Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Anssi Lipponen"'
Autor:
Natallie Kajevu, Anssi Lipponen, Pedro Andrade, Ivette Bañuelos, Noora Puhakka, Elina Hämäläinen, Teemu Natunen, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14049 (2023)
We tested a hypothesis that in silico-discovered compounds targeting traumatic brain injury (TBI)-induced transcriptomics dysregulations will mitigate TBI-induced molecular pathology and augment the effect of co-administered antiseizure treatment, th
Externí odkaz:
https://doaj.org/article/1f3bc2149fe249bdb536c8bf79bb03a8
Autor:
Ananda Tiwari, Sangeet Adhikari, Shuxin Zhang, Tamunobelema B. Solomon, Anssi Lipponen, Md. Aminul Islam, Ocean Thakali, Sarawut Sangkham, Mohamed N. F. Shaheen, Guangming Jiang, Eiji Haramoto, Payal Mazumder, Bikash Malla, Manish Kumar, Tarja Pitkänen, Samendra P. Sherchan
Publikováno v:
Water, Vol 15, Iss 6, p 1018 (2023)
The emergence of new variants of SARS-CoV-2 associated with varying infectivity, pathogenicity, diagnosis, and effectiveness against treatments challenged the overall management of the COVID-19 pandemic. Wastewater surveillance (WWS), i.e., monitorin
Externí odkaz:
https://doaj.org/article/7de5e6f09dcb4a55891845ff1ba4cb8f
Autor:
Anssi Lipponen, Natallie Kajevu, Teemu Natunen, Robert Ciszek, Noora Puhakka, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4116 (2023)
Analysis platforms to predict drug-induced seizure liability at an early phase of drug development would improve safety and reduce attrition and the high cost of drug development. We hypothesized that a drug-induced in vitro transcriptomics signature
Externí odkaz:
https://doaj.org/article/46ba25784dc24975adec02344f432ac5
Autor:
Jenni Kyyriäinen, Natallie Kajevu, Ivette Bañuelos, Leonardo Lara, Anssi Lipponen, Silvia Balosso, Elina Hämäläinen, Shalini Das Gupta, Noora Puhakka, Teemu Natunen, Teresa Ravizza, Annamaria Vezzani, Mikko Hiltunen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10555 (2021)
We assessed the effect of antioxidant therapy using the Food and Drug Administration-approved respiratory drug N-acetylcysteine (NAC) or sulforaphane (SFN) as monotherapies or duotherapy in vitro in neuron-BV2 microglial co-cultures and validated the
Externí odkaz:
https://doaj.org/article/b998370c5ed947969d9f9c88922b1f47
Autor:
Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5395 (2019)
We developed a pipeline for the discovery of transcriptomics-derived disease-modifying therapies and used it to validate treatments in vitro and in vivo that could be repurposed for TBI treatment. Desmethylclomipramine, ionomycin, sirolimus and trimi
Externí odkaz:
https://doaj.org/article/f6399f138e4643869ce0fdf7641b06bc
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 6, p 1259 (2019)
Extracellular vesicles (EVs) are small vesicles involved in intercellular communication. Data is emerging that EVs and their cargo have potential as diagnostic biomarkers and treatments for brain diseases, including traumatic brain injury and epileps
Externí odkaz:
https://doaj.org/article/2e94047ccb86483791a22e745fdf710b