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Publikováno v:
Molecules, Vol 26, Iss 4598, p 4598 (2021)
MOLECULES
Molecules
Volume 26
Issue 15
MOLECULES
Molecules
Volume 26
Issue 15
Cefquinome and ceftiofur are β-lactam antibiotics used for the treatment of bacterial infections in swine. Although these antimicrobials are administered intramuscularly, the exposure of the gut microbiota to these cephalosporins is not well describ
Autor:
Mary J. Meegan, Daniela M. Zisterer, Darren Fayne, Niamh M. O’Boyle, Brendan Twamley, Azizah M. Malebari, Denise Coutinho Endringer, Elisangela Flavia Pimentel, Patrick M. Kelly, Seema M. Nathwani, Sara Noorani, Gloria Ana
Publikováno v:
Pharmaceuticals, Vol 14, Iss 169, p 169 (2021)
Pharmaceuticals
Volume 14
Issue 2
Pharmaceuticals
Volume 14
Issue 2
We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7
Autor:
Yusuf S. Althobaiti
Publikováno v:
Pharmaceuticals, Vol 14, Iss 156, p 156 (2021)
Pharmaceuticals
Volume 14
Issue 2
Pharmaceuticals
Volume 14
Issue 2
Quetiapine, an atypical antipsychotic, is effective in the management of schizophrenia, depression, and anxiety. Although quetiapine overdosage and misuse have been reported, its abuse potential has not been investigated in animals. In this study, th
Autor:
Anna C. Jacobs, Stuart D. Tyner, Emily Engeman, Helen R. Freyberger, Andrey A. Filippov, Brendan W. Corey, Mikeljon P. Nikolich, Yunxiu He, Amanda M. Ward
Publikováno v:
Pharmaceuticals, Vol 14, Iss 184, p 184 (2021)
Pharmaceuticals
Volume 14
Issue 3
Pharmaceuticals
Volume 14
Issue 3
Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a serious health threat. Bacteriophage–antibiotic combination therapy is a promising candidate for combating these infections. A 5-phage P. aeruginosa cocktail, PAM2H, was tested in c
Publikováno v:
Pharmaceuticals, Vol 13, Iss 382, p 382 (2020)
Pharmaceuticals
Volume 13
Issue 11
Pharmaceuticals
Volume 13
Issue 11
Atorvastatin is extensively used to treat hypercholesterolemia. However, the wide interindividual variability observed in response to this drug still needs further elucidation. Nowadays, the biology of long non-coding RNAs (lncRNAs) is better underst
Autor:
Réjean Lebel, Dina Sikpa, Martin Lepage, Jérôme Côté, Stephen McManus, Martin Savard, Sylvain Chemtob, Fernand Gobeil, David Fortin, Lisa Whittingstall
Publikováno v:
Pharmaceuticals, Vol 13, Iss 279, p 279 (2020)
Pharmaceuticals
Volume 13
Issue 10
Pharmaceuticals
Volume 13
Issue 10
The blood&ndash
brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB
brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB
Autor:
Taj Mohammad, Afzal Hussain, Bhaskar Datta, Tabish Rehman, Preeti Gupta, Sonam Roy, Amarjyoti Das Mahapatra, Mohamed F. Alajmi, Imtaiyaz Hassan
Publikováno v:
Pharmaceuticals, Vol 13, Iss 118, p 118 (2020)
Pharmaceuticals
Volume 13
Issue 6
Pharmaceuticals
Volume 13
Issue 6
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics
however, selectivity and potency of fi
however, selectivity and potency of fi
Publikováno v:
Pharmaceuticals, Vol 13, Iss 227, p 227 (2020)
Tuberculosis remains the world’s top infectious killer: it caused a total of 1.5 million deaths and 10 million people fell ill with TB in 2018. Thanks to TB diagnosis and treatment, mortality has been falling in recent years, with an estimated 58 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e2fa98b47e3b97144dc42629bbccc2
http://hdl.handle.net/11573/1462744
http://hdl.handle.net/11573/1462744
Autor:
Younes Smani, Rafael Ayerbe-Algaba, Raquel del Toro, Andrea Miró-Canturri, Manuel Mejías, Jerónimo Pachón
Publikováno v:
idUS: Depósito de Investigación de la Universidad de Sevilla
Universidad de Sevilla (US)
Pharmaceuticals
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Pharmaceuticals, Vol 14, Iss 507, p 507 (2021)
Volume 14
Issue 6
Pages: 507
Universidad de Sevilla (US)
Pharmaceuticals
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC
Pharmaceuticals, Vol 14, Iss 507, p 507 (2021)
Volume 14
Issue 6
Pages: 507
This article belongs to the Collection Old Pharmaceuticals with New Applications.
The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches and/or drugs repurposed to be used as mon
The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches and/or drugs repurposed to be used as mon
Autor:
Emma Best, Tony Walls, Lea-Ann S. Kirkham, Peter Richmond, Janessa Pickering, Mejbah Uddin Bhuiyan, Caitlyn Granland, Nikki Mills, Ruth B. Thornton, Camilla de Gier
Publikováno v:
Vaccines, Vol 7, Iss 1, p 14 (2019)
Vaccines
Volume 7
Issue 1
Vaccines
Volume 7
Issue 1
Otitis media (OM) is a major reason for antibiotic consumption and surgery in children. Nasopharyngeal carriage of otopathogens, Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi), is a prerequisite for development of OM, and incr