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Autor:
Julio Sotelo, Roxana Magaña-Maldonado, Iannel Reyes-Vidal, Daniel Pérez-Pérez, Elda Georgina Chávez-Cortez
Publikováno v:
Pharmaceuticals, Vol 12, Iss 3, p 130 (2019)
Pharmaceuticals
Pharmaceuticals
Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Currently, treatment is ineffective and the median overall survival is 20.9 months. The poor prognosis of GBM is a consequence of several altered signaling pathways that favor
Autor:
Giuliana Cassinelli, Cinzia Lanzi
Publikováno v:
Molecules, Vol 23, Iss 11, p 2915 (2018)
Molecules
Molecules
Beyond anticoagulation, the therapeutic potential of heparin derivatives and heparan sulfate (HS) mimetics (functionally defined HS mimetics) in oncology is related to their ability to bind and modulate the function of a vast array of HS-binding prot
Autor:
Carmela Mazzoccoli, Gerardo Della Sala, Valeria Costantino, Tiziana Tataranni, Claudia Piccoli, Francesca Agriesti
Publikováno v:
Marine Drugs, Vol 16, Iss 12, p 467 (2018)
Marine Drugs
Marine Drugs
The ubiquitin-proteasome pathway (UPP) is the central protein degradation system in eukaryotic cells, playing a key role in homeostasis maintenance, through proteolysis of regulatory and misfolded (potentially harmful) proteins. As cancer cells produ
Publikováno v:
Marine Drugs, Vol 16, Iss 10, p 361 (2018)
Marine Drugs
Volume 16
Issue 10
Marine Drugs
Volume 16
Issue 10
Triple negative breast cancer (TNBC) is a subtype of breast cancers that currently lacks effective targeted therapy. In this study, we found that aurantoside C (C828), isolated from the marine sponge Manihinea lynbeazleyae collected from Western Aust
Autor:
Pavel Dunaev, A R Galembikova, Pavel Kopnin, Ekaterina Micheeva, Sergei Boichuk, N. V. Khromova, Elena Valeeva, Maria Novikova
Publikováno v:
Molecules, Vol 23, Iss 10, p 2643 (2018)
Molecules
Volume 23
Issue 10
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 10
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Dysregulation of the fibroblast growth factor (FGF)/fibroblast growth factor receptor (FGFR) signaling pathway is frequently observed in multiple human malignancies, and thus, therapeutic strategies targeting FGFs and FGFRs in human cancer are being
Autor:
Cristiana Mollinari, Massimo Fini, Patrizia Russo, Daniela Merlo, Stefano Bonassi, Carlo Tomino, Leonardo Lupacchini, Chiara De Dominicis, Fabrizio Maggi
Publikováno v:
Molecules
Volume 26
Issue 1
Molecules (Basel, Online) 26 (2020). doi:10.3390/molecules26010101
info:cnr-pdr/source/autori:Lupacchini L.; Maggi F.; Tomino C.; De Dominicis C.; Mollinari C.; Fini M.; Bonassi S.; Merlo D.; Russo P./titolo:Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV-2 Infection Severity/doi:10.3390%2Fmolecules26010101/rivista:Molecules (Basel, Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:26
Molecules, Vol 26, Iss 101, p 101 (2021)
Volume 26
Issue 1
Molecules (Basel, Online) 26 (2020). doi:10.3390/molecules26010101
info:cnr-pdr/source/autori:Lupacchini L.; Maggi F.; Tomino C.; De Dominicis C.; Mollinari C.; Fini M.; Bonassi S.; Merlo D.; Russo P./titolo:Nicotine Changes Airway Epithelial Phenotype and May Increase the SARS-COV-2 Infection Severity/doi:10.3390%2Fmolecules26010101/rivista:Molecules (Basel, Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:26
Molecules, Vol 26, Iss 101, p 101 (2021)
(1) Background: Nicotine is implicated in the SARS-COV-2 infection through activation of the &alpha
7-nAChR and over-expression of ACE2. Our objective was to clarify the role of nicotine in SARS-CoV-2 infection exploring its molecular and cellul
7-nAChR and over-expression of ACE2. Our objective was to clarify the role of nicotine in SARS-CoV-2 infection exploring its molecular and cellul
Autor:
Li-li Ji, Kecheng Sun, Yanmei Ding, Shoukai Wang, Wenxiang Huang, Le Zhang, Wenxue Zhang, Chang Liu, Bayaer Tumen, Lei Li
Publikováno v:
Molecules, Vol 23, Iss 8, p 2032 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 8
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 8
Acetaminophen (APAP) is a well-known antipyretic and analgesic drug. However, the accidental or intentional APAP overdose will induce liver injury and even acute liver failure. Astragaloside IV (AS-IV), a bioactive compound isolated from Astragali Ra
Autor:
Masami Suganuma, Keisuke Iida, Pattama Wongsirisin, Anchalee Rawangkan, Yoshihiko Shimizu, Kozue Namiki, Yasuhito Kobayashi, Hirota Fujiki
Publikováno v:
Molecules, Vol 23, Iss 8, p 2071 (2018)
Molecules
Volume 23
Issue 8
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 8
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
The anticancer activity of immune checkpoint inhibitors is attracting attention in various clinical sites. Since green tea catechin has cancer-preventive activity in humans, whether green tea catechin supports the role of immune checkpoint inhibitors
Publikováno v:
Molecules, Vol 23, Iss 6, p 1447 (2018)
Molecules
Volume 23
Issue 6
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 6
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Advanced glycation end products (AGEs) could interact with the receptor for AGE (RAGE) as a sterile danger signal to induce inflammation. 4&prime
methoxyresveratrol (4&prime
MR), a polyphenol derived from Dipterocarpaceae, has not been stud
methoxyresveratrol (4&prime
MR), a polyphenol derived from Dipterocarpaceae, has not been stud
Ursolic Acid Attenuates Atherosclerosis in ApoE−/− Mice: Role of LOX-1 Mediated by ROS/NF-κB Pathway
Publikováno v:
Molecules, Vol 23, Iss 5, p 1101 (2018)
Molecules; Volume 23; Issue 5; Pages: 1101
Molecules; Volume 23; Issue 5; Pages: 1101
Atherosclerosis, a chronic inflammatory disease, is a major contributor to cardiovascular diseases. Ursolic acid (UA) is a phytonutrient with widely biological effects including anti-oxidative, anti-inflammatory, and so on. At present, the effect of