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Autor:
Jerzy Pałka, Sylwia Lewoniewska, Izabela Prokop, Weronika Baszanowska, Katarzyna Bielawska, Ilona Oscilowska, Thi Yen Ly Huynh
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 4641, p 4641 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine 2021 10 (20)
Volume 10
Issue 20
Journal of Clinical Medicine
Journal of Clinical Medicine 2021 10 (20)
Volume 10
Issue 20
Simple Summary PRODH/POX (proline dehydrogenase/proline oxidase) is a mitochondrial enzyme that catalyzes proline degradation generating reactive oxygen species (ROS). Estrogens limit proline availability for PRODH/POX by stimulating collagen biosynt
Autor:
Jarosław D. Kasprzak, Kamila Cygulska, Łukasz Figiel, Małgorzata Wraga, Dariusz Slawek, Marek Dąbrowa
Publikováno v:
Medicina, Vol 57, Iss 706, p 706 (2021)
Medicina
Volume 57
Issue 7
Medicina
Volume 57
Issue 7
Background and Objectives: Resistance to ASA (ASAres) is a multifactorial phenomenon defined as insufficient reduction of platelet reactivity through incomplete inhibition of thromboxane A2 synthesis. The aim is to reassess the prevalence and predict
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7731, p 7731 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Retinoic acid (RA) agents possess anti-tumor activity through their ability to induce cellular differentiation. However, retinoids have not yet been translated into effective systemic treatments for most solid tumors. RA signaling is mediated by the
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5042, p 5042 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Genetic studies in the past decade have improved our understanding of the molecular basis of the BCR-ABL1-negative myeloproliferative neoplasm (MPN) polycythaemia vera (PV). Such breakthroughs include the discovery of the JAK2V617F driver mutation in
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4013, p 4013 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Xenoestrogens (XEs) are substances that imitate endogenous estrogens to affect the physiologic functions of humans or other animals. As endocrine disruptors, they can be either synthetic or natural chemical compounds derived from diet, pesticides, co
Autor:
Mio Yamane, Kazuo Tsubota, Shinji Fukuda, Kazuki Asai, Eisuke Shimizu, Hiroyuki Yazu, Fan Yang, Mamoru Ogawa, Yoko Ogawa, Yutaka Kawakami, Jingliang He, Robert Maximilian Rusch, Shinri Sato
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3745, p 3745 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences
Volume 22
Issue 7
Chronic graft-versus-host disease (cGVHD) is one of the most frequent complications experienced after allogeneic hematopoietic stem cell transplantation. Reportedly, dysbiosis and severe damage to the microbiome are also closely associated with GVHD.
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 515, p 515 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine
The chronic myeloid leukemia (CML) therapeutic landscape has dramatically changed with tyrosine kinase inhibitor (TKI) development, which allows a near-normal life expectancy. However, long-term TKI exposure has been associated with persistent advers
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 593, p 593 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Lung cancer is one of the most common malignant neoplasms. As a result of the disease’s progression, patients may develop metastases to the central nervous system. The prognosis in this location is unfavorable; untreated metastatic lesions may lead
Autor:
Fabrizio Fontana, Roberta M. Moretti, Marina Montagnani Marelli, Monica Marzagalli, Patrizia Limonta, Michela Raimondi
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 9511, p 9511 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Pituitary Gonadotropin-Releasing Hormone receptors (GnRH-R) mediate the activity of the hypothalamic decapeptide GnRH, thus playing a key role in the regulation of the reproductive axis. Early-stage prostate cancer (PCa) is dependent on serum androge
Autor:
Veronika Kubasova, Lucia Csaderova, Rudolf Skubla, Jaromir Pastorek, Veronika Simko, Monika Barathova, P Belvončíková, Katarina Grossmannova
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8760, p 8760 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences
Volume 21
Issue 22
The coexistence of cancer and other concomitant diseases is very frequent and has substantial implications for treatment decisions and outcomes. Beta-blockers, agents that block the beta-adrenergic receptors, have been related also to cancers. In the