Zobrazeno 1 - 10
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pro vyhledávání: ''
Autor:
Francesca Malerba, Roberto Coccurello, Pietro Calissano, Egidio Stigliano, Bijorn Omar Balzamino, Giuseppina Amadoro, Anna Atlante, Marco Dell'Aquila, Giacomo Giacovazzo, Alessandra Micera, Federico La Regina, Valentina Latina
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12158, p 12158 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22
International journal of molecular sciences
22 (2021): 12158-1–12158-35. doi:10.3390/ijms222212158
info:cnr-pdr/source/autori:Latina V.; Giacovazzo G.; Calissano P.; Atlante A.; La Regina F.; Malerba F.; Dell'aquila M.; Stigliano E.; Balzamino B.O.; Micera A.; Coccurello R.; Amadoro G./titolo:Tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic alzheimer's disease (Sad) mouse model/doi:10.3390%2Fijms222212158/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:12158-1/pagina_a:12158-35/intervallo_pagine:12158-1–12158-35/volume:22
International Journal of Molecular Sciences
Volume 22
Issue 22
International journal of molecular sciences
22 (2021): 12158-1–12158-35. doi:10.3390/ijms222212158
info:cnr-pdr/source/autori:Latina V.; Giacovazzo G.; Calissano P.; Atlante A.; La Regina F.; Malerba F.; Dell'aquila M.; Stigliano E.; Balzamino B.O.; Micera A.; Coccurello R.; Amadoro G./titolo:Tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic alzheimer's disease (Sad) mouse model/doi:10.3390%2Fijms222212158/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:12158-1/pagina_a:12158-35/intervallo_pagine:12158-1–12158-35/volume:22
Tau cleavage plays a crucial role in the onset and progression of Alzheimer’s Disease (AD), a widespread neurodegenerative disease whose incidence is expected to increase in the next years. While genetic and familial forms of AD (fAD) occurring ear
Autor:
Chun Chih Huang, Li Deng, Yi Cheng Chu, Ming Yao Chen, Tung Yao Tsai, Yew Min Tzeng, Chi Tai Yeh, Vijesh Kumar Yadav
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7508, p 7508 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences
Volume 22
Issue 14
The KRAS mutation is one of the leading driver mutations in colorectal cancer (CRC), and it is usually associated with poor prognosis and drug resistance. Therapies targeting the epidermal growth factor receptor (EFGR) are widely used for end-stage C
Autor:
Gayathri Soundarajan, Chinmay K. Mantri, Abhay P. S. Rathore, Sylvie Alonso, Ashley L. St. John, Wilfried A. A. Saron
Publikováno v:
Viruses, Vol 13, Iss 900, p 900 (2021)
Viruses
Volume 13
Issue 5
Viruses
Volume 13
Issue 5
Sub-neutralizing concentrations of antibodies in dengue infected patients is a major risk factor for the development of dengue hemorrhagic fever and dengue shock syndrome. Here, we describe a mouse model with a deficiency in mast cells (MCs) in addit
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 741, p 741 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences
Volume 22
Issue 2
Alzheimer&rsquo
s disease (AD), characterized by cognitive impairments, is considered to be one of the most widespread chronic neurodegenerative diseases worldwide. We recently introduced a novel therapeutic agent for AD treatment, the T-type ca
s disease (AD), characterized by cognitive impairments, is considered to be one of the most widespread chronic neurodegenerative diseases worldwide. We recently introduced a novel therapeutic agent for AD treatment, the T-type ca
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6699, p 6699 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 18
International Journal of Molecular Sciences
Volume 21
Issue 18
Dihydromyricetin (DHY), a flavonoid component isolated from Ampelopsis grossedentata, exerts versatile pharmacological activities. However, the possible effects of DHY on diabetic vascular endothelial dysfunction have not yet been fully elucidated. I
Autor:
Nermin Eissa, Dorota Łażewska, Richard L. Jayaraj, Shreesh Ojha, Petrilla Jayaprakash, Bassem Sadek, Sheikh Azimullah, Holger Stark, Katarzyna Kieć-Kononowicz, David Reiner, Rami Beiram
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3996, p 3996 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 11
International Journal of Molecular Sciences
Volume 21
Issue 11
The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively. The enzyme acetylcholine esterase (AChE) is involved in the metabolism of brain ACh. Both b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3179, p 3179 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 9
International Journal of Molecular Sciences
Volume 21
Issue 9
Severe acute respiratory syndrome&ndash
associated coronavirus (SARS-CoV) initiates the cytokine/chemokine storm-mediated lung injury. The SARS-CoV unique domain (SUD) with three macrodomains (N, M, and C), showing the G-quadruplex binding activ
associated coronavirus (SARS-CoV) initiates the cytokine/chemokine storm-mediated lung injury. The SARS-CoV unique domain (SUD) with three macrodomains (N, M, and C), showing the G-quadruplex binding activ
Autor:
Álvaro Pejenaute, Felipe Prosper, Javier Marqués, Gloria Abizanda, Guillermo Zalba, Eduardo Ansorena, Carlos de Miguel, Juan J. Martinez-Irujo, Adriana Cortés
Publikováno v:
Cells, Vol 9, Iss 3, p 637 (2020)
Cells
Volume 9
Issue 3
Cells
Volume 9
Issue 3
Oxidative stress is a main molecular mechanism that underlies cardiovascular diseases. A close relationship between reactive oxygen species (ROS) derived from NADPH oxidase (NOX) activity and the prostaglandin (PG) biosynthesis pathway has been descr
Publikováno v:
Molecules, Vol 24, Iss 21, p 3993 (2019)
Molecules
Volume 24
Issue 21
Molecules
Volume 24
Issue 21
Administration of subanesthetic doses of ketamine during brain maturation represents a tool to mimic an early insult to the central nervous system (CNS). The cerebellum is a key player in psychosis pathogenesis, to which oxidative stress also contrib
Autor:
Félix Carvalho, Ana Isabel Padrão, Fernando Remião, Maria de Lourdes Bastos, Emília Sousa, Salomé Gonçalves-Monteiro, Margarida Duarte-Araújo, Vera Marisa Costa, Ana Reis-Mendes, José Alberto Duarte
Publikováno v:
Biomolecules, Vol 11, Iss 1725, p 1725 (2021)
Biomolecules; Volume 11; Issue 11; Pages: 1725
Biomolecules
Biomolecules; Volume 11; Issue 11; Pages: 1725
Biomolecules
Doxorubicin (DOX) is a topoisomerase II inhibitor commonly used in the treatment of several types of cancer. Despite its efficacy, DOX can potentially cause fatal adverse effects, like cardiotoxicity. This work aimed to assess the role of inflammatio