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Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes
Autor:
Christoph Rademacher, Sven Hennig, David Bier, Gernot Hahne, Tom N. Grossmann, Tanja Bange, Jonas Hanske, Chang-Uk Lee
Publikováno v:
Angewandte Chemie International Edition in English, 54(46), 13796-13800. John Wiley and Sons Ltd
Angewandte Chemie (International Ed. in English)
Lee, C-U, Hahne, G, Hanske, J, Bange, T, Bier, D, Rademacher, C, Hennig, S & Grossmann, T N 2015, ' Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes ', Angewandte Chemie International Edition in English, vol. 54, no. 46, pp. 13796-13800 . https://doi.org/10.1002/anie.201506338
Angewandte Chemie (International Ed. in English)
Lee, C-U, Hahne, G, Hanske, J, Bange, T, Bier, D, Rademacher, C, Hennig, S & Grossmann, T N 2015, ' Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes ', Angewandte Chemie International Edition in English, vol. 54, no. 46, pp. 13796-13800 . https://doi.org/10.1002/anie.201506338
PTEN is a dual-specificity protein tyrosine phosphatase. As one of the central tumor suppressors, a thorough regulation of its activity is essential for proper cellular homeostasis. The precise implications of PTEN inhibition by reactive oxygen speci