Zobrazeno 1 - 10
of 21
pro vyhledávání: '"11"'
Autor:
Rico Hagelaar, Kirsten Canté-Barrett, Laurent Holtzer, Wim Verhaegh, Valentina Cordo, Anja van de Stolpe, Henk van Ooijen, Jules P.P. Meijerink
Publikováno v:
Cancers, Vol 12, Iss 3142, p 3142 (2020)
Canté-Barrett, K, Holtzer, L, van Ooijen, H, Hagelaar, R, Cordo', V, Verhaegh, W, van de Stolpe, A & Meijerink, J P P 2020, ' A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer ', Cancers, vol. 12, no. 11, 3142, pp. 1-17 . https://doi.org/10.3390/cancers12113142
Cancers
Volume 12
Issue 11
Canté-Barrett, K, Holtzer, L, van Ooijen, H, Hagelaar, R, Cordo', V, Verhaegh, W, van de Stolpe, A & Meijerink, J P P 2020, ' A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer ', Cancers, vol. 12, no. 11, 3142, pp. 1-17 . https://doi.org/10.3390/cancers12113142
Cancers
Volume 12
Issue 11
Simple Summary The Notch signal transduction pathway is important for various physiological processes, including immune responses, and plays a role in many diseases, for example cancer. We have developed a new assay to quantitatively measure Notch pa
Autor:
Cally J Ho, Sharon M. Gorski
Publikováno v:
Cancers, Vol 11, Iss 11, p 1775 (2019)
Cancers
Cancers
Despite advances in diagnostic tools and therapeutic options, treatment resistance remains a challenge for many cancer patients. Recent studies have found evidence that autophagy, a cellular pathway that delivers cytoplasmic components to lysosomes f
Publikováno v:
Cancers, Vol 11, Iss 10, p 1557 (2019)
Cancers
Cancers, vol 11, iss 10
Cancers
Cancers, vol 11, iss 10
One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions. Exosomes play important roles in both normal and patho
Publikováno v:
Cancers, Vol 11, Iss 5, p 726 (2019)
Cancers
Cancers, 11(5)
Cancers
Cancers, 11(5)
The Transforming Growth Factor-β (TGF-β) signaling pathway has a well-documented, context-dependent role in breast cancer development. In normal and premalignant cells, it acts as a tumor suppressor. By contrast, during the malignant phases of brea
Publikováno v:
Cancers, Vol 11, Iss 4, p 437 (2019)
Cancers
Volume 11
Issue 4
Cancers
Volume 11
Issue 4
Epidermal growth factor receptor (EGFR) is the key molecular target for non-small cell lung cancer (NSCLC) due to its major contribution to complex signaling cascades modulating the survival of cancer cells. Targeting EGFR-mediated signaling pathways
Autor:
Giampaolo Tortora, Fotios Loupakis, Maria Alessandra Calegari, Emilio Bria, Matteo Fassan, Maria Bensi, Lisa Salvatore, Brunella Di Stefano
Publikováno v:
Cancers
Cancers, Vol 11, Iss 11, p 1765 (2019)
Cancers, Vol 11, Iss 11, p 1765 (2019)
Molecular assessment of colorectal cancer (CRC) is receiving growing attention, beyond RAS and BRAF, because of its influence on prognosis and prediction in cancer treatment. PTEN (phosphatase and tensin homologue), a tumor suppressor, regulating cel
Publikováno v:
Cancers
Volume 11
Issue 10
Cancers, Vol 11, Iss 10, p 1613 (2019)
Volume 11
Issue 10
Cancers, Vol 11, Iss 10, p 1613 (2019)
The human microRNA 452 (MIR452) was identified as a colorectal cancer (CRC)-associated micro RNA (miRNA) by miRNA expression profiling of human CRC tissues versus normal colorectal tissues. It was significantly up-regulated in human CRC tissues. Howe
Autor:
Haruo Nakayama, Satoshi Fujita, Takatoshi Sakurai, Kazuya Aoki, Ryo Suzuki, Sho Sato, Nozomi Hirai, Satoshi Iwabuchi, Yu Hiramoto, Norihiko Saito, Morito Hayashi
Publikováno v:
Cancers
Volume 11
Issue 10
Cancers, Vol 11, Iss 10, p 1564 (2019)
Volume 11
Issue 10
Cancers, Vol 11, Iss 10, p 1564 (2019)
The Cancer Genome Atlas (TCGA) project described a robust gene expression-based molecular classification of glioblastoma (GBM), but the functional and biological significance of the subclasses has not been determined. The present comprehensive analys
Publikováno v:
Cancers
Volume 11
Issue 1
Cancers, Vol 11, Iss 1, p 9 (2018)
Volume 11
Issue 1
Cancers, Vol 11, Iss 1, p 9 (2018)
The poor prognosis of hepatocellular carcinoma (HCC) is resulted from tumor metastasis. Signaling pathways triggered by deregulated receptor tyrosine kinases (RTKs) were the promising therapeutic targets for prevention of HCC progression. However, RT
Autor:
Jyothi Thundimadathil, Nirmala Mavila
Publikováno v:
Cancers, Vol 11, Iss 10, p 1406 (2019)
Cancers
Cancers
Hepatoblastoma (HB) is the most common form of primary liver malignancy found in pediatric populations. HB is considered to be clonal and arises from hepatoblasts, or embryonic liver progenitor cells. These less differentiated tumor-initiating progen