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Autor:
Marcela Crosara Teixeira, Jana Priscila M Pacífico, Allan Andresson Lima Pereira, Daniel Girardi, Gustavo Dos Santos Fernandes, Fernanda P L Guedes de Amorim
Publikováno v:
Pharmaceuticals, Vol 14, Iss 28, p 28 (2021)
Pharmaceuticals
Pharmaceuticals
Advanced hepatocellular carcinoma is a prevalent and potentially aggressive disease. For more than a decade, treatment with sorafenib has been the only approved therapeutic approach. Moreover, no agent has been proven to prolong survival following th
Autor:
Annalisa Cossu, Duong Thi Bich Thuan, Gianfranco Pintus, Anna Maria Posadino, Roberta Giordo, Angelo Zinellu, Gian Luca Erre
Publikováno v:
Molecules, Vol 26, Iss 4729, p 4729 (2021)
Molecules
Molecules
Endothelial cell injury is an early event in systemic sclerosis (SSc) pathogenesis and several studies indicate oxidative stress as the trigger of SSc-associated vasculopathy. Here, we show that circulating factors present in sera of SSc patients inc
Autor:
Yicheng Huang, Jia Sheng, Alan A. Chen, Sweta Vangaveti, Vibhav A. Valsangkar, Goh Woon Lee, Walid M. Fahssi, Waqas S. Awan
Publikováno v:
Molecules, Vol 26, Iss 4620, p 4620 (2021)
Molecules
Volume 26
Issue 15
Molecules
Volume 26
Issue 15
The thrombin binding aptamer (TBA) is a promising nucleic acid-based anticoagulant. We studied the effects of chemical modifications, such as dendrimer Trebler and NHS carboxy group, on TBA with respect to its structures and thrombin binding affinity
Autor:
Abdu Adem, Sheikh Azimullah, Nagoor Meeran M F, Fakhreya Y Jalal, Rami Beiram, Richard L. Jayaraj, Shreesh Ojha
Publikováno v:
Molecules, Vol 26, Iss 4627, p 4627 (2021)
Molecules
Volume 26
Issue 15
Molecules
Volume 26
Issue 15
Parkinson’s disease is characterized by the loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) and the resultant loss of dopamine in the striatum. Various studies have shown that oxidative stress and neuroinflammation plays a maj
Publikováno v:
Pharmaceuticals, Vol 14, Iss 714, p 714 (2021)
Pharmaceuticals
Pharmaceuticals
The potential neuroprotective capacity of four different sulfated glycans: Botryocladia occidentalis-derived sulfated galactan (BoSG) (MW > 100 kDa), Lytechinus variegatus-derived sulfated fucan (LvSF) (MW~90 kDa), high-molecular weight dextran sulfa
Publikováno v:
Molecules, Vol 26, Iss 4598, p 4598 (2021)
MOLECULES
Molecules
Volume 26
Issue 15
MOLECULES
Molecules
Volume 26
Issue 15
Cefquinome and ceftiofur are β-lactam antibiotics used for the treatment of bacterial infections in swine. Although these antimicrobials are administered intramuscularly, the exposure of the gut microbiota to these cephalosporins is not well describ
Publikováno v:
Pharmaceuticals, Vol 14, Iss 736, p 736 (2021)
Pharmaceuticals
Pharmaceuticals
Due to the lack of an etiologic treatment for SARS-CoV-2 and the difficulties involved in developing new drugs, some drugs already approved for other diseases or with efficacy against SARS and MERS, have been used in patients with COVID-19. This syst
Publikováno v:
Pharmaceuticals, Vol 14, Iss 649, p 649 (2021)
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals
Volume 14
Issue 7
Endometrial hyperplasia (EH) is a common gynecological problem and may progress to carcinoma. Early detection and management of EH are mandatory for the prevention of endometrial cancer. Activation of the renin–angiotensin system and angiotensin II
Autor:
Joana Almeida, Conceição Santos, Maria João Martins, Carina Proença, Helena Oliveira, José Miguel P. Ferreira de Oliveira, Eduarda Fernandes
Publikováno v:
Pharmaceuticals, Vol 14, Iss 640, p 640 (2021)
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals
Volume 14
Issue 7
New agents are demanded to increase the therapeutic options for osteosarcoma (OS). Although OS is the most common bone cancer in children and adolescents, it is considered a rare disorder. Therefore, finding adjuvant drugs has potential to advance th
Precursor-Directed Biosynthesis of Aminofulvenes: New Chalanilines from Endophytic Fungus Chalara sp
Publikováno v:
Molecules, Vol 26, Iss 4418, p 4418 (2021)
Molecules
Volume 26
Issue 15
Molecules
Volume 26
Issue 15
The plant endophyte Chalara sp. is able to biotransform the epigenetic modifier vorinostat to form unique, aniline-containing polyketides named chalanilines. Here, we sought to expand the chemical diversity of chalaniline A-type molecules by changing