences on behaviors. Although monoaminergic systems, which include noradrenaline (NA)
Autor:
Irina Koryakina, Mikhail V. Zyuzin, Vadim Elagin, Daria S. Kuznetsova, Maria M. Karabut, Svetlana A. Rodimova, Alexander S. Timin, Vladimir E. Zagainov, Elena V. Zagaynova
Publikováno v:
Cells
Volume 10
Issue 11
Cells, Vol 10, Iss 2894, p 2894 (2021)
Volume 10
Issue 11
Cells, Vol 10, Iss 2894, p 2894 (2021)
The search for new criteria indicating acute or chronic pathological processes resulting from exposure to toxic agents, testing of drugs for potential hepatotoxicity, and fundamental study of the mechanisms of hepatotoxicity at a molecular level stil
Geraniol Averts Methotrexate-Induced Acute Kidney Injury via Keap1/Nrf2/HO-1 and MAPK/NF-κB Pathways
Publikováno v:
Current Issues in Molecular Biology
Volume 43
Issue 3
Pages 123-1755
Current Issues in Molecular Biology, Vol 43, Iss 123, Pp 1741-1755 (2021)
Volume 43
Issue 3
Pages 123-1755
Current Issues in Molecular Biology, Vol 43, Iss 123, Pp 1741-1755 (2021)
Objectives: Geraniol, a natural monoterpene, is an essential oil component of many plants. Methotrexate is an anti-metabolite drug, used for cancer and autoimmune conditions
however, clinical uses of methotrexate are limited by its concomitant r
however, clinical uses of methotrexate are limited by its concomitant r
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10669, p 10669 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10669, p 10669 (2021)
Ischemia/reperfusion injury (IRI) in the kidney is the most common cause of acute renal dysfunction through different cell damage mechanisms. This study aimed to investigate, on molecular basics for the first time, the effect of pantoprazole on renal
Autor:
S. P. Belova, Tatiana Y. Kostrominova, Ekaterina P. Kalashnikova, Boris Shenkman, Tatiana L. Nemirovskaya, Ksenia A. Zaripova
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10444, p 10444 (2021)
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10444, p 10444 (2021)
Skeletal muscle unloading results in atrophy. We hypothesized that pannexin 1 ATP-permeable channel (PANX1) is involved in the response of muscle to unloading. We tested this hypothesis by blocking PANX1, which regulates efflux of ATP from the cytopl