Zobrazeno 31 - 40
of 400
pro vyhledávání: ''
Autor:
Daniel Hänggi, Christoph Janiak, Donata Maciaczyk, Silke Neumann, Katharina Koch, Beatriz Giesen, Julia Tsiampali, Jaroslaw Maciaczyk
Publikováno v:
Pharmaceuticals, Vol 13, Iss 378, p 378 (2020)
Pharmaceuticals
Volume 13
Issue 11
Pharmaceuticals
Volume 13
Issue 11
Glioblastoma (GBM) is the most aggressive malignant primary brain tumour in adulthood. Despite strong research efforts current treatment options have a limited impact on glioma stem-like cells (GSCs) which contribute to GBM formation, progression and
Publikováno v:
Pharmaceuticals, Vol 13, Iss 413, p 413 (2020)
Pharmaceuticals
Pharmaceuticals
Non-small cell lung cancer (NSCLC) remains the most prevalent and one of the deadliest cancers worldwide. Despite recent success, there is still an urgent need for new therapeutic strategies. It is also becoming increasingly evident that combinatoria
Autor:
Benjamin Meder, Till Milde, Simay Ayhan, Martin Distel, Johannes Ridinger, Sara Najafi, Heike Peterziel, Jagoda K. Wrobel, Ina Oehme, Charlotte Gatzweiler, Damir Krunic, Olaf Witt, Frank Westermann
Publikováno v:
Pharmaceuticals, Vol 13, Iss 345, p 345 (2020)
Pharmaceuticals
Volume 13
Issue 11
Pharmaceuticals
Volume 13
Issue 11
The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug testing models are urgently needed. Zebrafish are a powerful vertebrate model in preclinic
Publikováno v:
Pharmaceuticals, Vol 13, Iss 347, p 347 (2020)
Pharmaceuticals
Pharmaceuticals
The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and catecholamines. Evidence exists that supports the idea that th
Autor:
Brandon J. Henderson, Skylar Y. Cooper
Publikováno v:
Molecules, Vol 25, Iss 4223, p 4223 (2020)
Molecules
Molecules
Over the past two decades, combustible cigarette smoking has slowly declined by nearly 11% in America; however, the use of electronic cigarettes has increased tremendously, including among adolescents. While nicotine is the main addictive component o
Autor:
Kacper Maksymilian Mil, Mateusz Maciejczyk, Małgorzata Ewa Gryciuk, Cezary Pawlukianiec, Małgorzata Żendzian-Piotrowska, Anna Zalewska
Publikováno v:
Pharmaceuticals, Vol 13, Iss 240, p 240 (2020)
Pharmaceuticals
Volume 13
Issue 9
Pharmaceuticals
Volume 13
Issue 9
Meloxicam is a non-steroidal anti-inflammatory drug, which has a preferential inhibitory effect to cyclooxyganase-2 (COX-2). Although the drug inhibits prostaglandin synthesis, the exact mechanism of meloxicam is still unknown. This is the first stud
Autor:
Thammarat Aree
Publikováno v:
Pharmaceuticals, Vol 13, Iss 278, p 278 (2020)
Pharmaceuticals
Volume 13
Issue 10
Pharmaceuticals
Volume 13
Issue 10
Depression is a global threat. Tricyclic antidepressants (TCAs) are still efficacious in treating depression, albeit with more side effects. Cyclodextrins (CDs) with a suitable nanocavity are potential drug carriers and can enhance the drug bioavaila
Autor:
Réjean Lebel, Dina Sikpa, Martin Lepage, Jérôme Côté, Stephen McManus, Martin Savard, Sylvain Chemtob, Fernand Gobeil, David Fortin, Lisa Whittingstall
Publikováno v:
Pharmaceuticals, Vol 13, Iss 279, p 279 (2020)
Pharmaceuticals
Volume 13
Issue 10
Pharmaceuticals
Volume 13
Issue 10
The blood&ndash
brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB
brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB
Publikováno v:
Pharmaceuticals, Vol 13, Iss 117, p 117 (2020)
Pharmaceuticals
Volume 13
Issue 6
Pharmaceuticals
Volume 13
Issue 6
Recent studies using the genetic partial epilepsy model have demonstrated that hyperfunction of astroglial hemichannels contributes to pathomechanism of epileptic seizure. Therefore, to explore the novel anticonvulsive mechanisms, the present study d
Autor:
Taj Mohammad, Afzal Hussain, Bhaskar Datta, Tabish Rehman, Preeti Gupta, Sonam Roy, Amarjyoti Das Mahapatra, Mohamed F. Alajmi, Imtaiyaz Hassan
Publikováno v:
Pharmaceuticals, Vol 13, Iss 118, p 118 (2020)
Pharmaceuticals
Volume 13
Issue 6
Pharmaceuticals
Volume 13
Issue 6
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics
however, selectivity and potency of fi
however, selectivity and potency of fi