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Autor:
Virginia Rauh
Publikováno v:
New England Journal of Medicine. 378:1171-1174
Polluting Developing Brains When the Environmental Protection Agency scrapped a plan to ban chlorpyrifos, it violated its duty to protect human health, ignoring child health policy that requires all national public health standards to address the spe
Autor:
M Elena Mateos, Michael J. Sullivan, Gareth J. Veal, Piotr Czauderna, Eiso Hiyama, Michael Capra, Kaukab Rajput, Catherine Rechnitzer, Edward A. Neuwelt, Arun Rangaswami, Milind Ronghe, Jane Skeen, Laurence Brugières, Rudolf Maibach, Marc Ansari, Anna Covezzoli, Patrizia Dall'Igna, Penelope Brock, Margaret Childs, Benedicte Brichard, Giorgio Perilongo, Bruce Morland, Derek J. Roebuck, Véronique Laithier
Publikováno v:
The New England journal of medicine, Vol. 378, no.25, p. 2376-2385 (2018)
N Engl J Med
New England Journal of Medicine, Vol. 378, No 25 (2018) pp. 2376-2385
N Engl J Med
New England Journal of Medicine, Vol. 378, No 25 (2018) pp. 2376-2385
BACKGROUND: Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable and irreversible hearing loss. This trial compared cisplatin with cisplatin plus delayed administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948bb74e3d22b6d4d0b5bb2934618063
https://hdl.handle.net/2078.1/235435
https://hdl.handle.net/2078.1/235435
Autor:
Anne Chew, David M. Barrett, Yolanda D. Mahnke, Bruce L. Levine, Noelle Frey, David L. Porter, Pamela A. Shaw, J. Joseph Melenhorst, Carl H. June, Zhaohui Zheng, Susan R. Rheingold, Nancy Bunin, Shannon L. Maude, Vanessa E. Gonzalez, David T. Teachey, Stephan A. Grupp, Simon F. Lacey, Angela Shen, Richard Aplenc
Publikováno v:
New England Journal of Medicine. 371:1507-1517
Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission
Autor:
Amanda Balish, Carolyn B. Bridges, Craig Conover, Bo Shu, Larisa V. Gubareva, Karen Martin, Susan Vagasky, Forrest Smith, Xiyan Xu, Joseph S. Bresee, Stephen Lindstrom, Alexander Klimov, Lyn Finelli, Meghan L. Harris, Vivek Shinde, Deborah Dufficy, Susan I. Gerber, Patricia Quinlisk, Kathy Ritger, Varough M. Deyde, Rebecca Garten, Neal Pascoe, Timothy M. Uyeki
Publikováno v:
New England Journal of Medicine. 360:2616-2625
Triple-reassortant swine influenza A (H1) viruses--containing genes from avian, human, and swine influenza viruses--emerged and became enzootic among pig herds in North America during the late 1990s.We report the clinical features of the first 11 spo
Autor:
John F. Bohnsack, John R. Medich, Melissa J. McIlraith, Steven N. Goodman, Alberto Martini, Ivan Foeldvari, Richard Mouy, Valeria Gerloni, L. Wagner Weiner, Andreas Reiff, Kirsten Minden, Christy Sandborg, Richard K. Vehe, Dana Nemcova, Nicolino Ruperto, Lawrence Jung, Hans Iko Huppertz, Katerina Jarosova, Edward H. Giannini, Nancy Y. Olson, Roberto Carcereri-De-Prati, Dirk Elewaut, Gerd Horneff, Daniel J. Lovell, Jozef Rovensky
Publikováno v:
New England Journal of Medicine. 359:810-820
Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF antibody, in children with polyarticular-course juvenile rheumatoid arthritis.Pa
Autor:
Susan A. Berry, Gerard T. Berry, William J. Rhead, Gregory M. Enns, Saul W. Brusilow, Ada Hamosh
Publikováno v:
New England Journal of Medicine. 356:2282-2292
The combination of intravenous sodium phenylacetate and sodium benzoate has been shown to lower plasma ammonium levels and improve survival in small cohorts of patients with historically lethal urea-cycle enzyme defects.We report the results of a 25-
Autor:
Marjan Huizing, Monique B. Perry, Diana L. Fitzpatrick, Mark D. Murphey, Lynn H. Gerber, Wendy J. Introne, Isa Bernardini, Paul D. Anderson, William A. Gahl, Chanika Phornphutkul, Yair Anikster
Publikováno v:
New England Journal of Medicine. 347:2111-2121
Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There is no effective therapy for this disor
Publikováno v:
New England Journal of Medicine. 329:536-541
It has been hypothesized that a high dietary intake of nitrosamines and their precursors, nitrites and nitrates, is a risk factor for brain tumors. Vitamins C and E inhibit the formation of nitrosamines and thus may be protective.We conducted a case-
Publikováno v:
New England Journal of Medicine. 329:241-245
Myophosphorylase deficiency (McArdle's disease) is one of the most common causes of exercise intolerance, muscle cramps, and recurrent myoglobinuria. The myophosphorylase gene has been sequenced and assigned to chromosome 11, but the molecular basis
Publikováno v:
New England Journal of Medicine. 327:755-759
Deposition of fibrin in glomeruli and renal failure are characteristic features of the hemolytic uremic syndrome. An inhibitor of glomerular fibrinolysis has been detected in plasma from children with this disorder. In this study, we define the inhib