Zobrazeno 91 - 100
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Autor:
Bernard S. Goffe, Robert Matheson, Alice B. Gottlieb, Craig L. Leonardi, Ralph Zitnik, Jerold Powers, Andrea Wang
Publikováno v:
New England Journal of Medicine. 349:2014-2022
Inflammatory cytokines such as tumor necrosis factor (TNF) have been implicated in the pathogenesis of psoriasis. We evaluated the safety and efficacy of etanercept, a TNF antagonist, for the treatment of plaque psoriasis.In this 24-week, double-blin
Autor:
Enric Pedrol, M Riera, Manuel Javaloyas, Cristóbal Richart, Pere Domingo, David Dalmau, Ana Cruceta, Elisa de Lazzari, J.A. Arnaiz, Cristina Cortes, Jose M. Gatell, Hernando Knobel, Esteban Ribera, Esteban Martínez, Daniel Podzamczer, Miquel Aranda, Lluís Force, Josep M. Llibre, Ferran Segura
Publikováno v:
New England Journal of Medicine. 349:1036-1046
We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) in whom virologic suppression had been achieved.We randomly assigned 460 adults
Autor:
Dixie Lee Esseltine, Steven Limentani, Robert Z. Orlowski, Seema Singhal, Teru Hideshima, D. Irwin, James R. Berenson, Melissa Alsina, David P. Schenkein, David S. Siegel, Stephanie J. Lee, Paul G. Richardson, Michael Kauffman, S. Vincent Rajkumar, Sundar Jagannath, Kenneth C. Anderson, Gordan Srkalovic, Raymond Alexanian, Julian Adams, David J. Kuter, Bart Barlogie
Publikováno v:
New England Journal of Medicine. 348:2609-2617
BACKGROUND Bortezomib, a boronic acid dipeptide, is a novel proteasome inhibitor that has been shown in preclinical and phase 1 studies to have antimyeloma activity. METHODS In this multicenter, open-label, nonrandomized, phase 2 trial, we enrolled 2
Autor:
Marjan Huizing, Monique B. Perry, Diana L. Fitzpatrick, Mark D. Murphey, Lynn H. Gerber, Wendy J. Introne, Isa Bernardini, Paul D. Anderson, William A. Gahl, Chanika Phornphutkul, Yair Anikster
Publikováno v:
New England Journal of Medicine. 347:2111-2121
Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There is no effective therapy for this disor
Autor:
Alan B. Sandler, Junming Zhu, James E. Krook, David P. Harrington, David H. Johnson, Joan H. Schiller, Corey J. Langer, Chandra P. Belani
Publikováno v:
New England Journal of Medicine. 346:92-98
We conducted a randomized study to determine whether any of three chemotherapy regimens was superior to cisplatin and paclitaxel in patients with advanced non-small-cell lung cancer.A total of 1207 patients with advanced non-small-cell lung cancer we
Autor:
B. Greg Brown, Xue-Qiao Zhao, Alan Chait, Lloyd D. Fisher, Marian C. Cheung, Josh S. Morse, Alice A. Dowdy, Emily K. Marino, Edward L. Bolson, Petar Alaupovic, Jiri Frohlich, Leny Serafini, Ellen Huss-Frechette, Shari Wang, Debbie DeAngelis, Arthur Dodek, John J. Albers
Publikováno v:
New England Journal of Medicine. 345:1583-1592
Both lipid-modifying therapy and antioxidant vitamins are thought to have benefit in patients with coronary disease. We studied simvastatin-niacin and antioxidant-vitamin therapy, alone and together, for cardiovascular protection in patients with cor
Autor:
Salim Yusuf, Gianni Tognoni, Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators, Susan Chrolavicius, Shamir R. Mehta, K K Fox, Zhao F
Publikováno v:
New England Journal of Medicine. 345:494-502
Background: Despite current treatments, patients who have acute coronary syndromes without ST-segment elevation have high rates of major vascular events. We evaluated the efficacy and safety of the antiplatelet agent clopidogrel when given with aspir
Autor:
Vera H. Price
Publikováno v:
New England Journal of Medicine. 341:964-973
Hair loss is a common and distressing symptom. With the approval of two drugs that promote hair growth — finasteride and minoxidil — we can now treat patients with some types of hair loss. Both drugs influence the hair-growth cycle and increase t
Autor:
Andrew J. Martin, J. Loughhead, J. England, Malcolm J. West, E. Breed, Graeme J. Hankey, Petra Meier, N. Bunyan, Lawrence J. Beilin, S. Simes, P. Alyward, B. Dwyer, J. Allen, D. Hunt, K. Hellestrand, Rory Collins, S. Mulray, N. Sharpe, T. Campbell, D. Calvert, G. Pinna, J. Morrison, Julie Jane Yallop, M. Arulchelvam, J. Joughin, S. Netting, H. Lundie-Jenkin, M. Hobbs, M. O'Neill, Andrew Tonkin, H. Willimott, J. Shaw, J. Hanna, Anthony C Keech, V. Sazhin, A. Claque, J. Leach, C. Onuma, S. Ryerson, Allan J. McLean, Sue Caleo, David Colquhoun, M. Shepard, N. Cunio, D. Smithers, S. Chup, P. Thompson, R. J. Simes, S. D'Arcy, Philip J. Barter, Alexis A. Thompson, P. Wallace, N. Cuthbert, D. Newel, H. McKee, I. Beinart, C. Friend, John D.G. Watson, Jane Hall, H. Pater, M. Gandy, Lucy A. Coupland, B. Cuthbert, K. Boss, R. Philip, Wendy Hague, P. Harris, Greg Fulcher, R. Abraham, P. Magnus, Richard Walsh, A. Nguyen, H. White, A. Leach, J. Seabrook, S. Grant, Stephen MacMahon, John Daly, D. McGill, B. Conway, Leonard Kritharides, M. Kava, J. Crowe, John J McNeil, M. Mackie, M. Neaverson, D. Condon-Paoloni, M. Lee, D. Rattos, F. Bates, D. Brown, J. Baker, N. Anderson, P. Nestel, Paul Glasziou, G. Nelson, Patricia M. Davidson, F. O'Reilly, David R. Sullivan
Publikováno v:
New England Journal of Medicine. 339:1349-1357
In patients with coronary heart disease and a broad range of cholesterol levels, cholesterol-lowering therapy reduces the risk of coronary events, but the effects on mortality from coronary heart disease and overall mortality have remained uncertain.
Publikováno v:
New England Journal of Medicine. 339:1285-1292
Angiotensin-converting-enzyme (ACE) inhibitors not only decrease the production of angiotensin II but also decrease the degradation of bradykinin. In this study, a specific bradykinin-receptor antagonist, icatibant acetate (HOE 140), was used to dete