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Autor:
Guillaume Allée, Isabelle Paty, Stefanie Dimmeler, Andreas M. Zeiher, Helene Darville, Willy Gosgnach, Ariane Fischer, Wesley Abplanalp, Rusty Montgomery, Linda Pestano, Francoise Fougerousse, David John
Publikováno v:
Nucleic Acid Therapeutics. 30:335-345
MicroRNA (miRNA) inhibition is a promising therapeutic strategy in several disease indications. MRG-110 is a locked nucleic acid-based antisense oligonucleotide that targets miR-92a-3p and experimentally was shown to have documented therapeutic effec
Autor:
Shantharam Joshi, Janina Baranowska-Kortylewicz, John G Sharp, Timothy R. McGuire, Don W. Coulter
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 35:418-424
Osteosarcoma (OST) is the most common bone tumor in children and adolescents with a second peak of incidence in elderly adults usually diagnosed as secondary tumors in Paget's disease or irradiated bone. Subjects with metastatic disease or whose dise
Autor:
Shenglin Huang, Haixia Guan, Xiao Shi, Yu-Long Wang, Jia-Qian Hu, Ning Qu, Ting-Ting Zhang, Qinghai Ji, Yu Wang, Wei-Yan Liu, Jingjing Zhao, Tian Liao, Shishuai Wen, Rong-Liang Shi
Publikováno v:
Thyroid. 30:1025-1036
Background: Sporadic medullary thyroid carcinoma (MTC) is a relatively uncommon neuroendocrine malignancy and the molecular tumorigenesis of its sporadic type (sMTC) is only partially understood. In this study, we performed a study focusing on the ge
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 35:371-376
Background: It has been reported that long noncoding RNA (lncRNA) MT1JP played a tumor-suppressive role in the development of many organs, such as liver and lung, but the exact mechanism is still u...
Autor:
Qinghai Ji, Yu-Long Wang, Cui-Wei Li, Wen-Jun Wei, Ben Ma, Rong-Liang Shi, Peng-Cheng Yu, Li-Cheng Tan, Bo-Wen Lei, Jia-Qian Hu, Yu Wang, Nai-Si Huang, Yan Zhang, Weibo Xu, Xiao Shi, Tong-Zhen Chen, Xiao Wang, Jie Wang
Publikováno v:
Thyroid. 29:1269-1278
Background: Expression of the programmed death-ligand 1 (PD-L1) in medullary thyroid carcinoma (MTC) has been rarely reported. In this study, we evaluated PD-L1 positivity in MTC and analyzed its c...
Autor:
Lucy Phillips, Shiguang Liu, Fang Wang, Li Yang, Oxana Ibraghimov-Beskrovnaya, Deidre Mackenna, Jifan Guo, Suxia Wang, Wenping Song, Jie Ding, Ekkehard Leberer, Cynthia Pryce, Ethan Y Xu, Qun He, Yanqin Zhang, Joseph Boulanger
Publikováno v:
Human Gene Therapy. 30:865-881
Alport syndrome is a genetic disease caused by mutations in type IV collagen and is characterized by progressive kidney disease. The Col4α3−/− mouse model recapitulates the main features of human A...
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37:239-244
Breast cancer (BC) is a multistep disease that is thought to result from an interaction between genetic background and environmental factors. In Iran, one of the strongest risk factors for developing BC is a positive family history of the disease. Re
Autor:
Wei-Shan Hung, Hui-Ju Tsai, Ching-Ping Tseng, Hsing-Ying Lee, Yu-Ting Chen, Jen-Der Lin, Kong-Kit Leong, Hsueh-Ling Hsu, Ying-Ru Wang, Miaw-Jene Liou
Publikováno v:
Thyroid. 28:1479-1489
Thyroid cancer is the most common endocrine tumor and generally has relatively good clinical outcomes. However, 15-20% of patients ultimately develop recurrence or disease-related death. The appropriate prognostic factors for thyroid cancer are still
Autor:
Olga Leplina, Marina A. Tikhonova, Sergey Chernov, S. V. Mishinov, E. V. Dolgova, T. V. Tyrinova, Alexander A. Ostanin, Elena R. Chernykh, Evgeniya Voronina, Anton Kalinovskiy, Ekaterina Ya. Shevela, V. V. Stupak, Sergey S. Bogachev
Publikováno v:
Journal of Interferon & Cytokine Research. 38:298-310
Besides initiation of tumor-specific T cell immunity, dendritic cells (DCs) are endowed with tumoricidal activity. Previously, we showed that monocyte-derived DCs of high-grade glioma patients generated in the presence of interferon alpha (IFNα) (IF
Autor:
Pearlly S. Yan, Ralf Bundschuh, Huiling He, Pamela Brock, Jackson A. Killian, Rulong Shen, W. G. Li, Albert de la Chapelle, Nyla A. Heerema, Jadwiga Labanowska
Publikováno v:
Thyroid. 28:748-754
Background: The BRAF(V600E) mutation is the most common driver in papillary thyroid carcinoma (PTC) tumors. In recent years, gene fusions have also been recognized as important drivers of cancer in PTC. Previous studies have suggested that thyroid tu