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Autor:
Vivien Pósa, Veronika F.S. Pape, Nikolett Jabronka, Éva A. Enyedy, Bianca Montsch, Lukas Uhlik, Sonja Hager, Bernhard K. Keppler, Szilárd Tóth, Christian R. Kowol, Petra Heffeter, Gergely Szakács
Publikováno v:
Antioxidants & Redox Signaling. 33:395-414
Aims: Due to their significant biological activity, thiosemicarbazones (TSCs) are promising candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to chelate essential metal ions such as copper and iron. Triapine,
Autor:
Alexander S. Keller, Brant E. Isakson
Publikováno v:
Antioxidants & Redox Signaling. 26:881-885
Heterocellular communication between different cell types of the vasculature, both within the blood vessel wall and cells interacting with the blood vessel wall, is absolutely vital and must be tightly regulated. In this Forum, the role of four diffe
Autor:
Vera Adam-Vizi
Publikováno v:
Antioxidants & Redox Signaling. 7:1140-1149
Overwhelming evidence has accumulated indicating that oxidative stress is a crucial factor in the pathogenesis of neurodegenerative diseases. The major site of production of superoxide, the primary reactive oxygen species (ROS), is considered to be t
Publikováno v:
Antioxidants & Redox Signaling. 2:779-787
A growing body of evidence has suggested that a membrane-bound NADH/NADPH oxidase is the predominant source of reactive oxygen species (ROS) in vascular cells. Prior studies have used indirect assessments of superoxide including lucigenin-enhanced ch
Publikováno v:
Antioxidants & Redox Signaling. 2:47-54
Reactive oxygen species (ROS) are often shown to damage cellular functions. The targets of oxidative damage depend on the nature of ROS produced and the site of generation. In contrast, ROS can also regulate signal transduction. In this case, ROS may