Zobrazeno 1 - 2
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pro vyhledávání: '"Cope, Andrew P"'
Autor:
Purvis, Harriet A, Clarke, Fiona, Jordan, Christine K, Blanco, Cristina Sanchez, Cornish, Georgina H, Dai, Xuezhi, Rawlings, David J, Zamoyska, Rose, Cope, Andrew P
Publikováno v:
European Journal of Immunology
Purvis, H A, Clarke, F, Jordan, C K, Blanco, C S, Cornish, G H, Dai, X, Rawlings, D J, Zamoyska, R & Cope, A P 2018, ' Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice ', European Journal of Immunology, vol. 48, no. 2, pp. 306-315 . https://doi.org/10.1002/eji.201747092
Purvis, H A, Clarke, F, Jordan, C K, Blanco, C S, Cornish, G H, Dai, X, Rawlings, D J, Zamoyska, R & Cope, A P 2018, ' Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice ', European Journal of Immunology, vol. 48, no. 2, pp. 306-315 . https://doi.org/10.1002/eji.201747092
A single nucleotide polymorphism within the PTPN22 gene is a strong genetic risk factor predisposing to the development of multiple autoimmune diseases. PTPN22 regulates Syk and Src family kinases downstream of immuno-receptors. Fungal β-glucan rece
Autor:
Fraser, Louise D., Zhao, Yuan, Lutalo, Pamela M K, D’Cruz, David, Cason, John, Silva O'Hare, Joselli, Dunn-Walters, Deborah, Nayar, Saba, Cope, Andrew P., Spencer, Jo
Publikováno v:
European Journal of Immunology
Fraser, L D, Zhao, Y, Lutalo, P M K, D’Cruz, D, Cason, J, Silva O'Hare, J, Dunn-Walters, D, Nayar, S, Cope, A P & Spencer, J 2015, ' Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus ', European Journal of Immunology, vol. 45, no. 8, pp. 2409-2419 . https://doi.org/10.1002/eji.201545599
Fraser, L D, Zhao, Y, Lutalo, P M K, D’Cruz, D, Cason, J, Silva O'Hare, J, Dunn-Walters, D, Nayar, S, Cope, A P & Spencer, J 2015, ' Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus ', European Journal of Immunology, vol. 45, no. 8, pp. 2409-2419 . https://doi.org/10.1002/eji.201545599
The principles of allelic exclusion state that each B cell expresses a single light and heavy chain pair. Here, we show that B cells with both kappa and lambda light chains (Igκ and Igλ) are enriched in some patients with the systemic autoimmune di