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Autor:
Yingzi Zhao, Fang Zong
Publikováno v:
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1439-1446 (2021)
Immunity, Inflammation and Disease, Vol 9, Iss 4, Pp 1439-1446 (2021)
Background Pre‐eclampsia (PE) is mainly attributed to the inflammation of trophoblast cells in pregnant women, which results in damage to the maternal organs and growth retardation of the fetus. Alkaloid leonurine (LNR) is a plant compound and has
Autor:
Cayman Williams, Alan Kennedy, Shane Minogue, Neil Halliday, Erin Waters, David M. Sansom, Tie Zheng Hou, Behzad Rowshanravan, Daniel Janman, Claudia Hinze, Omar S. Qureshi
Publikováno v:
Immunology
CTLA‐4 is an essential regulator of T‐cell immune responses whose intracellular trafficking is a hallmark of its expression. Defects in CTLA‐4 trafficking due to LRBA deficiency cause profound autoimmunity in humans. CTLA‐4 rapidly internaliz
Publikováno v:
Immunology
Summary We have previously identified that human Ku70, a nuclear protein, serves as a cytosolic DNA sensor. Upon transfection with DNA or infection with DNA virus, Ku70 translocates from the nucleus into the cytoplasm and then predominately induces i
Autor:
Yanjie Peng, Lin Zhang, Xietong Wang, Meihua Zhang, Shuxian Li, Anna Li, Junxia Li, Zhenya Fang
Publikováno v:
Journal of Cellular and Molecular Medicine
Chorioamnionitis (CAM), as a common intrauterine infectious disease, is the leading cause of premature birth, stillbirth, neonatal infection and sepsis. The formyl peptide receptor 2 (FPR2) is a member of GPCRs widely distributed in a variety of tiss
Publikováno v:
Immunity, Inflammation and Disease
Immunity, Inflammation and Disease, Vol 8, Iss 4, Pp 568-583 (2020)
Immunity, Inflammation and Disease, Vol 8, Iss 4, Pp 568-583 (2020)
Iron is known not only for its importance in cellular and metabolic pathways but also for its role in causing cellular toxicities such as production of reactive oxygen species and growth of pathogens. The inability of the human body to physiologicall
Autor:
Irene Soria, Mario Pérez-Diego, José Luis Subiza, Oscar Palomares, Cristina Benito-Villalvilla, Enrique Fernández-Caldas
Publikováno v:
Allergy
Background Polymerized allergoids conjugated to mannan (PM) are suitable vaccines for allergen‐specific immunotherapy (AIT). Alum remains the most widely used adjuvant in AIT, but its way of action is not completely elucidated. The better understan
Publikováno v:
Immunology
The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568a1598da3fbd8ece6a516ec9a25a0f
https://europepmc.org/articles/PMC8517588/
https://europepmc.org/articles/PMC8517588/
Autor:
Trisha Mahtani, Bebhinn Treanor
Publikováno v:
Immunological Reviews
Although calcium signaling and the important role of calcium release–activated calcium channels is well recognized in the context of immune cell signaling, there is a vast diversity of ion channels and transporters that regulate the entry of ions b
Autor:
Michael M. Awad, Carlos A. Puyo, Alexander Earhart, Marin H. Kollef, Nicholas Staten, Colleen Haug, Oliver A. Prince
Publikováno v:
Journal of Leukocyte Biology
Tracheitis secondary to placement of an endotracheal tube (ETT) is characterized by neutrophil accumulation in the tracheal lumen, which is generally associated with epithelial damage. Mitochondrial DNA (mtDNA), has been implicated in systemic inflam
Publikováno v:
Clinical and Experimental Immunology
Summary Autoantibodies characteristic for anti-phospholipid syndrome (APS) and systemic lupus erythematosus (SLE) are anti-β2-glycoprotein I (β2GPI) antibodies and anti-DNA antibodies, respectively, and almost half of APS cases occur in SLE. Anti-