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Autor:
Vivien Pósa, Veronika F.S. Pape, Nikolett Jabronka, Éva A. Enyedy, Bianca Montsch, Lukas Uhlik, Sonja Hager, Bernhard K. Keppler, Szilárd Tóth, Christian R. Kowol, Petra Heffeter, Gergely Szakács
Publikováno v:
Antioxidants & Redox Signaling. 33:395-414
Aims: Due to their significant biological activity, thiosemicarbazones (TSCs) are promising candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to chelate essential metal ions such as copper and iron. Triapine,
Publikováno v:
Antioxidants & Redox Signaling. 19:1846-1854
Significance: Regulation of the activity of the chloroplast ATP synthase is largely accomplished by the chloroplast thioredoxin system, the main redox regulation system in chloroplasts, which is directly coupled to the photosynthetic reaction. We rev
Publikováno v:
Antioxidants & Redox Signaling. 19:36-45
Human protein disulfide isomerase (hPDI) is a key enzyme and a redox-regulated chaperone responsible for oxidative protein folding in the endoplasmic reticulum. This work aims to reveal the molecular mechanism underlying the redox-regulated functions
Autor:
Allen Chen, Shaul Reuveny, Jian Li, Steve Oh, Boon Chin Heng, Simon M. Cool, William R. Birch
Publikováno v:
Stem Cells and Development. 21:1701-1715
While defining the environment for human embryonic stem cell (hESC) culture on 2-dimensional (2D) surfaces has made rapid progress, the industrial-scale implementation of this technology will benefit from translating this knowledge into a 3-dimension
Publikováno v:
Antioxidants & Redox Signaling
Stable major histocompatibility complex (MHC) class I molecules at the cell surface consist of three separate, noncovalently associated components: the class I heavy chain, the β2-microglobulin light chain, and a presented peptide. These three compo
Publikováno v:
Antioxidants & Redox Signaling. 15:393-404
Historically, hydrogen sulfide (H2S) has been regarded as a poisonous gas, with a wide spectrum of toxic effects. However, like ·NO and CO, H2S is now referred to as a signaling gas involved in numerous physiological processes. The list of reports h
Autor:
Kostas Tokatlidis, Dionisia P. Sideris
Publikováno v:
Antioxidants & Redox Signaling. 13:1189-1204
Disulfide bond formation is a crucial step for oxidative folding and necessary for the acquisition of a protein's native conformation. Introduction of disulfide bonds is catalyzed in specialized subcellular compartments and requires the coordinated a
Autor:
Patricia Rico, George Altankov, Manuel Salmerón-Sánchez, David Moratal, José Carlos Rodríguez Hernández, M. Monleón Pradas
Publikováno v:
Tissue Engineering Part A. 15:3271-3281
The influence of surface chemistry-substrates with controlled surface density of -OH groups-on fibronectin (FN) conformation and distribution is directly observed by atomic force microscopy (AFM). FN fibrillogenesis, which is known to be a process tr
Publikováno v:
Antioxidants & Redox Signaling. 9:1097-1110
We previously constructed computational models based on the biochemical pathway analysis of different nitric oxide (NO) synthase isoforms and found a large discrepancy between our predictions and perivascular NO measurements, suggesting the existence
Publikováno v:
DNA and Cell Biology. 24:283-291
Nanosecond pulsed electric fields (nsPEFs) are ultrashort pulses with high electric field intensity (kV/cm) and high power (megawatts), but low energy density (mJ/cc). To determine roles for p53 in response to nsPEFs, HCT116 cells (p53+/+ and p53-/-)