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FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers
Autor:
Katia A. Mesquita, Reem Ali, Rachel Doherty, Michael S. Toss, Islam Miligy, Adel Alblihy, Dorjbal Dorjsuren, Anton Simeonov, Ajit Jadhav, David M. Wilson, Ian Hickson, Natalie J. Tatum, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
Cancers, Vol 13, Iss 8, p 1866 (2021)
FEN1 plays critical roles in long patch base excision repair (LP-BER), Okazaki fragment maturation, and rescue of stalled replication forks. In a clinical cohort, FEN1 overexpression is associated with aggressive phenotype and poor progression-free s
Externí odkaz:
https://doaj.org/article/562f8d9a25af48be922e7f114506d739