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Publikováno v:
Journal of Cellular and Molecular Medicine
Extracellular cold‐inducible RNA‐binding protein (CIRP) is a proinflammatory mediator that aggravates ischaemia‐reperfusion injury (IRI). Normothermic machine perfusion (NMP) could effectively alleviate the IRI of the liver, but the underlying
Publikováno v:
Journal of Cellular and Molecular Medicine
Karyopherin α2 (KPNA2), involved in nucleocytoplasmic transport, has been reported to be up‐regulated in tumorigenesis. However, comprehensive studies of KPNA2 functions in renal cell carcinoma (RCC) are still lacking. In this study, we aim to inv
Autor:
Wenhao Hu, Teng Li, Xuesong Zhang, Fanqi Hu, Quanbo Ji, Deng-bin Qi, Xiaoqing Yang, Weibo Liu, Qi Wang, Hui Chen
Publikováno v:
Journal of Cellular and Molecular Medicine
Osteosarcoma (OS) is a sarcoma with high rates of pulmonary metastases and mortality. The mechanisms underlying tumour generation and development in OS are not well‐understood. Haematopoietic cell kinase (HCK), a vital member of the Src family of k
Publikováno v:
Journal of Cellular and Molecular Medicine
The tumour‐suppressive role of LINC00472 has been extensively reported in various human cancers such as lung, colon and ovarian cancers, yet its function in pancreatic cancer remains unidentified. Here, the current research aimed to explore the rol
Autor:
Ying Yan, Wenju Chen, Yueyin Pan, Jiayu Niu, Hui-qin Luo, Shusheng Wu, Yifu He, Huimin Li, Huijun Xu, Lulu Cao, Xiaoxiu Hu, Lihong Ke
Publikováno v:
Journal of Cellular and Molecular Medicine
Previous studies have indicated that centromere protein K (CENPK) is upregulated in several cancers and related to tumorigenesis. Nevertheless, the potential function of CENPK in gastric cancer (GC) remains unknown. Here, we investigated the function
Autor:
Chih-Chao Yang, John Y. Chiang, Yi-Chen Li, Pei-Hsun Sung, Hon-Kan Yip, Mel S. Lee, Kuan-Hung Chen, Tien-Hung Huang
Publikováno v:
Journal of Cellular and Molecular Medicine
This study tested the hypothesis that therapy with double overexpression of miR‐19a‐3p and miR‐20a‐5p (miRDOE) to human inducible pluripotent stem cell–derived mesenchymal stem cells (iPS‐MSCs) was superior to iPS‐MSCs alone for preserv
Publikováno v:
Journal of Cellular and Molecular Medicine
Smoking and Candida albicans (C. albicans) infection are risk factors for many oral diseases. Several studies have reported a close relationship between smoking and the occurrence of C. albicans infection. However, the exact underlying mechanism of t
Publikováno v:
Journal of Cellular and Molecular Medicine
Sestrin2 (SESN2) is a conserved stress‐inducible protein (also known as hypoxia‐inducible gene 95 (HI95)) that is induced under hypoxic conditions. SESN2 represses the production of reactive oxygen species (ROS) and provides cytoprotection agains
Publikováno v:
Journal of Cellular and Molecular Medicine
Prostate cancer is a major health concern in males worldwide, owing to its high incidence. Sparstolonin B (SsnB), a component of the Chinese herbal medicine Sparganium stoloniferum, is used to treat many diseases. However, the effects and mechanisms
Publikováno v:
Journal of Cellular and Molecular Medicine
To efficiently prevent diabetic cardiomyopathy (DCM), we have explored and confirmed that metallothionein (MT) prevents DCM by attenuating oxidative stress, and increasing expression of proteins associated with glucose metabolism. To determine whethe