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Autor:
Brian Deng, Natalia Kyui, Júlio S. Rebouças, Margaret E. Tome, Artak Tovmasyan, Ting-Ting Huang, Melba C. Jaramillo, Romulo S. Sampaio, Jacqueline C. Bueno-Janice, Ivan Spasojevic, Ines Batinic-Haberle, Ludmil Benov
Publikováno v:
Antioxidants & Redox Signaling. 29:1196-1214
Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H(2)O(2) and utilizing it subsequently in protein S-glutathionylation
Publikováno v:
Antioxidants & Redox Signaling. 21:755-767
Significance: The therapeutic effects of current micellar and vesicular drug formulations are restricted by slow and inefficient drug release at the pathological site. The development of smart polymeric nanocarriers that release drugs upon arriving a
Publikováno v:
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
Cell proliferation, a main target in cancer therapy, is influenced by the surrounding three-dimensional (3D) extracellular matrix (ECM). In vitro drug screening is, thus, optimally performed under conditions in which cells are grown (embedded or trap
Autor:
María C. López-Martínez, Francisco J. Nicolás, Francisco J Rodríguez Lozano, Luis Meseguer Olmo, Miguel Blanquer, José M Moraleda Jiménez, Xavier Férez Ruiz, Consuelo Funes, Carmen L. Insausti, Valentín Cabañas Perianes, Maria Juliana Majado
Publikováno v:
Stem Cells and Development. 21:260-272
The density gradient centrifugation method was originally designed for the isolation of mononuclear peripheral blood cells and rapidly adapted to fractionate bone marrow (BM) cells. This method involves the use of gradient density solutions with low
Publikováno v:
Tissue Engineering Part A. 17:2965-2971
In vivo, endothelial cells grow on the inner surface of blood vessels and are shaped to conform to the vessel's geometry. In the smallest vessels this shape entails substantial bending within each cell. Microfabricated channels can replicate these sm
Publikováno v:
DNA and Cell Biology. 26:160-171
Nanosecond pulsed electric fields (nsPEFs) are a type of nonthermal, nonionizing radiation that exhibit intense electric fields with high power, but low energy. NsPEFs extend conventional electroporation (EP) to affect intracellular structures and fu