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Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1351, p 1351 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1351, p 1351 (2021)
The functional suppression of serotonin (5-HT) type 7 receptor (5-HT7R) is forming a basis for scientific discussion in psychopharmacology due to its rapid-acting antidepressant-like action. A novel mood-stabilizing atypical antipsychotic agent, lura
Autor:
Sheng Nan Wu, Bálint Lőrinczi, Yi Ching Lo, Wei Yu Fang, Wan Hsuan Chang, István Szatmári, Chih Lung Lin, Ferenc Fülöp
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1300, p 1300 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1300, p 1300 (2021)
Kynurenic acid (KYNA, 4-oxoquinoline-2-carboxylic acid), an intermediate of the tryptophan metabolism, has been recognized to exert different neuroactive actions
however, the need of how it or its aminoalkylated amide derivative N-(2-(dimethylam
however, the need of how it or its aminoalkylated amide derivative N-(2-(dimethylam
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1141, p 1141 (2021)
Volume 22
Issue 3
International Journal of Molecular Sciences, Vol 22, Iss 1141, p 1141 (2021)
Artemether, an artemisinin derivative, is used in the management of life-threatening severe malaria. This study aimed to develop an intravenous dosage form of artemether using nanotechnology. Artemether-loaded zein nanoparticles were prepared by modi
Autor:
Isao Nagaoka, Koichiro Aihara, Koichi Sato, Hiroshi Tanaka, Toshiaki Iba, Katsuhiko Kadota, Jerrold H. Levy
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 176, p 176 (2021)
Volume 22
Issue 1
International Journal of Molecular Sciences, Vol 22, Iss 176, p 176 (2021)
(1) Background: The endothelial glycocalyx is a primary target during the early phase of sepsis. We previously reported a newly developed recombinant non-fucosylated antithrombin has protective effects in vitro. We further evaluated the effects of th
Autor:
Andreas N. Kavazis, Moon-Hyon Hwang, Ryan N Montalvo, Erin E. Talbert, Oh Sung Kwon, Jeung-Ki Yoo, Vivian Doerr, Demetra D. Christou, Ashley J. Smuder, Branden L. Nguyen
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8105, p 8105 (2020)
Volume 21
Issue 21
International Journal of Molecular Sciences, Vol 21, Iss 8105, p 8105 (2020)
Doxorubicin (DOX) is a highly effective chemotherapeutic agent used in the treatment of various cancer types. Nevertheless, it is well known that DOX promotes the development of severe cardiovascular complications. Therefore, investigation into the u
Autor:
Chika Iwasaki, Takahisa Okubo, Juri Saruta, Masaichi-Chang-il Lee, Makiko Saita, Makoto Hirota, Masakazu Hasegawa, Yasuyoshi Torii, Wonhee Park, Yoshihiko Sugita, Takashi Taniyama, Takahiro Ogawa, Manabu Ishijima, Naser Mohammadzadeh Rezaei, Hatsuhiko Maeda, Miyuki Tanaka, Takeo Sekiya, Masako Tabuchi, Nobuaki Sato
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2405, p 2405 (2020)
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2405, p 2405 (2020)
Poly(methyl methacrylate) (PMMA)-based bone cement, which is widely used to affix orthopedic metallic implants, is considered bio-tolerant but lacks osteoconductivity and is cytotoxic. Implant loosening and toxic complications are significant and rec
Autor:
Hitoshi Yoshiji, Takemi Akahane, Yuki Tsuji, Mitsuteru Kitade, Kei Moriya, Yukihisa Fujinaga, Kosuke Kaji, Yasuhiko Sawada, Daisuke Kaya, Shinya Sato, Soichiro Saikawa, Koh Kitagawa, Masanori Furukawa, Hiroaki Takaya, Akira Mitoro, Keisuke Nakanishi, Tadashi Namisaki, Hideto Kawaratani, Takahiro Ozutsumi, Naotaka Shimozato, Ryuichi Noguchi
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2164 (2020)
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2164 (2020)
Hepatocellular carcinoma (HCC) is the strongest independent predictor of mortality in non-alcoholic steatohepatitis (NASH)-related cirrhosis. The effects and mechanisms of combination of sodium-dependent glucose cotransporter inhibitor and canagliflo
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1945 (2020)
Volume 21
Issue 6
International Journal of Molecular Sciences, Vol 21, Iss 6, p 1945 (2020)
While the descending dopaminergic control system is not fully understood, it is reported that the hypothalamic A11 nucleus is its principle source. To better understand the impact of this system, particularly the A11 nucleus, on neuropathic pain, we
Autor:
Ilkka Pörsti, Päivi Lakkisto, Ilkka Tikkanen, Suvi Törmänen, Onni Niemelä, Arttu Eräranta, Jukka Mustonen, Peeter Kööbi
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 936 (2020)
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 936 (2020)
Chronic renal insufficiency (CRI) is characterized by increased endothelin 1 (ET-1) synthesis. We studied rat kidney endothelin receptor A (ETA) and receptor B (ETB) expressions after 12 and 27 weeks of 5/6 nephrectomy, and after 12 weeks of 0.3% ade
Autor:
Xue Tao, Yong-Hong Liao, Qi Chang, Zhi Wang, Li-Sha Wang, Ruile Pan, Li Feng, Xinmin Liu, Yun-Feng Zhou
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4282 (2019)
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4282 (2019)
An olfactory bulbectomy (OBX) rodent is a widely-used model for depression (especially for agitated depression). The present study aims to investigate the hippocampus metabolic profile and autophagy-related pathways in OBX rats and to explore the mod