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Autor:
Guadalupe Garcia-Tsao
Publikováno v:
New England Journal of Medicine. 384:869-871
Decompensated cirrhosis is defined by the presence of ascites, variceal hemorrhage, hepatic encephalopathy, or a combination of these disorders. A stage of further decompensation occurs with the de...
Autor:
Neil Boudville, Suetonia C. Palmer, Fiona G. Brown, Giles Walters, Richard O. Day, Graham R D Jones, Randall J. Faull, Robert J. Walker, Bettina Douglas, Elaine M. Pascoe, Philip Clarke, Vlado Perkovic, Anushree Tiku, Carmel M. Hawley, Donna Reidlinger, David W. Johnson, Ckd-Fix Study Investigators, Janak de Zoysa, David Harris, Alan Cass, John Kanellis, Sunil V. Badve, Laura Robison, Gopala K. Rangan, Nicola Dalbeth
Publikováno v:
New England Journal of Medicine. 382:2504-2513
Background Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimat...
Autor:
Lucy Smyth, Andrea Mazzetti, Charles D. Pusey, Lorraine Harper, Donna Reidlinger, Gina Gregorini, William F. Clark, Pexivas Investigators Pexivas Investigators, Adeera Levin, Toshiko Ito-Ihara, Chen-Au Peh, Xavier Puéchal, Ulrich Specks, Carmel M. Hawley, Oliver Floßmann, Simon Carette, Alina Casian, Wojciech Szczeklik, Peter A. Merkel, Janak de Zoysa, Nader Khalidi, David Jayne, Samir Mehta, Biljana Brezina, Ron Wald, Michael Walsh, Luis Felipe Flores-Suárez, Carol A. McAlear, L. Guillevin, Louis Girard, Natalie Ives, Wladimir Szpirt, Vladimir Tesar, Elizabeth Broadhurst, Christian Pagnoux, Shouichi Fujimoto
Publikováno v:
Walsh, M, Merkel, P A, Peh, C, Szpirt, W M, Puéchal, X, Fujimoto, S, Hawley, C M, Khalidi, N, Floßmann, O, Wald, R, Girard, L P, Levin, A, Gregorini, G, Harper, L, Clark, W F, Pagnoux, C, Specks, U, Smyth, L, Tesar, V, Ito-ihara, T, De Zoysa, J R, Szczeklik, W, Flores-suárez, L F, Carette, S, Guillevin, L, Pusey, C D, Casian, A L, Brezina, B, Mazzetti, A, Mcalear, C A, Broadhurst, E, Reidlinger, D, Mehta, S, Ives, N & Jayne, D R W 2020, ' Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis ', New England Journal of Medicine, vol. 382, no. 7, pp. 622-631 . https://doi.org/10.1056/NEJMoa1803537
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (7), pp.622-631. ⟨10.1056/NEJMoa1803537⟩
New England Journal of Medicine
New England Journal of Medicine, Massachusetts Medical Society, 2020, 382 (7), pp.622-631. ⟨10.1056/NEJMoa1803537⟩
BACKGROUND More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. METHODS We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two re
Publikováno v:
New England Journal of Medicine. 381:1688-1690
Autor:
Richard J. Farrell
Publikováno v:
New England Journal of Medicine. 381:1279-1281
Ulcerative colitis typically manifests in young adults in their 20s and 30s and can progress from mild asymptomatic rectal inflammation to debilitating extensive colitis resulting in frequent blood...
Autor:
Ellen T. McCarthy, Brad H. Rovin, Sanjeev Sethi, James F. Simon, Patrick E. Gipson, Sean J. Barbour, Paul Brenchley, Lee A. Hebert, John R. Sedor, Fernando C. Fervenza, Jonathan Ashley Jefferson, Nelson Leung, Tingting Li, Michelle Hladunewich, Daniel C Cattran, Lada Beara-Lasic, Pietro A. Canetta, Heather Beanlands, Carmen Avila-Casado, Amy N. Sussman, Stephen B. Erickson, Bruno R. da Costa, Dana V. Rizk, Jay Radhakrishnan, Heather N. Reich, Richard A. Lafayette, Dolly F. Green, Gerald B. Appel, David Philibert, Luis A. Juncos, Nabeel Aslam, Samir V. Parikh, Dominic K. Lee, Lesley F. Thomas, Samuel S. Blumenthal, Debbie S. Gipson, John C. Lieske, Peter Jüni
Publikováno v:
MENTOR Investigators 2019, ' Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy ', The New England Journal of Medicine, vol. 381, no. 1, pp. 36-46 . https://doi.org/10.1056/NEJMoa1814427
BACKGROUND: B-cell anomalies play a role in the pathogenesis of membranous nephropathy. B-cell depletion with rituximab may therefore be noninferior to treatment with cyclosporine for inducing and maintaining a complete or partial remission of protei
Autor:
Andrew A. White, Donald D. Stevenson
Publikováno v:
New England Journal of Medicine. 379:1060-1070
Aspirin-Exacerbated Respiratory Disease About 7% of patients with asthma have mucosal swelling, nasal polyps, and worsening of asthma in response to aspirin and other COX-1 inhibitors. Symptoms may...
Autor:
Jorge Maspero, Guy Brusselle, Parameswaran Nair, Hongjie Zhu, Ariel Teper, Neil M.H. Graham, Asif Khan, Mario Castro, Lawrence Sher, Bolanle Akinlade, Heribert Staudinger, Brian N. Swanson, Gianluca Pirozzi, Christian Antoni, Klaus F. Rabe, Marcella Ruddy, Jingdong Chao, Nikhil Amin, Neil Stahl, Jennifer D. Hamilton, George D. Yancopoulos
Publikováno v:
New England Journal of Medicine. 378:2475-2485
Background Dupilumab is a fully human anti–interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. Its effectiveness in reducing oral glucocorticoid use in patients with severe asthma while maintai
Autor:
Paul L. Martin, Carl H. June, Henrique Bittencourt, Hidefumi Hiramatsu, G.D. Myers, Michael A. Pulsipher, Kapildeb Sen, Kara L. Davis, S. Rives, Michael R. Verneris, Yiyun Zhang, Gregory A. Yanik, David Lebwohl, Shannon L. Maude, Jochen Buechner, Christina Peters, Nicolas Boissel, Adriana Balduzzi, B. De Moerloose, Tanya Taran, Stephan A. Grupp, Krysta Schlis, Karen Thudium Mueller, Peter Bader, Michael Boyer, Mimi Leung, Muna Qayed, André Baruchel, Theodore W. Laetsch, Joerg Krueger, Bruce L. Levine, Patricia A. Wood, Heather E. Stefanski, Eneida R. Nemecek, Francoise Mechinaud
Publikováno v:
NEW ENGLAND JOURNAL OF MEDICINE
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
BACKGROUND: In a single-center phase 1-2a study, the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel produced high rates of complete remission and was associated with serious but mainly reversible toxic effects in children a
Autor:
D. Lynn Loriaux
Publikováno v:
New England Journal of Medicine. 376:1451-1459
Only three biochemical tests — urinary free cortisol, plasma corticotropin, and plasma cortisol measurements — are needed to distinguish patients with Cushing’s syndrome from those with obesity or the metabolic syndrome.