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pro vyhledávání: ''
Autor:
Chun Chih Huang, Li Deng, Yi Cheng Chu, Ming Yao Chen, Tung Yao Tsai, Yew Min Tzeng, Chi Tai Yeh, Vijesh Kumar Yadav
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7508, p 7508 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 14
International Journal of Molecular Sciences
Volume 22
Issue 14
The KRAS mutation is one of the leading driver mutations in colorectal cancer (CRC), and it is usually associated with poor prognosis and drug resistance. Therapies targeting the epidermal growth factor receptor (EFGR) are widely used for end-stage C
Autor:
Motoaki Sano, Kohsuke Shirakawa
Publikováno v:
Biomolecules, Vol 11, Iss 1047, p 1047 (2021)
Biomolecules
Biomolecules
Unprecedented advances in secondary prevention have greatly improved the prognosis of cardiovascular diseases (CVDs); however, CVDs remain a leading cause of death globally. These findings suggest the need to reconsider cardiovascular risk and optima
Autor:
Gayathri Soundarajan, Chinmay K. Mantri, Abhay P. S. Rathore, Sylvie Alonso, Ashley L. St. John, Wilfried A. A. Saron
Publikováno v:
Viruses, Vol 13, Iss 900, p 900 (2021)
Viruses
Volume 13
Issue 5
Viruses
Volume 13
Issue 5
Sub-neutralizing concentrations of antibodies in dengue infected patients is a major risk factor for the development of dengue hemorrhagic fever and dengue shock syndrome. Here, we describe a mouse model with a deficiency in mast cells (MCs) in addit
Autor:
Albert Breier, Alexandra Poturnayova, Tomáš Kyca, Zdena Sulova, Anton Misak, Lucia Pavlikova, Viera Bohacova, Mário Šereš
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5504, p 5504 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences
Volume 22
Issue 11
In this paper, we compared the effects of bortezomib on L1210 (S) cells with its effects on P-glycoprotein (P-gp)-positive variant S cells, which expressed P-gp either after selection with vincristine (R cells) or after transfection with a human gene
Autor:
Prathamesh Patil, Thomas C. Caffrey, Michael A. Hollingsworth, Swetha Thiyagarajan, Ayrianne J. Crawford, Stefan Vetter, Estelle Leclerc, Tammi L Neville, Simon Shin, Priyanka Swami, James A. Grunkemeyer, Prakash Radhakrishnan, Kelly A. O'Connell
Publikováno v:
Biomolecules, Vol 11, Iss 526, p 526 (2021)
Biomolecules
Volume 11
Issue 4
Biomolecules
Volume 11
Issue 4
Pancreatic ductal adenocarcinoma (PDAC) remains a very difficult cancer to treat. Recent in vitro and in vivo studies suggest that the activation of the receptor for advanced glycation end products (RAGE) by its ligands stimulates pancreatic cancer c
Autor:
Kyong-Su Park, Madeleine Rådinger, Ganesh Vilas Shelke, Cecilia Lässer, Nasibeh Karimi, Lilit Hovhannisyan, Yasunari Kishino, Jan Lötvall, Shintaro Suzuki
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4718, p 4718 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Studying the proteomes of tissue-derived extracellular vesicles (EVs) can lead to the identification of biomarkers of disease and can provide a better understanding of cell-to-cell communication in both healthy and diseased tissue. The aim of this st
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3705, p 3705 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Poorly soluble environmental antigens, including carbon pollutants, are thought to play a role in the incidence of human sarcoidosis, a chronic inflammatory granulomatous disease of unknown causation. Currently, engineered carbon products such as mul
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 741, p 741 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 2
International Journal of Molecular Sciences
Volume 22
Issue 2
Alzheimer&rsquo
s disease (AD), characterized by cognitive impairments, is considered to be one of the most widespread chronic neurodegenerative diseases worldwide. We recently introduced a novel therapeutic agent for AD treatment, the T-type ca
s disease (AD), characterized by cognitive impairments, is considered to be one of the most widespread chronic neurodegenerative diseases worldwide. We recently introduced a novel therapeutic agent for AD treatment, the T-type ca
Autor:
Hydar Ali, Aetas Amponnawarat, Saptarshi Roy, Chalatip Chompunud Na Ayudhya, Carole A. Oskeritzian
Publikováno v:
Cells, Vol 10, Iss 156, p 156 (2021)
Cells
Cells
Perioperative hypersensitivity (POH) to the neuromuscular blocking drug (NMBD) rocuronium was previously thought to be IgE and mast cell (MC)-mediated. However, the recent seminal observation that rocuronium induces degranulation in murine peritoneal
Autor:
Vlada S. Starinets, Kirill S. Tenkov, Konstantin N. Belosludtsev, Natalia V. Belosludtseva, Mikhail V. Dubinin, Eugeny Yu. Talanov
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8763, p 8763 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences
Volume 21
Issue 22
Duchenne muscular dystrophy (DMD) is a severe hereditary disease caused by a lack of dystrophin, a protein essential for myocyte integrity. Mitochondrial dysfunction is reportedly responsible for DMD. This study examines the effect of glucocorticoid