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Autor:
Minh M Nguyen, Junkui Ai, Tongying Shun, Gabriela Mustata Wilson, Peter Wipf, Sunita Shinde, Paul A. Johnston, Javid A. Dar, Daniel P. Camarco, Yun Hua, Joel B. Nelson, Zhou Wang, Khalid Z. Masoodi, John S. Lazo, Yujuan Wang, Donna M. Huryn
Publikováno v:
ASSAY and Drug Development Technologies. 14:226-239
Patients with castration-resistant prostate cancer (CRPC) can be treated with abiraterone, a potent inhibitor of androgen synthesis, or enzalutamide, a second-generation androgen receptor (AR) antagonist, both targeting AR signaling. However, most pa
Autor:
Taranalli Ashok Dundapa, Vijayasree V. Giridharan, Vasudevan Mani, Tetsuya Konishi, Kenichi Watanabe, Rajarajan Amirthalingam Thandavarayan
Publikováno v:
Journal of Medicinal Food. 14:912-919
Cognitive disorders such as dementia, attention deficits, and Alzheimer's disease (AD) have been well investigated. However, effective interventions for the promotion and progression of AD are unavailable to date. The present work was undertaken to i
Autor:
Stephen O. Oguntoye, Ayodele O. Soladoye, Adekemi J. Ibidapo, Sabitiu A. Oyeleke, Bamidele Victor Owoyele, Samuel O. Olaniran, Muhammed N. Negedu, S A Onasanwo, Joseph O. Sanya
Publikováno v:
Journal of Medicinal Food. 13:343-347
The analgesic and anti-inflammatory activities of Zea mays husk extract (25, 50, 100, and 200 mg/kg of body weight) were investigated in rats. The hot plate and formalin-induced paw licking models were used to assess analgesic effects of the extract,
Publikováno v:
Journal of Medicinal Food. 12:973-981
To reduce cardiovascular disease (CVD) by reducing circulating cholesterol concentrations, much attention has been focused on the search for dietary interventions for hypercholesterolemia. Corni Fructus is known to exhibit several biological activiti
Publikováno v:
Foodborne Pathogens and Disease. 5:21-31
Continuous flow cultures of feral (culture FC) and domesticated (culture RPCF) pig gut microflora were established in steady state. Cultures were continuously infused with 25 or 100 microg tylosin/mL and sampled at intervals to assess effects on tota
Autor:
Huiyuan Hou, Yusheng Wang, Xiu-Mei Yang, Chunxian Song, Jian-Feng Xu, Yuan-Yuan Shi, Peng Zhang, Yue Li
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 23:527-540
The aims of this study were to investigate the inhibitory efficacy of intravitreal dexamethasone acetate (DA)-loaded by (D, L-lactide-co-glycolide) (PLGA) nanoparticles on choroidal neovascularization (CNV) in a laser-induced rat model and to evaluat
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 20:489-508
DP-class prostaglandins and prostaglandin analogs (collectively, prostaglandins or PGs) such as PGD2, BW245C, ZK110841, and ZK118182, lower intraocular pressure (IOP) in animal models of ocular hypertension. A new analog of ZK118182 (AL-6556; 13,14-d
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 18:363-370
P2Y2 receptor agonists, like UTP and ATP, stimulate mucin secretion from goblet cells in vitro. Therefore, mucin stimulants could be good candidates for the treatment of dry eye syndrome because mucin increases the tear film stability and protects ag
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 5:99-110
The carbonic anhydrase (C.A.) inhibitor, L-650,719 (6-hydroxy-benzo[b]thiophene-2-sulfonamide) is an advance over the corresponding 6-OH benzothiazole-2-sulfonamide in increased water solubility (4 mM) and CHCl3/buffer partition (0.05). KI vs CA is 1