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Autor:
Vito Michele Fazio, Mario Cioce
Publikováno v:
Cancers, Vol 13, Iss 700, p 700 (2021)
Cancers
Cancers (Basel) 13 (2021): 1–23. doi:10.3390/cancers13040700
info:cnr-pdr/source/autori:Cioce M.; Fazio V.M./titolo:Epha2 and egfr: Friends in life, partners in crime. can epha2 be a predictive biomarker of response to anti-egfr agents?/doi:10.3390%2Fcancers13040700/rivista:Cancers (Basel)/anno:2021/pagina_da:1/pagina_a:23/intervallo_pagine:1–23/volume:13
Cancers
Cancers (Basel) 13 (2021): 1–23. doi:10.3390/cancers13040700
info:cnr-pdr/source/autori:Cioce M.; Fazio V.M./titolo:Epha2 and egfr: Friends in life, partners in crime. can epha2 be a predictive biomarker of response to anti-egfr agents?/doi:10.3390%2Fcancers13040700/rivista:Cancers (Basel)/anno:2021/pagina_da:1/pagina_a:23/intervallo_pagine:1–23/volume:13
Simple Summary The Ephrin receptors and their ligands play important roles in organ formation and tissue repair, by orchestrating complex programs of cell adhesion and repulsion, however, this same system plays a role in cancer development In fact, E
Publikováno v:
Cancers, Vol 13, Iss 920, p 920 (2021)
Cancers
Cancers
Simple Summary Natural products have continued to play an important role in new drug discovery with a considerable number of marketed drugs being derived from naturally occurring compounds, particularly in the area of cancer. Taccalonolides are a new
Autor:
Muhammad Fayyaz ur Rehman, Wei Xing Zhang, Humna Ellahi, Nargis Sultana, Muhammad Ilyas Tariq, Fariha Kanwal, Maryam Bashir, Changrui Lu, Muhammad Jamil, Rizwan Ashraf
Publikováno v:
Crystals, Vol 11, Iss 208, p 208 (2021)
Crystals
Volume 11
Issue 2
Crystals
Volume 11
Issue 2
Alzheimer’s disease (AD) causes dementia and continuous damage to brain cells. Cholinesterase inhibitors can alleviate the condition by increasing communication between the nerve cells and reducing the risk of dementia. In an effort to treat Alzhei
Publikováno v:
Pharmaceutics, Vol 13, Iss 314, p 314 (2021)
Pharmaceutics
Volume 13
Issue 3
Pharmaceutics
Volume 13
Issue 3
Organic anion transporter 3 (OAT3) is mainly expressed at the basolateral membrane of kidney proximal tubules, and is involved in the renal elimination of various kinds of important drugs, potentially affecting drug efficacy or toxicity. Our laborato
Autor:
Sasidharan Padmaja Divya, Sandeep Kumar Parvathareddy, Fouad Al-Dayel, Saif S. Al-Sobhi, Poyil Pratheeshkumar, Abdul K. Siraj, Khawla S Al-Kuraya
Publikováno v:
Cancers, Vol 13, Iss 555, p 555 (2021)
Cancers
Volume 13
Issue 3
Cancers
Volume 13
Issue 3
PD-L1 inhibition is a promising therapeutic target whose efficacy has been demonstrated in several cancers. Immunohistochemistry was performed to assess PD-L1 protein expression in PTC. We further conducted in vitro analysis to investigate the role o
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1472, p 1472 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Diseases such as myocardial infarction, ischaemic stroke, peripheral vascular disease and venous thromboembolism are major contributors to morbidity and mortality. Procoagulant, anticoagulant and fibrinolytic pathways are finely regulated in healthy
Autor:
László Csiba, Zsuzsa Bagoly, Rita Angéla Orbán-Kálmándi, Éva Katona, István Szegedi, Ferenc Sarkady, Barbara Barath, Réka Bogáti
Publikováno v:
Biomolecules, Vol 11, Iss 347, p 347 (2021)
Biomolecules
Volume 11
Issue 3
Biomolecules
Volume 11
Issue 3
Cross-linking of α2-plasmin inhibitor (α2-PI) to fibrin by activated factor XIII (FXIIIa) is essential for the inhibition of fibrinolysis. Little is known about the factors modifying α2-PI incorporation into the fibrin clot and whether the extent
Publikováno v:
Marine Drugs, Vol 19, Iss 90, p 90 (2021)
Marine Drugs
Volume 19
Issue 2
Marine Drugs
Volume 19
Issue 2
Using bio-guided fractionation and based on the inhibitory activities of nitric oxide (NO) and prostaglandin E2 (PGE2), eight isoquinolinequinone derivatives (1–8) were isolated from the marine sponge Haliclona sp. Among these, methyl O-demethylren
Publikováno v:
Viruses, Vol 13, Iss 315, p 315 (2021)
Viruses
Volume 13
Issue 2
Viruses
Volume 13
Issue 2
Host response to a viral infection includes the production of type I interferon (IFN) and the induction of interferon-stimulated genes that have broad antiviral effects. One of the key antiviral effectors is the IFN-inducible oligoadenylate synthetas
Autor:
N.C.N. Perera, Stefanie A I Weiss, Oliver Schilling, Salome R. T. Rehm, Martin L Biniossek, Dieter E. Jenne
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1658, p 1658 (2021)
Int. J. Mol. Sci. 22:1658 (2021)
International Journal of Molecular Sciences
Int. J. Mol. Sci. 22:1658 (2021)
International Journal of Molecular Sciences
The deepest evolutionary branches of the trypsin/chymotrypsin family of serine proteases are represented by the digestive enzymes of the gastrointestinal tract and the multi-domain proteases of the blood coagulation and complement system. Similar to