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Autor:
Amany O. Mohamed, Mohamed El-Sherbiny, Shymaa E. Bilay, Hoda S. Elmahdi, Afaf T Ibrahiem, Mohamed A. Helal, Ziad E. Hamed, Mona K. Tawfik, Mohamed Ahmed Eladl, Sawsan A. Zaitone, Asma M. Alshahrani, Rehab M. El-Sayed
Publikováno v:
Molecules, Vol 26, Iss 6858, p 6858 (2021)
Molecules
Volume 26
Issue 22
Molecules
Volume 26
Issue 22
Nifuroxazide is an antidiarrheal medication that has promising anticancer activity against diverse types of tumors. The present study tested the anticancer activity of nifuroxazide against Ehrlich’s mammary carcinoma grown in vivo. Furthermore, we
Autor:
Dorota Łażewska, Agata Doroz-Płonka, Szczepan Mogilski, David Reiner-Link, Annika Frank, Barbara Malawska, Holger Stark, Justyna Godyń, Paula Zaręba, Marek Bajda, Maria Kaleta, Agnieszka Olejarz-Maciej, Katarzyna Kieć-Kononowicz, Dorota Stary
Publikováno v:
Molecules, Vol 26, Iss 3580, p 3580 (2021)
Molecules
Volume 26
Issue 12
Molecules
Volume 26
Issue 12
Neurodegenerative diseases, e.g., Alzheimer’s disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but
Autor:
Mong Heng Wang, Shu Hsien Huang, Jing Lun Yen, Fan Li Lin, Chih Kuang Chen, Ping Huei Tsai, Po Jen Hsueh, Che Jen Hsiao, Yueh-Hsiung Kuo, George Hsiao
Publikováno v:
Molecules, Vol 26, Iss 2970, p 2970 (2021)
Molecules
Volume 26
Issue 10
Molecules
Volume 26
Issue 10
Intracerebral hemorrhage (ICH) is a devastating neurological disorder characterized by an exacerbation of neuroinflammation and neuronal injury, for which few effective therapies are available at present. Inhibition of excessive neuroglial activation
Autor:
Luc Vanhamme, Vedaste Kagisha, Jacob Souopgui, Allison Ledoux, Olivia Jansen, Michel Frederich, Raymond Muganga, Jean Claude Didelot Tomani, Alembert T. Tchinda
Publikováno v:
Molecules, Vol 25, Iss 4693, p 4693 (2020)
Molecules, 25 (20
Molecules
Volume 25
Issue 20
Molecules, 25 (20
Molecules
Volume 25
Issue 20
The activation of NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome and/or its components is associated with the physio-pathogenesis of many respiratory diseases including asthma, COPD (chronic obstructive pulmonary disease), SAR
Autor:
Maral Aminpour, Ewa Maj, Witold Mozga, Adam Huczyński, Joanna Wietrzyk, Jack A. Tuszynski, Julia Krzywik
Publikováno v:
Molecules, Vol 25, Iss 3540, p 3540 (2020)
Molecules
Volume 25
Issue 15
Molecules
Volume 25
Issue 15
Colchicine is a well-known anticancer compound showing antimitotic effect on cells. Its high cytotoxic activity against different cancer cell lines has been demonstrated many times. In this paper we report the syntheses and spectroscopic analyses of
Publikováno v:
Molecules, Vol 24, Iss 21, p 3993 (2019)
Molecules
Volume 24
Issue 21
Molecules
Volume 24
Issue 21
Administration of subanesthetic doses of ketamine during brain maturation represents a tool to mimic an early insult to the central nervous system (CNS). The cerebellum is a key player in psychosis pathogenesis, to which oxidative stress also contrib
Publikováno v:
Molecules, Vol 24, Iss 21, p 3907 (2019)
Molecules
Volume 24
Issue 21
Molecules
Volume 24
Issue 21
Trastuzumab is an antibody used for the treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancers. Since trastuzumab is an internalizing antibody, two factors could play an important role in achieving high uptake and
Autor:
Manuela Grimaldi, Maurizio Bifulco, Maria Proto, Verdiana Covelli, Mohammad Firoznezhad, Rosario Randino, Anna Maria D'Ursi, Patrizia Gazzerro, Manuela Rodriquez, Veronica De Simone, Gianluca Matteoli
Publikováno v:
Molecules, Vol 26, Iss 7146, p 7146 (2021)
Molecules; Volume 26; Issue 23; Pages: 7146
Molecules
Molecules; Volume 26; Issue 23; Pages: 7146
Molecules
N6-Isopentenyladenosine (i6A) is a naturally occurring modified nucleoside displaying in vitro and in vivo antiproliferative and pro-apoptotic properties. In our previous studies, including an in silico inverse virtual screening, NMR experiments and
Autor:
S. S. Zykova, Sergei Boichuk, Maria Novikova, A R Galembikova, Pavel Dunaev, Ksenia Gankova, Pavel Kopnin, N. M. Igidov, Firuza Bikinieva, Kirill Syuzov, Aida Aukhadieva
Publikováno v:
Molecules, Vol 26, Iss 5780, p 5780 (2021)
Molecules
Volume 26
Issue 19
Molecules
Volume 26
Issue 19
Microtubule targeting agents (MTAs) that interfere with the dynamic state of the mitotic spindle are well-known and effective chemotherapeutic agents. These agents interrupt the microtubule network via polymerization or depolymerization, halting the
Autor:
Chan-Yen Kuo, Geng-Ruei Chang, Ming-Yang Tsai, Tzu-Chun Lin, Yu-Chen Wang, Huei-Jyuan Liao, Chung-Hung Chen, Wei-Li Lin
Publikováno v:
Molecules
Volume 26
Issue 15
Molecules, Vol 26, Iss 4683, p 4683 (2021)
Volume 26
Issue 15
Molecules, Vol 26, Iss 4683, p 4683 (2021)
Zotarolimus is a semi-synthetic derivative of rapamycin and an inhibitor of mammalian target of rapamycin (mTOR) signaling. Currently, zotarolimus is used to prolong the survival time of organ grafts, but it is also a novel immunosuppressive agent wi