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Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 24, Pp 8934-8943 (2021)
Cancer Medicine, Vol 10, Iss 24, Pp 8934-8943 (2021)
Background Many real‐world studies of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) are restricted to single centers, limiting the generalizability of their insights. This study aimed to identify important population‐based pre
Autor:
Eiji Shinozaki, Hiroki Osumi, Mariko Ogura, Keisho Chin, Kensei Yamaguchi, Izuma Nakayama, Daisaku Kamiimabeppu, Takeru Wakatsuki, Keitaro Shimozaki, Daisuke Takahari, Akira Ooki
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 24, Pp 8820-8828 (2021)
Cancer Medicine, Vol 10, Iss 24, Pp 8820-8828 (2021)
Background Circulating tumor DNA (ctDNA) is a biomarker with potential to reflect comprehensive genomic information and overcome intratumor heterogeneity. In contrast, carcinoembryonic antigen (CEA) is a conventional tumor marker for predicting recur
Publikováno v:
Journal of Cellular and Molecular Medicine
The cell division cycle associated 8 (CDCA8) is a crucial component of the chromosome passenger complex (CPC). It has been implicated in the regulation of cell dynamic localization during mitosis. However, its role in hepatocellular carcinoma (HCC) i
Autor:
Noriyuki Yamada, Noriyuki Uesugi, Mai Hashimoto, Takayuki Matsumoto, Mitsumasa Osakabe, Makoto Eizuka, Yoshihito Tanaka, Ryo Sugimoto, Tamotsu Sugai, Naoki Yanagawa
Publikováno v:
Histopathology
AIMS Recent studies have shown that the microenvironment can include cancer cells and cancer-associated fibroblasts (CAFs), and that both play important roles in the progression and metastasis of CRC. Here, we aimed to analyse the expression patterns
Autor:
Zhihai Liang, Er-Dan Wei, Li-Ye Zhu, Shi-Quan Liu, Lan Lin, Shibo Luo, Jie-An Huang, Jiangni Wu, Xinze Qiu, Mengbin Qin, Da Chen, Zhenhua Fu
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 17, Pp 6010-6021 (2021)
Cancer Medicine, Vol 10, Iss 17, Pp 6010-6021 (2021)
Invasion and metastasis are the main causes of colorectal cancer (CRC)‐related death. Accumulating evidence suggested that sphingosine kinase 1 (SphK1) promoted the metastasis of CRC and autophagy played an important role in SphK1 promoting the met
Autor:
Seung Joon Kim, Mi Hyun Kim, Cheol-Kyu Park, Kye Young Lee, Shin Yup Lee, Jeong Seon Ryu, Sang Hoon Lee, Seung Hun Jang, Seong Hoon Yoon, Taeyun Kim, Sei Hoon Yang, Jeong Eun Lee, Yoon Soo Chang, Chan Kwon Park, Sung Yong Lee, Tae-Won Jang, Chang-Min Choi
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 17, Pp 5809-5822 (2021)
Cancer Medicine, Vol 10, Iss 17, Pp 5809-5822 (2021)
Objectives The optimal sequence for the administration of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) for treating non‐small cell lung cancer (NSCLC) is still unclear. This study aimed to evaluate the efficacy of seque
Autor:
Xiaoying Sun, Duanfeng Jiang, Guozhen Zhang, Xiaotao Wang, Qiuyu Mo, Fangping Chen, Qiangqiang Zhao, Min Dong
Publikováno v:
Cancer Science
Diffuse large B cell lymphoma (DLBCL) heterogeneity promotes recurrence and anti‐CD20‐based therapeutic resistance. Previous studies have shown that downregulation of MS4A1/CD20 expression after chemoimmunotherapy with rituximab leads to rituxima
Autor:
Menglu Zhang, Meng Zhou, Changchang Wang, Xiang Wang, Jie Wang, Hongxia Gao, Hengqiang Zhao, Zeyu Xing, Tianyi Qian, Hongyan Chen, Jiaqi Liu, Siqi Bao, Xiangzhi Meng, Xin Wang, Yalun Li
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 9, Pp 2466-2479 (2021)
Molecular Oncology, Vol 15, Iss 9, Pp 2466-2479 (2021)
Sentinel lymph node (LN) biopsy is currently the standard procedure for clinical LN‐negative breast cancer (BC) patients but it is prone to false‐negative results and complications. Thus, an accurate noninvasive approach for LN staging is urgentl
Autor:
Yusuke Ono, Ryohei Katayama, Noriko Yanagitani, Ken Uchibori, Makoto Nishio, Satoru Kitazono, Ryo Ariyasu, Ryohei Yoshida, Yusuke Mizukami, Mika Tsukahara, Takaaki Sasaki, Kazuma Kiyotani, Yuichi Ishikawa, Naoya Fujita, Hironori Ninomiya
Publikováno v:
Cancer Science
Osimertinib is a third‐generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR‐TKI) that is effective in treating both naïve and T790M‐mutated EGFR‐TKI‐resistant non–small cell lung cancer patients. The EGFR C797S mut
Autor:
Manjunath Nookala, Vikram Gota, Ashwin Karanam, Anand P. Patil, Navin Goyal, Ashish Singh, Murari Gurjar, Avinash Bonda, Yogesh Kembhavi, Sudeep Gupta, Bharati Shriyan
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 9, Pp 3068-3076 (2021)
Cancer Medicine, Vol 10, Iss 9, Pp 3068-3076 (2021)
Background Paclitaxel is dosed according to body surface area (BSA) but there is scant information on actual drug exposure in overweight and obese patients. Methods Early breast cancer patients receiving paclitaxel at 175 mg/m2 every 3 weeks, in two