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Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12670, p 12670 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Dihydroartemisinin (DHA), a semi-synthetic derivative of artemisinin, is known to play important roles in inhibiting proliferation rate, inducing apoptosis, as well as hindering the metastasis and invasion of glioma cells, but the underlying mechanis
Publikováno v:
Cells, Vol 10, Iss 1820, p 1820 (2021)
Cells
Volume 10
Issue 7
Cells
Volume 10
Issue 7
Background: Osteopontin (OPN) splice variants are identified as predictors of tumour progression and therapeutic resistance in certain types of solid tumours. However, their roles in gastric cancer (GC) remain poorly characterized. The current study
Autor:
Sanda Iacobas, Dumitru A. Iacobas
Publikováno v:
Cells, Vol 10, Iss 1644, p 1644 (2021)
Cells
Volume 10
Issue 7
Cells
Volume 10
Issue 7
Decades of research identified genomic similarities among prostate cancer patients and proposed general solutions for diagnostic and treatments. However, each human is a dynamic unique with never repeatable transcriptomic topology and no gene therapy
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5382, p 5382 (2021)
International journal of molecular sciences, vol 22, iss 10
International Journal of Molecular Sciences
Volume 22
Issue 10
International journal of molecular sciences, vol 22, iss 10
International Journal of Molecular Sciences
Volume 22
Issue 10
(1) Background: methionine cycle is not only essential for cancer cell proliferation but is also critical for metabolic reprogramming, a cancer hallmark. Hepatic and extrahepatic tissues methionine adenosyltransferases (MATs) are products of two gene
Autor:
Rafał Płoski, Małgorzata Rydzanicz, Tomasz M. Grzywa, Jarosław Wejman, Klaudia Klicka, Paweł Włodarski, Wiktor Paskal, Agnieszka Koppolu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3886, p 3886 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences
Volume 22
Issue 8
Melanoma tumors are the most heterogeneous of all tumor types. Tumor heterogeneity results in difficulties in diagnosis and is a frequent cause of failure in treatment. Novel techniques enable accurate examination of the tumor cells, considering thei
Autor:
Gareth I. Owen, Tomas de Mayo, Enrique Norero, Franz Villarroel-Espindola, Maria Alejandra Alarcon, Alejandro H. Corvalan, Wilda Olivares, Julio D. Amigo, Gonzalo Carrasco-Avino, Marcelo Garrido, Miguel Cordova-Delgado, Natalia Landeros, Matías Muñoz-Medel, Ignacio A. Wichmann, Arnoldo Riquelme
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9472, p 9472 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24
International Journal of Molecular Sciences
Volume 21
Issue 24
Reprimo-like (RPRML) is an uncharacterized member of the Reprimo gene family. Here, we evaluated the role of RPRML and whether its regulation by DNA methylation is a potential non-invasive biomarker of gastric cancer. RPRML expression was evaluated b
Autor:
Yu Kai Su, Chien Min Lin, Jia Wei Lin, Jing Wen Shih, Hao Yu Chuang, Chi Tai Yeh, Iat Hang Fong
Publikováno v:
Cells, Vol 9, Iss 1859, p 1859 (2020)
Cells
Volume 9
Issue 8
Cells
Volume 9
Issue 8
Background: Glioblastoma (GB) is one of the most common (~30%) and lethal cancers of the central nervous system. Although new therapies are emerging, chemoresistance to treatment is one of the major challenges in cancer treatment. Brain cytoplasmic 2
Autor:
Sunhyo Ryu, Mihwa Kim, Minwoo Baek, Won Jae Kim, Subhash C. Chauhan, Joo-Yeon Koo, Yoo-Duk Choi, Chan Choi, Peter I. Song, Andrew Tsin, Sheema Khan, Ji-Yeon Jung
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3586, p 3586 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences
Volume 21
Issue 10
Pancreatic cancer is the worst exocrine gastrointestinal cancer leading to the highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is involved in uncontrolled cell growth. Howeve
Autor:
Asako Doi, Hiroyuki Ariyasu, Hidefumi Inaba, Shinsuke Uraki, Hiroto Furuta, Takashi Akamizu, Shozo Yamada, Naoko Inoshita, Noriaki Fukuhara, Shuhei Morita, Ken Takeshima, Hiroshi Nishioka, Naoyuki Nakao
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2831, p 2831 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 8
International Journal of Molecular Sciences
Volume 21
Issue 8
Mismatch repair genes mutS homologs 6/2 (MSH6/2) expressions are involved in tumor growth and programmed cell death 1 ligand 1 (PD-L1) expression in tumor immunity, but the direct association with pituitary adenomas (PAs) is not well understood. We a
Autor:
Martin Clynes, Ray McDermott, Niall Swan, Justine Meiller, Neil T Conlon, Justin Geoghegan, Gerard McVey, Sandra Roche, Kevin C. Conlon, Ninfa L. Straubinger, Robert M. Straubinger, Michael Moriarty, Robert O'Connor, Jean Murphy, Rozana Abdul Rahman, Fiona O'Neill, Sinead Toomey
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 962 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences
Volume 21
Issue 3
Pancreatic cancer remains among the most lethal cancers worldwide, with poor early detection rates and poor survival rates. Patient-derived xenograft (PDX) models have increasingly been used in preclinical and clinical research of solid cancers to fu