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Publikováno v:
New England Journal of Medicine. 342:1622-1626
The cardiovascular effects of sildenafil are important because of the frequent presence of underlying cardiac disease in men with erectile dysfunction and reports indicating serious cardiac events temporally associated with the use of this drug.We as
Autor:
Dionisio Gonzalez, Guy Storme, Jacques Bernier, Laurence Collette, Thierry Gil, René-Olivier Mirimanoff, Marianne Pierart, Cora N. Sternberg, Michel Bolla, Jean Bernard Dubois, Padraig Warde, Abraham Kuten
Publikováno v:
The New England journal of medicine, 337, 295-300. Massachussetts Medical Society
We conducted a randomized, prospective trial comparing external irradiation with external irradiation plus goserelin (an agonist analogue of gonadotropin-releasing hormone that reduces testosterone secretion) in patients with locally advanced prostat
Autor:
Ted Koster, Pieter H. Reitsma, Gerard M. J. Bos, Jan P. Vandenbroucke, M. den Heijer, Frits R. Rosendaal, Ernest Briët, Henk J. Blom
Publikováno v:
The New England Journal of Medicine, 334, pp. 759-762
The New England Journal of Medicine, 334, 12, pp. 759-762
The New England Journal of Medicine, 334, 759-762
The New England Journal of Medicine, 334, 12, pp. 759-762
The New England Journal of Medicine, 334, 759-762
Previous studies have suggested that hyperhomocysteinemia may be a risk factor for venous thrombosis. To assess the risk of venous thrombosis associated with hyperhomocysteinemia, we studied plasma homocysteine levels in patients with a first episode
Autor:
Adel Giaid, Dina Saleh
Publikováno v:
New England Journal of Medicine. 333:214-221
Pulmonary hypertension is characterized by abnormal thickening of the pulmonary arteries and increased pulmonary vascular resistance. Nitric oxide is a potent endothelium-derived vasorelaxant substance and an inhibitor of smooth-muscle-cell growth. N
Publikováno v:
New England Journal of Medicine, vol. 332, no. 26, pp. 1733-7
BACKGROUND. Alcohol consumption is associated with an increased incidence of hypertension and stroke, but the triggering mechanisms are unclear. In animals, alcohol causes activation of the sympathetic nervous system and also stimulates the release o
Autor:
Lloyd Paul Aiello, Robert L. Avery, Paul G. Arrigg, Bruce A. Keyt, Henry D. Jampel, Sabera T. Shah, Louis R. Pasquale, Hagen Thieme, Mami A. Iwamoto, John E. Park, Hung V. Nguyen, Lloyd M. Aiello, Napoleone Ferrara, George L. King
Publikováno v:
New England Journal of Medicine. 331:1480-1487
Retinal ischemia induces intraocular neovascularization, which often leads to glaucoma, vitreous hemorrhage, and retinal detachment, presumably by stimulating the release of angiogenic molecules. Vascular endothelial growth factor (VEGF) is an endoth
Publikováno v:
New England Journal of Medicine. 331:358-363
The safety of long-term immunosuppression with cyclosporine in renal-transplant recipients is not well understood. This drug may cause a progressive toxic nephropathy, but it also preserves renal function because it prevents rejection. To determine t
Publikováno v:
New England Journal of Medicine. 330:1036-1040
Previous studies suggest that vascular endothelial function may be impaired in essential hypertension. Although muscarinic agonists dilate blood vessels by releasing an endothelium-derived relaxing factor closely related to nitric oxide, nitroprussid
Publikováno v:
New England Journal of Medicine. 328:399-405
The adult respiratory distress syndrome is characterized by pulmonary hypertension and right-to-left shunting of venous blood. We investigated whether inhaling nitric oxide gas would cause selective vasodilation of ventilated lung regions, thereby re
Autor:
Nima Sharifi
Publikováno v:
Asian Journal of Andrology
Recent reports and discussions of preclinical prostate cancer models have emphasized the possibility that enzalutamide resistance may be mediated by glucocorticoid receptors (GR).12 In both in vitro and xenograft animal studies, it is possible to sho