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Publikováno v:
Journal of Cellular and Molecular Medicine
CDR1as is a well‐identified circular RNA with regulatory roles in a variety of physiological processes. However, the effects of CDR1as on stemness of periodontal ligament stem cells (PDLSCs) and the underlying mechanisms remain unclear. In this stu
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine
Biomaterial‐based therapy that can restore annulus fibrosus (AF) function in early stage and promote endogenous repair of AF tissues is a promising approach for AF tissue repair. In this study, we established a genipin‐crosslinked decellularized
PFN1 and integrin‐β1/mTOR axis involvement in cornea differentiation of fibroblast limbal stem cells
Autor:
Carla Giordano, Valentina Failla, Salvatore Cillino, Laura Tomasello, Antonina Coppola, Giuseppe Pizzolanti, Maria Pitrone
Publikováno v:
Journal of Cellular and Molecular Medicine
Ex vivo limbal stem cell transplantation is the main therapeutic approach to address a complete and functional re‐epithelialization in corneal blindness, the second most common eye disorder. Although important key points were defined, the molecular
Autor:
Jiayi Zhang, Mingdeng Rong, Chuying Chen, Zhihui Tian, Zijie Wang, Tengfei Zhou, Hongxing Chu
Publikováno v:
Cell Proliferation
Objectives Conditioned medium (CM) from 2D cell culture can mitigate the weakened regenerative capacity of the implanted stem cells. However, the capacity of 3D CM to prime dental pulp stem cells (DPSCs) for pulp regeneration and its protein profile
Autor:
Xuemei Liu, Meiling Wu, Bei Li, Hao Guo, Kun Xuan, Zihan Li, Xiaoxue Yang, Yan Jin, Xiaoyao Huang, Xiaohe Guo
Publikováno v:
Cell Proliferation
Objectives Pulp regeneration brings big challenges for clinicians, and vascularization is considered as its determining factor. We previously accomplished pulp regeneration with autologous stem cells from deciduous teeth (SHED) aggregates implantatio
Autor:
Long Wang, Chao Li, Yong Chen, Xiaoling Guo, Shenzhi Zhao, Weiping Ji, Xianwu Chen, Zhangye Xu, Ren-Shan Ge
Publikováno v:
Journal of Cellular and Molecular Medicine
Leydig cells (LCs) are the primary source of testosterone in the testis, and testosterone deficiency caused by LC functional degeneration can lead to male reproductive dysfunction. LC replacement transplantation is a very promising approach for this
Autor:
Emilie Chapuis, Carole Lambert, Hanane Chajra, Daniel Auriol, Patrick Robe, Amandine Scandolera, Cyrille Jarrin, Romain Reynaud, Marie Meunier
Publikováno v:
Journal of Cosmetic Dermatology
Background Healthy skin is a delicate balance between skin renewal and microbiota homeostasis, and its imbalance promotes premature aging and dermatological disorders. Skin stem cells are key actors in this process but their sensitivity to aging and
Publikováno v:
Advanced Science
Advanced Science, Vol 8, Iss 7, Pp n/a-n/a (2021)
Advanced Science, Vol 8, Iss 7, Pp n/a-n/a (2021)
The application of induced pluripotent stem cells (iPSCs) in disease modeling and regenerative medicine can be limited by the prolonged times required for functional human neuronal differentiation and traditional 2D culture techniques. Here, a conduc
Publikováno v:
Cell Proliferation
Objectives Stromal cell‐derived factor‐1 (SDF‐1) actively directs endogenous cell homing. Exendin‐4 (EX‐4) promotes stem cell osteogenic differentiation. Studies revealed that EX‐4 strengthened SDF‐1‐mediated stem cell migration. Howe
Publikováno v:
Stem Cells Translational Medicine
Summary Kidney-derived c-Kit+ cells exhibit progenitor/stem cell properties in vitro (self-renewal capacity, clonogenicity, and multipotentiality). These cells can regenerate epithelial tubular cells following ischemia-reperfusion injury and accelera