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Publikováno v:
New England Journal of Medicine. 354:832-840
Background The treatment of patients with functional dyspepsia remains unsatisfactory. We assessed the efficacy of itopride, a dopamine D2 antagonist with acetylcholinesterase effects, in patients with functional dyspepsia. Methods Patients with func
Autor:
Biao Lu, John J. Toole, Andrew K. Cheng, Joel E. Gallant, Rafael Campo, Steven L. Chuck, Anton Pozniak, Brian Gazzard, Jeffrey Enejosa, Edwin DeJesus, Jose R. Arribas, Damian J McColl
Publikováno v:
New England Journal of Medicine. 354:251-260
background Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well-tolerated antiretroviral regimens to which patients can easily adhere. methods We conducted an open-label, noninferiority study
Autor:
Barbara R. Rose, Michael D. Robinson, Mark R. Elkins, Carmel Moriarty, Guy B. Marks, Peter T. P. Bye, Colin Harbour, Elena G. Belousova, Wei Xuan
Publikováno v:
New England Journal of Medicine. 354:229-240
Inhaled hypertonic saline acutely increases mucociliary clearance and, in short-term trials, improves lung function in people with cystic fibrosis. We tested the safety and efficacy of inhaled hypertonic saline in a long-term trial.In this double-bli
Autor:
Zheng Rong Liu, Xun Zhang, Guo Hua Zhang, Fan Fan Hou, Di Xie, Ren Wen Geng, Jian Ping Jiang, Guo Bao Wang, Min Liang, Weiru Zhang, Ping Yan Chen
Publikováno v:
New England Journal of Medicine. 354:131-140
Angiotensin-converting-enzyme inhibitors provide renal protection in patients with mild-to-moderate renal insufficiency (serum creatinine level, 3.0 mg per deciliter or less). We assessed the efficacy and safety of benazepril in patients without diab
Autor:
Shashikant Lele, Rebecca N. Baergen, Larry J. Copeland, Helen Q. Huang, Lari Winzel, Deborah K. Armstrong, Brian N. Bundy, Robert A. Burger, Joan L. Walker
Publikováno v:
New England Journal of Medicine. 354:34-43
This randomized, phase III trial by the Gynecologic Oncology Group (GOG) was designed to compare treatment with intravenous paclitaxel plus cisplatin with intravenous paclitaxel plus intraperitoneal cisplatin and paclitaxel in patients with stage III
Publikováno v:
New England Journal of Medicine. 353:2121-2134
background Rimonabant, a selective cannabinoid-1 receptor (CB 1 ) blocker, has been shown to reduce body weight and improve cardiovascular risk factors in obese patients. The Rimonabant in Obesity–Lipids (RIO-Lipids) study examined the effects of r
Autor:
Victor G. Vogel, Vera J. Suman, Greg Yothers, Edward H. Romond, Robert B. Jenkins, John Bryant, Eleftherios P. Mamounas, S. R. Dakhil, Sandra M. Swain, Edith A. Perez, Thomas M. Pisansky, Peter A. Kaufman, Wilma L. Lingle, James N. Ingle, Charles E. Geyer, Silvana Martino, Leila A. Kutteh, Louis Fehrenbacher, Daniel W. Visscher, Nancy E. Davidson, Elizabeth Tan-Chiu, Pamela M. Klein, Norman Wolmark, Soonmyung Paik, Ann M. Brown
Publikováno v:
New England Journal of Medicine. 353:1673-1684
We present the combined results of two trials that compared adjuvant chemotherapy with or without concurrent trastuzumab in women with surgically removed HER2-positive breast cancer.The National Surgical Adjuvant Breast and Bowel Project trial B-31 c
Autor:
Thomas Roth, Charles A. Czeisler, James K. Walsh, Kenneth P. Wright, Jonathan R L Schwartz, Lilliam Kingsbury, Sanjay Arora, Rod J Hughes, David F. Dinges, Gwendolyn E Niebler
Publikováno v:
New England Journal of Medicine. 353:476-486
background Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder.
Publikováno v:
New England Journal of Medicine. 353:375-381
We describe the clinical course of a patient with multiple sclerosis in whom progressive multifocal leukoencephalopathy (PML), an opportunistic viral infection of the central nervous system, developed during treatment with interferon beta-1a and a se
Autor:
Atul K. Bhan, Marion G. Peters, Janet Andersen, Dodi Colquhoun, Tun Liu, Kenneth E. Sherman, Margaret James Koziel, Gregory K. Robbins, Charles van der Horst, Tom Nevin, Beverly Alston, George Harb, Paul A. Volberding, Raymond T. Chung
Publikováno v:
New England Journal of Medicine. 351:451-459
Chronic hepatitis C virus (HCV) infection is a cause of major complications in persons who are also infected with the human immunodeficiency virus (HIV). However, the treatment of HCV infection in such persons has been associated with a high rate of