Zobrazeno 1 - 10
of 51
pro vyhledávání: '"35"'
Autor:
Zachary J. Ward, Catherine M. Giles, Steven L. Gortmaker, Stephen C Resch, Angie L. Cradock, Michael W. Long
Publikováno v:
N Engl J Med
Although the current obesity epidemic has been well documented in children and adults, less is known about long-term risks of adult obesity for a given child at his or her present age and weight. We developed a simulation model to estimate the risk o
Autor:
Helen J, Lachmann, Isabelle, Kone-Paut, Jasmin B, Kuemmerle-Deschner, Kieron S, Leslie, Eric, Hachulla, Pierre, Quartier, Xavier, Gitton, Albert, Widmer, Neha, Patel, Philip N, Hawkins, J, Smith
Publikováno v:
New England Journal of Medicine. 360:2416-2425
The cryopyrin-associated periodic syndrome (CAPS) is a rare inherited inflammatory disease associated with overproduction of interleukin-1. Canakinumab is a human anti-interleukin-1beta monoclonal antibody.We performed a three-part, 48-week, double-b
Autor:
Mikael Pihl, Johnny Ludvigsson, Rosaura Casas, Maria Faresjö, Agne Lindh, Sten A. Ivarsson, Jan Åman, Peter Zerhouni, Stina Axelsson, Nils-Östen Nilsson, Gun Forsander, Eva Örtqvist, Outi Vaarala, Calle Johansson, Mikael Chéramy, Maria Hjorth
Publikováno v:
New England Journal of Medicine. 359:1909-1920
Background The 65-kD isoform of glutamic acid decarboxylase (GAD) is a major autoantigen in patients with type 1 diabetes mellitus. This trial assessed the ability of alum-formulated GAD (GAD-alum) to reverse recent-onset type 1 diabetes in patients
Autor:
Shabir A, Madhi, Vicky, Baillie, Clare L, Cutland, Merryn, Voysey, Anthonet L, Koen, Lee, Fairlie, Sherman D, Padayachee, Keertan, Dheda, Shaun L, Barnabas, Qasim E, Bhorat, Carmen, Briner, Gaurav, Kwatra, Khatija, Ahmed, Parvinder, Aley, Sutika, Bhikha, Jinal N, Bhiman, As'ad E, Bhorat, Jeanine, du Plessis, Aliasgar, Esmail, Marisa, Groenewald, Elizea, Horne, Shi-Hsia, Hwa, Aylin, Jose, Teresa, Lambe, Matt, Laubscher, Mookho, Malahleha, Masebole, Masenya, Mduduzi, Masilela, Shakeel, McKenzie, Kgaogelo, Molapo, Andrew, Moultrie, Suzette, Oelofse, Faeezah, Patel, Sureshnee, Pillay, Sarah, Rhead, Hylton, Rodel, Lindie, Rossouw, Carol, Taoushanis, Houriiyah, Tegally, Asha, Thombrayil, Samuel, van Eck, Constantinos K, Wibmer, Nicholas M, Durham, Elizabeth J, Kelly, Tonya L, Villafana, Sarah, Gilbert, Andrew J, Pollard, Tulio, de Oliveira, Penny L, Moore, Alex, Sigal, Alane, Izu, Peter, Zuidewind
Publikováno v:
The New England Journal of Medicine : NEJM / Publ. by the Massachusetts Medical Society
Background Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV
Autor:
William D. Figg, Jaishri O. Blakeley, Andrea M. Gross, Oxana Borisovna Kapustina, John Glod, Andrea Baldwin, Janet Therrien, Brigitte C. Widemann, Amanda Carbonell, Seth M. Steinberg, Eva Dombi, Staci Martin, Kara Heisey, D. Wade Clapp, Dominique C. Pichard, Brian Weiss, L. Austin Doyle, Scott M. Paul, Marie Claire Roderick, Amish C. Shah, David Venzon, Malcolm A. Smith, Miriam Bornhorst, Patricia Whitcomb, Ae Rang Kim, Pamela L. Wolters, Chi Zhang, Cody J. Peer, Michael Fisher
Publikováno v:
New England Journal of Medicine. 382:1430-1442
No approved therapies exist for inoperable plexiform neurofibromas in patients with neurofibromatosis type 1.We conducted an open-label, phase 2 trial of selumetinib to determine the objective response rate among patients with plexiform neurofibromas
Autor:
Paul L. Martin, Carl H. June, Henrique Bittencourt, Hidefumi Hiramatsu, G.D. Myers, Michael A. Pulsipher, Kapildeb Sen, Kara L. Davis, S. Rives, Michael R. Verneris, Yiyun Zhang, Gregory A. Yanik, David Lebwohl, Shannon L. Maude, Jochen Buechner, Christina Peters, Nicolas Boissel, Adriana Balduzzi, B. De Moerloose, Tanya Taran, Stephan A. Grupp, Krysta Schlis, Karen Thudium Mueller, Peter Bader, Michael Boyer, Mimi Leung, Muna Qayed, André Baruchel, Theodore W. Laetsch, Joerg Krueger, Bruce L. Levine, Patricia A. Wood, Heather E. Stefanski, Eneida R. Nemecek, Francoise Mechinaud
Publikováno v:
NEW ENGLAND JOURNAL OF MEDICINE
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
BACKGROUND: In a single-center phase 1-2a study, the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel produced high rates of complete remission and was associated with serious but mainly reversible toxic effects in children a
Publikováno v:
New England Journal of Medicine. 298:301-304
To assess the etiologic role of C. trachomatis and other micro-organisms in "idiopathic" epididymitis, 23 men underwent microbiologic studies, including cultures of epididymal aspirates in 16. Eleven of 13 men under the age of 35 years had C. trachom
Autor:
Deborah, Watson-Jones, Helen A, Weiss, Mary, Rusizoka, John, Changalucha, Kathy, Baisley, Kokugonza, Mugeye, Clare, Tanton, David, Ross, Dean, Everett, Tim, Clayton, Rebecca, Balira, Louise, Knight, Ian, Hambleton, Jerome, Le Goff, Laurent, Belec, Richard, Hayes, W, Kilama
Publikováno v:
New England Journal of Medicine. 358:1560-1571
Infection with herpes simplex virus type 2 (HSV-2) is associated with an increased risk of acquiring infection with the human immunodeficiency virus (HIV). This study tested the hypothesis that HSV-2 suppressive therapy reduces the risk of HIV acquis
Autor:
Rafat Abonour, Lawrence H. Einhorn, Stephen D. Williams, Susan M. Perkins, Amy Chamness, Mary J. Brames
Publikováno v:
New England Journal of Medicine. 357:340-348
BACKGROUND Metastatic testicular tumors that have not been successfully treated by means of initial chemotherapy are potentially curable with salvage chemotherapy. METHODS We conducted a retrospective review of 184 consecutive patients with metastati
Autor:
Jonathan G. Seidman, Barry J. Maron, Antonio R. Perez-Atayde, Gregory B. Wright, Walter H. Johnson, Ronald J. Kanter, Paolo Spirito, J. Philip Saul, Michael Arad, Joshua M. Gorham, Christine E. Seidman
Publikováno v:
New England Journal of Medicine. 352:362-372
background Unexplained left ventricular hypertrophy often prompts the diagnosis of hypertrophic cardiomyopathy, a sarcomere-protein gene disorder. Because mutations in the gene for AMP-activated protein kinase g 2 ( PRKAG2 ) cause an accumulation of