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Autor:
Anne Chew, David M. Barrett, Yolanda D. Mahnke, Bruce L. Levine, Noelle Frey, David L. Porter, Pamela A. Shaw, J. Joseph Melenhorst, Carl H. June, Zhaohui Zheng, Susan R. Rheingold, Nancy Bunin, Shannon L. Maude, Vanessa E. Gonzalez, David T. Teachey, Stephan A. Grupp, Simon F. Lacey, Angela Shen, Richard Aplenc
Publikováno v:
New England Journal of Medicine. 371:1507-1517
Relapsed acute lymphoblastic leukemia (ALL) is difficult to treat despite the availability of aggressive therapies. Chimeric antigen receptor-modified T cells targeting CD19 may overcome many limitations of conventional therapies and induce remission
Autor:
Amanda Balish, Carolyn B. Bridges, Craig Conover, Bo Shu, Larisa V. Gubareva, Karen Martin, Susan Vagasky, Forrest Smith, Xiyan Xu, Joseph S. Bresee, Stephen Lindstrom, Alexander Klimov, Lyn Finelli, Meghan L. Harris, Vivek Shinde, Deborah Dufficy, Susan I. Gerber, Patricia Quinlisk, Kathy Ritger, Varough M. Deyde, Rebecca Garten, Neal Pascoe, Timothy M. Uyeki
Publikováno v:
New England Journal of Medicine. 360:2616-2625
Triple-reassortant swine influenza A (H1) viruses--containing genes from avian, human, and swine influenza viruses--emerged and became enzootic among pig herds in North America during the late 1990s.We report the clinical features of the first 11 spo
Autor:
Marjan Huizing, Monique B. Perry, Diana L. Fitzpatrick, Mark D. Murphey, Lynn H. Gerber, Wendy J. Introne, Isa Bernardini, Paul D. Anderson, William A. Gahl, Chanika Phornphutkul, Yair Anikster
Publikováno v:
New England Journal of Medicine. 347:2111-2121
Alkaptonuria, caused by mutations in the HGO gene and a deficiency of homogentisate 1,2-dioxygenase, results in an accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue. There is no effective therapy for this disor
Publikováno v:
New England Journal of Medicine. 329:241-245
Myophosphorylase deficiency (McArdle's disease) is one of the most common causes of exercise intolerance, muscle cramps, and recurrent myoglobinuria. The myophosphorylase gene has been sequenced and assigned to chromosome 11, but the molecular basis
Publikováno v:
New England Journal of Medicine. 291:164-167
Activated prothrombin concentrate, a complex containing prothrombin, factors VII, IX, X, and XI, was used successfully for the treatment of hemorrhagic episodes in eight patients with factor VIII inhibitors. Six had hemophilia A, and two were women w
Autor:
Steven B. Heymsfield, John R. Darsee
Publikováno v:
New England Journal of Medicine. 304:129-135
In a 46-member kindred with consanguineous ancestry, eight progeny in two generations had congestive cardiomyopathy and markedly elevated urinary taurine levels (range, 411 to 536 mg per gram of creatinine [normal +/- S.D., 89 +/- 32]). Ten other fam
Publikováno v:
New England Journal of Medicine. 297:461-464
To determine the usefulness of terminal deoxynucleotidyl transferase enzyme activity as a biochemical marker in the study of lymphoma, we assayed 50 various malignant lymphomas as well as normal lymphoid tissue for this activity. Neoplastic cells fro
Publikováno v:
New England Journal of Medicine. 293:945-949
Because photodynamic inactivation of herpes simplex virus infections may not be free of hazard, the efficacy of photodynamic inactivation with neutral red and light was evaluated in a placebo-controlled study of 170 episodes of recurrent herpes simpl
Publikováno v:
New England Journal of Medicine. 310:148-154
Using a retrospective analysis we compared 79 recipients of cadaveric renal allografts who were treated with cyclosporine as the sole initial immunosuppressant and 29 concurrent transplant recipients treated with conventional immunosuppressants. The
Publikováno v:
New England Journal of Medicine. 278:1253-1260
Homogenates of small-Intestine mucosa obtained from members of a family with hypophosphatasia were assayed for alkaline phosphatase activity with four phosphate esters. The results were co...