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Autor:
Saeed Y. Al-ramadan, Fatma J. Al-Saeedi, A. M. Soliman, Gamal M. Bekhet, Maged E. Mohamed, Rebai Ben Ammar, Medhat Ahmed El-Naggar, Peramaiyan Rajendran
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 217, p 217 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
International Journal of Molecular Sciences
Volume 22
Issue 1
In this study, kaempferol (KFL) shows hepatoprotective activity against zearalenone (ZEA)-induced oxidative stress and its underlying mechanisms in in vitro and in vivo models were investigated. Oxidative stress plays a critical role in the pathophys
Publikováno v:
Cells, Vol 10, Iss 3316, p 3316 (2021)
Cells
Cells
The sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylase and ADP-ribosyl transferases plays key roles in aging, metabolism, stress response, and aging-related diseases. SIRT2 is a unique sirtuin that is expressed in the cytosol a
Autor:
Laurie-Anne Lamotte, Lionel Tafforeau
Publikováno v:
Viruses, Vol 13, Iss 2309, p 2309 (2021)
Viruses
Viruses
Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influ
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12066, p 12066 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
Background: Extracellular matrix (ECM)-derived mechanical stimuli regulate many cellular processes and phenotypes through mechanotransduction signaling pathways. Substrate stiffness changes cell phenotypes and promotes angiogenesis, epithelial to mes
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11159, p 11159 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Non-ionizing radiation is commonly used in the clinical setting, despite its known ability to trigger oxidative stress and apoptosis, which can lead to damage and cell death. Although induction of cell death is typically considered harmful, apoptosis
Autor:
Seong Soo Joo, Yeong-Min Yoo
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11341, p 11341 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences
Volume 22
Issue 21
Human amylin or islet amyloid polypeptide (hIAPP) is synthesized in the pancreatic β-cells and has been shown to contribute to the pathogenesis of type 2 diabetes (T2D) in vitro and in vivo. This study compared amylin oligomerization/expression and
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9902, p 9902 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Ferroptosis is a newly recognized type of cell death that is different from traditional forms of cell death, such as apoptosis, autophagy, and necrosis. It is caused by the accumulation of intracellular iron, promoting lipid peroxidation and leading
Autor:
Emmie de Wit, Elizabeth R. Fischer, Sonja M. Best, Paul A. Beare, Brandi N. Williamson, Ted Hackstadt, Cheryl A. Dooley, Abhilash I. Chiramel, Forrest H. Hoyt
Publikováno v:
Viruses, Vol 13, Iss 1798, p 1798 (2021)
Viruses
Volume 13
Issue 9
Viruses
Volume 13
Issue 9
A variety of immunolabeling procedures for both light and electron microscopy were used to examine the cellular origins of the host membranes supporting the SARS-CoV-2 replication complex. The endoplasmic reticulum has long been implicated as a sourc
Autor:
Ronit Vogt Sionov
Publikováno v:
Cells, Vol 10, Iss 2486, p 2486 (2021)
Cells
Cells
Neutrophils are the most abundant immune cell in the circulation of human and act as gatekeepers to discard foreign elements that have entered the body. They are essential in initiating immune responses for eliminating invaders, such as microorganism
Autor:
John F. Hancock, Yong Zhou
Publikováno v:
Biomolecules, Vol 11, Iss 1439, p 1439 (2021)
Biomolecules
Biomolecules
The lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases) are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic activities of RAS have been shown to be difficult. Alternatively, RAS funct