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Autor:
Katsumi Fujimoto, Hidemi Kurihara, Masami Kanawa, Tania Saskianti, Yukihito Higashi, Takeshi Kawamoto, Akira Igarashi, Yukio Kato, Ayumu Nakashima
Publikováno v:
Current Issues in Molecular Biology; Volume 43; Issue 3; Pages: 2157-2166
Current Issues in Molecular Biology, Vol 43, Iss 150, Pp 2157-2166 (2021)
Current Issues in Molecular Biology, Vol 43, Iss 150, Pp 2157-2166 (2021)
Mesenchymal stromal cells (MSCs) have the potential to differentiate into a variety of mature cell types and are a promising source of regenerative medicine. The success of regenerative medicine using MSCs strongly depends on their differentiation po
Autor:
Yoshiko Hashimoto, Yoji Hisamatsu, Susumu Tanaka, Hiromi Murata, Hiroaki Tsubokura, Masaaki Kitada, Hidetaka Okada
Publikováno v:
Current Issues in Molecular Biology, Vol 43, Iss 146, Pp 2111-2123 (2021)
Current Issues in Molecular Biology; Volume 43; Issue 3; Pages: 2111-2123
Current Issues in Molecular Biology; Volume 43; Issue 3; Pages: 2111-2123
Cyclic changes, such as growth, decidualization, shedding, and regeneration, in the human endometrium are regulated by the reciprocal action of female hormones, such as estradiol (E2), and progesterone (P4). Matrix metalloproteases (MMPs) and tissue
Autor:
Mari Hämäläinen, Antti Pemmari, Lauri J. Moilanen, Lauri Tuure, Riina Nieminen, Teemu Moilanen, E. Nummenmaa, Eeva Moilanen, Katriina Vuolteenaho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 87, p 87 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
Transient receptor potential ankyrin 1 (TRPA1) is a membrane-bound ion channel found in neurons, where it mediates nociception and neurogenic inflammation. Recently, we have discovered that TRPA1 is also expressed in human osteoarthritic (OA) chondro
Autor:
Ryota Chijimatsu, Takuya Ishimoto, Kenji Takami, Takayoshi Nakano, Kosuke Ebina, Atsushi Goshima, Takashi Kanamoto, Akira Miyama, Yuki Etani, Yasukazu Yonetani, Masayuki Hamada, Gensuke Okamura, Ken Nakata, Makoto Hirao, Hideki Yoshikawa
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 300, p 300 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
Synovial mesenchymal stem cell (SMSC) is the promising cell source of cartilage regeneration but has several issues to overcome such as limited cell proliferation and heterogeneity of cartilage regeneration ability. Previous reports demonstrated that
Publikováno v:
Cells, Vol 10, Iss 3370, p 3370 (2021)
Cells
Cells; Volume 10; Issue 12; Pages: 3370
Cells
Cells; Volume 10; Issue 12; Pages: 3370
Subtype-specific human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are promising tools, e.g., to assess the potential of drugs to cause chronotropic effects (nodal hiPSC-CMs), atrial fibrillation (atrial hiPSC-CMs), or ventricula
Autor:
Benedikt Schrage, Jacob Schön, Elke Hammer, Svenja Warnke, Diana Lindner, Hanna Bräuninger, Uwe Völker, Stefan Blankenberg, Katharina Scherschel, Dirk Westermann, Tilo Thottakara, Paulus Kirchhof, Vishnu M. Dhople, Svenja Voss
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12262, p 12262 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences
Volume 22
Issue 22
Fibroblasts contribute to approximately 20% of the non-cardiomyocytic cells in the heart. They play important roles in the myocardial adaption to stretch, inflammation, and other pathophysiological conditions. Fibroblasts are a major source of extrac
Autor:
Claire Rhee, Qi Gao, Elijah Ejun Huang, Rocky S. Tuan, Michael S. Gold, Hang Lin, Zhenyu Yao, Masahiro Maruyama, Bruce A. Bunnell, Shiqi Xiang, Zhong Li, Stuart B. Goodman
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12837, p 12837 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12837
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12837
Fibroblasts in the synovial membrane secrete molecules essential to forming the extracellular matrix (ECM) and supporting joint homeostasis. While evidence suggests that fibroblasts contribute to the response to joint injury, the outcomes appear to b
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12039, p 12039 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
Purpose: The objective of the current study was to evaluate the effects of the autotaxin (ATX)–lysophosphatidic acid (LPA) signaling axis on the human trabecular meshwork (HTM) in two-dimensional (2D) and three-dimensional (3D) cultures of HTM cell
Autor:
Thao Thi Dang, Sung Hoon Back
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12083, p 12083 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
The autophagy-lysosome pathway is a major protein degradation pathway stimulated by multiple cellular stresses, including nutrient or growth factor deprivation, hypoxia, misfolded proteins, damaged organelles, and intracellular pathogens. Recent stud
Autor:
José Antonio Gabaldón-Hernández, María Isabel Sanchez-Lorencio, Camilo Zamora-Ledezma, Luis Meseguer-Olmo, Iván López-González, Elena Tristante Barrenechea
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11216, p 11216 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences
Volume 22
Issue 20
In this work, we evaluated the influence of a novel hybrid 3D-printed porous composite scaffold based on poly(ε-caprolactone) (PCL) and β-tricalcium phosphate (β-TCP) microparticles in the process of adhesion, proliferation, and osteoblastic diffe