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Publikováno v:
Antioxidants & Redox Signaling
Significance: Magnetic resonance imaging (MRI) with hyperpolarized (HP) 13C-labeled redox-sensitive metabolic tracers can provide noninvasive functional imaging biomarkers, reflecting tissue redox state, oxidative stress, and inflammation, among othe
Autor:
Angela Fago, Birgitte Geert Jensen
Publikováno v:
Jensen, B & Fago, A 2020, ' A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood ', Antioxidants & Redox Signaling, vol. 32, no. 4, pp. 258-265 . https://doi.org/10.1089/ars.2019.7877
Significance: Along with other gasotransmitters nitric oxide (NO) and carbon monoxide, hydrogen sulfide (H2S) has recently emerged as an important signaling molecule with a particularly complex metabolism. Endogenous H2S reacts with multiple cellular
Autor:
Hideo Kimura
Publikováno v:
Antioxidants & Redox Signaling. 27:619-621
Hydrogen sulfide (H2S) has been demonstrated to have physiological roles such as neuromodulation, vascular tone regulation, cytoprotection, oxygen sensing, inflammatory regulation, and cell growth. Recently, hydrogen polysulfides (H2Sn) have been fou
Autor:
Andrea Olschewski, Edward Kenneth Weir
Publikováno v:
Antioxidants & Redox Signaling
Significance: The pulmonary circulation is a low-pressure, low-resistance, highly compliant vasculature. In contrast to the systemic circulation, it is not primarily regulated by a central nervous control mechanism. The regulation of resting membrane
Publikováno v:
Antioxidants & Redox Signaling. 19:36-45
Human protein disulfide isomerase (hPDI) is a key enzyme and a redox-regulated chaperone responsible for oxidative protein folding in the endoplasmic reticulum. This work aims to reveal the molecular mechanism underlying the redox-regulated functions
Autor:
Paul W. Buehler, Abdu I. Alayash
Publikováno v:
Antioxidants & Redox Signaling. 6:1000-1010
Oxygen (O(2)) sensing in blood and regulation of microvascular tone appear to involve hemoglobin (Hb) conformational changes resulting from O(2) desaturation. This observation has prompted the thought that Hb functions as both an O(2) sensor and regu
Autor:
Katrin Linke, Ursula Jakob
Publikováno v:
Antioxidants & Redox Signaling. 5:425-434
Cellular compartments differ dramatically in their redox potentials. This translates directly into variations in the extent of disulfide bond formation within proteins, depending on their cellular localization. It has long been assumed that proteins
Publikováno v:
Antioxidants & Redox Signaling. 3:189-202
Three distinct antioxidant pathways are considered through which iron-catalyzed oxidative stress may be regulated by nitric oxide (NO). The first two pathways involve direct redox interactions of NO with iron catalytic sites and represent a fast resp
Publikováno v:
Antioxidants & Redox Signaling. 2:739-752
Heme-hemopexin (2-10 microM) is used as a model for intravenous heme released in trauma, stroke, and ischemia-reperfusion. A transient increase in cellular protein oxidation occurs during receptor-mediated heme transport from hemopexin which is inhib
Autor:
Grigory G. Borisenko, Yulia Y. Tyurina, John S. Lazo, Valerian E. Kagan, Linda L. Pearce, Jamal A. Razzack, Bruce R. Pitt, James P. Fabisiak, Vladimir A. Tyurin
Publikováno v:
Antioxidants & Redox Signaling. 1:349-364
Metallothioneins (MTs) are cysteine-rich metal-binding proteins that exert cytoprotection during metal exposure and oxidative stress. The roles of MT in copper (Cu) binding and release and modulation of redox cycling are unresolved. We hypothesized t